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Phenol, 3,4-diamino-, also known as 3,4-diaminophenol, is a chemical compound belonging to the group of 3,4-diaminophenols. It is characterized by the presence of two amino groups attached to the 3 and 4 positions of a phenol molecule. Phenol, 3,4-diaminois known for its versatile applications in various industries, including hair dye production, azo dye synthesis, pharmaceutical manufacturing, and organic electronics. However, due to its toxic nature and potential harmful effects on human health and the environment, it is crucial to handle Phenol, 3,4-diaminowith proper safety measures and precautions.

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  • 615-72-5 Structure
  • Basic information

    1. Product Name: Phenol, 3,4-diaMino-
    2. Synonyms: Phenol, 3,4-diaMino-;Esomeprazole Impurity 12
    3. CAS NO:615-72-5
    4. Molecular Formula: C6H8N2O
    5. Molecular Weight: 124.14052
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 615-72-5.mol
  • Chemical Properties

    1. Melting Point: 170-172 °C
    2. Boiling Point: 356.5±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.343±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
    9. PKA: 10.28±0.18(Predicted)
    10. CAS DataBase Reference: Phenol, 3,4-diaMino-(CAS DataBase Reference)
    11. NIST Chemistry Reference: Phenol, 3,4-diaMino-(615-72-5)
    12. EPA Substance Registry System: Phenol, 3,4-diaMino-(615-72-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 615-72-5(Hazardous Substances Data)

615-72-5 Usage

Uses

Used in Hair Dye Industry:
Phenol, 3,4-diaminois used as a key ingredient in the production of hair dyes. It is known for its ability to react with hair proteins, resulting in a permanent color change. Phenol, 3,4-diaminoprovides a wide range of color options and is often used in combination with other chemicals to achieve desired shades and tones.
Used in Azo Dye Synthesis:
In the dye industry, Phenol, 3,4-diaminoserves as an essential precursor in the synthesis of azo dyes. Azo dyes are a class of organic compounds characterized by the presence of one or more azo groups (-N=N-). These dyes are widely used in various applications, such as textiles, plastics, and printing inks, due to their vibrant colors and excellent lightfastness.
Used in Pharmaceutical Manufacturing:
Phenol, 3,4-diaminois utilized in the synthesis of certain pharmaceuticals, particularly those with therapeutic applications. Its unique chemical structure allows for the development of drugs with specific properties, such as antimicrobial, anti-inflammatory, or analgesic effects. Phenol, 3,4-diamino-'s versatility in chemical reactions makes it a valuable building block in the pharmaceutical industry.
Used in Organic Electronics:
Phenol, 3,4-diaminohas potential applications in the field of organic electronics, where it can be used as a component in the development of organic semiconductors, organic light-emitting diodes (OLEDs), and other electronic devices. Its ability to form stable complexes with other molecules and its electronic properties make it a promising candidate for use in these advanced technologies.

Check Digit Verification of cas no

The CAS Registry Mumber 615-72-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 615-72:
(5*6)+(4*1)+(3*5)+(2*7)+(1*2)=65
65 % 10 = 5
So 615-72-5 is a valid CAS Registry Number.

615-72-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-Diaminophenol

1.2 Other means of identification

Product number -
Other names 5-hydroxy-1,2-phenylenediamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:615-72-5 SDS

615-72-5Relevant articles and documents

Synthesis and X-Ray analysis of new 1,5-benzo-diazepinium picrates

Schmidt, Andreas,Shilabin, Abbas Gholipour,Nieger, Martin

, p. 2645 - 2651 (2003)

1,2-Diaminobenzenes react with pentane-2,4-dione in ethanol in the presence of picric acid to give 1,5-benzodiazepinium picrates. In the single crystal, the benzodiazepinium molecules form layers with overlapped 7-membered rings in head-to-tail arrangemen

Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs

Sasaki, Eita,Kojima, Hirotatsu,Nishimatsu, Hiroaki,Urano, Yasuteru,Kikuchi, Kazuya,Hirata, Yasunobu,Nagano, Tetsuo

, p. 3684 - 3685 (2005)

Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency w

A combined mechanochemical and calcination route to mixed cobalt oxides for the selective catalytic reduction of nitrophenols

Shultz, Lorianne R.,McCullough, Bryan,Newsome, Wesley J.,Ali, Haider,Shaw, Thomas E.,Davis, Kristopher O.,Uribe-Romo, Fernando J.,Baudelet, Matthieu,Jurca, Titel

, (2020)

Para-, or 4-nitrophenol, and related nitroaromatics are broadly used compounds in industrial processes and as a result are among the most common anthropogenic pollutants in aqueous industrial efiuent; this requires development of practical remediation str

Liquid-crystalline perylene diester polymers with tunable charge-carrier mobility

Muth, Mathis-Andreas,Carrasco-Orozco, Miguel,Thelakkat, Mukundan

, p. 4510 - 4518 (2011)

