60710-80-7

Basic information

• Product Name: 3-AMINO-4-METHYLBENZONITRILE
• Synonyms: 5-Cyano-2-methylaniline, 2-Amino-4-cyanotoluene;3-AMINO-4-METHYLBENZONITRILE;Benzonitrile, 3-amino-4-methyl-;2-Amino-4-cyanotoluene
• CAS NO: 60710-80-7
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16
• Product Categories: Aromatic Nitriles;Nitrile
• Mol File: 60710-80-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 81 °C
• Boiling Point: 312.817°C at 760 mmHg
• Flash Point: 142.987°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2?+-.0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-4-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-METHYLBENZONITRILE(60710-80-7)
• EPA Substance Registry System: 3-AMINO-4-METHYLBENZONITRILE(60710-80-7)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 60710-80-7(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline

InChI:InChI=1/C8H8N2/c1-6-2-3-7(5-9)4-8(6)10/h2-4H,10H2,1H3

Upstream product

• 74-90-8 hydrogen cyanide 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 2458-12-0 3-amino-p-toluic acid 
• 19406-86-1 3-Amino-4-methyl-benzamide 
• 874-86-2 4-cyanobenzyl chloride 
• 104-85-8 para-methylbenzonitrile 
• 39478-78-9 5-bromo-2-methylaniline 
• 557-21-1 dicyanozinc 
• 90178-80-6 4-(chloromethyl)-3-nitrobenzonitrile 
• 939-79-7 4-cyano-2-nitrotoluene 

Downstream Products

• 347196-39-8 2-Chloro-N-(5-cyano-2-methylphenyl)acetamide 
• 372198-49-7 5-cyano-2-methylbenzene-1-sulfonyl chloride 
• 1426449-78-6 N-(5-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)-6-(((triisopropylsilyl)oxy)methyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426449-99-1 tert-butyl 4-(3-((5-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)carbamoyl)imidazo[1,2-a]pyridin-7-yl)piperidine-1-carboxylate 
• 1426449-54-8 N-(5-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)-7-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426449-84-4 6-acetyl-N-(5-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-28-3 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-(hydroxymethyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-29-4 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-31-8 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-40-9 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-7-(1-methanesulfonylpiperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-44-3 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-(3-oxobutyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-45-4 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-(3-hydroxy-3-methylbutyl)imidazo[1,2-a]pyridine-3-carboxamide 
• 1426448-53-4 3-N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}imidazo[1,2-a]pyridine-3,6-dicarboxamide 
• 1426448-54-5 N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[2-(4-methylpiperazin-1-yl)ethyl]imidazo[1,2-a]pyridine-3-carboxamide 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Efficient cyanation of aryl bromides with K4[Fe(CN)6] catalyzed by a palladium-indolylphosphine complex

This study describes a general palladium-catalyzed cyanation of aryl bromides using K4[Fe(CN)6] as the cyanide surrogate. The reactions can be successfully conducted under mild reaction conditions (at 50 °C) in mixed solvents (water/MeCN = 1:1) without any surfactant additives, and afford the desired aryl nitriles in good-to-excellent yields. Particularly noteworthy is that this system allows the mildest reaction temperature reported so far for palladium-catalyzed cyanation of aryl bromides with K 4[Fe(CN)6] source in general. Common functional groups, including keto, aldehyde, free amine, and heterocyclic substrates are compatible under this system. Interestingly, the phosphine ligands bearing -PCy 2 moiety, which usually show excellent activity in aryl halide couplings, are found less effective than the corresponding ligands with -PPh2 group.

IDENTIFICATION OF COMPOUNDS SUITABLE FOR TREATING AD

The invention provides a method of screening for compounds which inhibit the hyperphosphorylation of tau, and hence are suitable for treating AD and related conditions.