60628-57-1

Basic information

• Product Name: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-5-phenyl-
• Synonyms: 2H-1,4-Benzodiazepin-2-one,7-chloro-3-fluoro-1,3-dihydro-5-phenyl;3-fluoro-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one;3-fluoro-1,3-dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one;7-chloro-3-fluoro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;3-Fluor-5-phenyl-7-chlor-2,3-dihydro-1H-1,4-benzodiazepin-2-on
• CAS NO: 60628-57-1
• Molecular Formula: C15H10ClFN2O
• Molecular Weight: 288.709
• Mol File: 60628-57-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 190-192 °C
• Boiling Point: 440.0±45.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-5-phenyl-(60628-57-1)
• EPA Substance Registry System: 2H-1,4-Benzodiazepin-2-one, 7-chloro-3-fluoro-1,3-dihydro-5-phenyl-(60628-57-1)

Safety Data

• Hazardous Substances Data: 60628-57-1(Hazardous Substances Data)

Upstream product

• 60628-89-9 3-fluoro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 359-22-8 bromo-fluoro-acetyl bromide 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 359-32-0 chlorofluoroacetyl chloride 
• 1074-82-4 potassium phtalimide 
• 7440-44-0 pyrographite 
• 604-75-1 oxazepam 
• 963-39-3 demoxepam 

Downstream Products

• 591-51-5 phenyllithium 
• 60628-55-9 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one 
• 62659-62-5 7-chloro-3-fluoro-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepine-1-carboxylic acid ethylamide 
• 62659-61-4 7-chloro-3-fluoro-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepine-1-carboxylic acid methylamide 
• 62659-56-7 1-allyl-7-chloro-3-fluoro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Relevant articles and documents

3-FLUOROBENZODIAZEPINES

Benzodiazepines that bear a fluorine substituent in the metabolically active C-3 position were prepared by the reaction of diethylaminosulfur trifluoride (DAST) with the corresponding 3-hydroxybenzodiazepines.These products are surprisingly stable to hydrolysis and possess potent antianxiety and muscle-relaxing properties.

3-Fluorobenzodiazepines

3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula STR1 wherein R1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8 carbon atoms; R2 is phenyl; monohalophenyl or pyridyl; R3 is F, Cl, Br or NO2, and physiologically acceptable acid addition salts thereof, are central nervous system depressants.