60509-35-5

Usage

Uses

Used in Pharmaceutical Industry:
N-(4-Fluorobenzyl)butan-1-amine is used as a building block for the synthesis of various pharmaceuticals. Its fluorine atom and benzyl group make it a versatile compound for drug design, enhancing the biological activity and metabolic stability of pharmaceutical compounds.
Used in Agrochemical Industry:
N-(4-Fluorobenzyl)butan-1-amine is also used as a precursor in the synthesis of various agrochemicals. Its unique structure allows for the development of new and effective compounds for agricultural applications.
Used in Organic Synthesis:
N-(4-Fluorobenzyl)butan-1-amine is used as a building block in organic synthesis, enabling the creation of a wide range of organic molecules for various applications. Its versatility and unique structure make it a valuable compound in the field of organic chemistry.

InChI:InChI=1/C11H16FN/c1-2-3-8-13-9-10-4-6-11(12)7-5-10/h4-7,13H,2-3,8-9H2,1H3

Upstream product

• 459-23-4 4-fluorobenzaldoxime 
• 123-72-8 butyraldehyde 
• 109-65-9 1-bromo-butane 
• 140-75-0 para-fluorobenzylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 108088-69-3 4-fluorobenzylidenebutylamine 
• 109-73-9 N-butylamine 

Relevant academic research and scientific papers

Photocatalyzed cascade Meerwein addition/cyclization of: N -benzylacrylamides toward azaspirocycles

A visible-light-induced cascade Meerwein addition/cyclization of alkenes involving C-F bond cleavage was developed. This method offers a rapid access to azaspirocyclic cyclohexadienones from N-benzylacrylamides via C-F bond cleavage applying H2O as an external oxygen source, allowing for the incorporation of various aromatic moieties originating from aryldiazonium salts.

Comparative evaluation of trace heavy metal ions in water sample using complexes of dithioligands by flame atomic absorption spectrometry

Four new complexes were prepared by the metathetic reaction of trace heavy metals like Cd, Zn, Cu and Hg with two different dithioligands of the formula ML2 [M= Cd, Zn, Cu and Hg and L= potassium-1,1-dicyano-2,2-ethylenedithiolate and potassium

Synthesis, structural, DFT calculations and Hirshfeld surface analysis of (N-butyl-N-(4-fluorobenzyl)dithiocarbamato-S,S')-(thiocyanato-N)(triphenylphosphine)nickel(II) and preparation of nickel sulfide from nickel(II) dithiocarbamate

Bis(N-butyl-N-(4-fluorobenzyl)dithiocarbamato-S,S’)nickel(II) (1) and (N-butyl-N-(4-fluorobenzyl) dithiocarbamato-S,S’)(thiocyanato-N)(triphenylphosphine)-nickel(II) (2) have been prepared. Both the complexes have been characterized by elemental analyses, IR, electronic and 1H and 13C NMR spectroscopy. Single crystal X-ray analysis of complex 2 showed a distorted square planar configuration around the nickel atom due to steric effect of the triphenylphosphine and the bidentate chelation by two sulfur atoms of the dithiocarbamate ligand. UV-Vis spectral data of 1 and 2 are consistent with the formation of square planar nickel(II) complexes. Hirshfeld surface analysis was also carried out to provide qualitative and quantitative insights into the intermolecular interactions in 2. Molecular electrostatic potential surfacemap reveals that the negative charge is delocalized over S atoms of NCS2 and the positive charge is localized over N atom of NCS2 group. This indicates the considerable double bond character of the C-N (thioureide) bond. Nickel sulfide nanoparticles have been prepared from complex 1 and characterized using PXRD, EDS, UV-DRS, and SEM. EDS analysis confirm the formation of nickel sulfide.

Cs2CO3-Promoted Direct N-Alkylation: Highly Chemoselective Synthesis of N-Alkylated Benzylamines and Anilines

Herein is described an efficient and chemoselective method for the synthesis of diversely substituted secondary amines in yields up to 98 %. Direct mono-N-alkylation of primary benzylamines and anilines with a wide range of alkyl halides is promoted by a cesium base in the absence of any additive or catalyst. The basicity and solubility of cesium carbonate in anhydrous N,N-dimethylformamide not only enables mono-N-alkylation of primary amines but also suppresses undesired dialkylation of the desired amines.

Hydroamination of carbonyl compounds with oximes

N-alkyl(cycloalkyl)benzylamines, p-fluorobenzylamines, (1-phenylethyl) amines, [1-(p-fluorophenyl)ethyl]amines were synthesized by hydroamination of aldehydes and ketones with oximes.

NAD(P)H models XXII. Magnesium ion mediated acid catalysis of the reduction of imines by Hantzsch ester

Reduction of imines (2a-e) derived from n-butylamine and p-substituted benzaldehydes, in the presence of magnesium perchlorate, by Hantzsch ester (1), in acetonitrile, proceeds via the corresponding iminium salts formed by protonation of the imines by (2+) complexes.These complexes are produced by reaction of Mg(2+) ions with water, which is associated with the solvent acetonitrile.Within the range 1.67 x 10-3 - 26.11 x 10-3 M of added water, the rate of the reaction shows a direct dependence upon the concentration of water.Rates of reduction of the iminium perchlorates of 2a-e exhibit a Hammett relationship with a ρ value of +1.83.