New classes of liquid-crystalline semiconductor polymers based on perylene diester benzimidazole and perylene diester imide mesogens are reported. Two highly soluble side-chain polymers, poly(perylene diester benzimidazole acrylate) (PPDB) and poly(peryle

Galactose Grafted Two-Dimensional Nanosheets as a Scaffold for the In Situ Synthesis of Silver Nanoparticles: A Potential Catalyst for the Reduction of Nitroaromatics

Harikrishnan, Kaloor S.,Krishnan, Nithiyanandan,Kumar, Nilima Manoj,Krishna, Anusree,Raj, Gowtham,Perumal, Devanathan,Kalathil, Jemshiya,Krishna, Jithu,Varghese, Reji

, p. 14100 - 14107 (2021/09/06)

Two major hurdles in NP-based catalysis are the aggregation of the NPs and their recycling. Immobilization of NPs onto a 2D support is the most promising strategy to overcome these difficulties. Herein, amphiphilicity-driven self-assembly of galactose-hexaphenylbenzene-based amphiphiles into galactose-decorated 2D nanosheet is reported. The extremely dense decoration of reducing sugar on the surface of the sheets is used for the in situ synthesis and immobilization of ultrafine catalytically active AgNPs by using Tollens’ reaction. The potential of the system as a catalyst for the reduction of various nitroaromatics is demonstrated. Enhanced catalytic activity is observed for the immobilized AgNPs when compared to the corresponding discrete AgNPs. Recovery of the catalytic system from the reaction mixture by ultrafiltration and its subsequent recycling for several cycles without dropping its activity is shown. This is the first report demonstrating the in situ synthesis and immobilization of ultrafine AgNPs onto a 2D nanosheet that exhibits excellent catalytic performance for the reduction of nitroaromatics.

Synthesis of CoFe2O4@Pd/Activated carbon nanocomposite as a recoverable catalyst for the reduction of nitroarenes in water

Hamadi, Hosein,Kazeminezhad, Iraj,Mohammadian, Sara

, (2021/07/06)

Efficient reduction of nitro compounds into amines is an important industrial transformation. So, it is a great deal to design new catalysts for efficient reduction of the nitro compounds especially in water. In this work, a new magnetic Pd/activated carbon nanocomposite (CoFe2O4@Pd/AC) was synthesized via metal-impregnation-pyrolysis method. The CoFe2O4@Pd/AC was fully characterized by FT-IR, PXRD, FESEM, TEM, VSM, EDX-mapping and BET techniques. The results showed that CoFe2O4@Pd/AC is a highly reactive and easily recoverable magnetic catalyst for the reduction of the nitro compounds by using NaBH4 in water. For instance, aniline was obtained in high yield (99%) after 75 ?min at 25 ?C by using just 6 ?mg of the catalyst. In addition, CoFe2O4@Pd/AC was recovered by a simple magnetic decantation and it exhibits stable activity and remains intact during the catalytic process with no significant loss in activity (8 cycles).

Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities

Zhang, Huijun,Fang, Xiong,Meng, Qian,Mao, Yujia,Xu, Yan,Fan, Tingting,An, Jing,Huang, Ziwei

supporting information, p. 380 - 396 (2018/08/17)

Microtubule has been an important target for anticancer drug development. Here we report the discovery and characterization of a series of fused 4-aryl-4H-chromene-based derivatives as highly potent microtubule inhibitors. Among a total of 37 derivatives synthesized, 23 exhibited strong in vitro anti-proliferative activities against A375 human melanoma cells. The relationship between the biological activities of these microtubule inhibitors and their chemical structure variations was analyzed. Studies of compounds 27a, 19a and 9a in parallel with colchicine as the positive control compound in a panel of biological assays revealed that these compounds blocked cell cycle progression, increased apoptosis, and inhibited HUVEC capillary tube formation at low nanomolar concentrations. The most potent compound 27a was also tested in eight additional cancer cell lines besides A375 cells and two non-cancer cells and showed potent and selective activity on these cancer cells. To understand the molecular and structure mechanism of action of these compounds, tubulin polymerization and molecular docking studies were carried out for 27a as the representative. The results were consistent with the mechanism by which 27a interacts with the colchicine binding site on tubulin and disrupts tubulin polymerization. With potent dual actions of microtubule destabilization and vascular disruption described above, this small molecule can serve as a valuable research probe of the function and role of microtubules in human diseases and promising lead for developing new therapeutic agents.

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

Mao, Ruifeng,Shao, Jingwei,Zhu, Kongkai,Zhang, Yuanyuan,Ding, Hong,Zhang, Chenhua,Shi, Zhe,Jiang, Hualiang,Sun, Dequn,Duan, Wenhu,Luo, Cheng

, p. 6289 - 6304 (2017/08/02)

PRMT5 plays important roles in diverse cellular processes and is upregulated in several human malignancies. Besides, PRMT5 has been validated as an anticancer target in mantle cell lymphoma. In this study, we found a potent and selective PRMT5 inhibitor by performing structure-based virtual screening and hit optimization. The identified compound 17 (IC50 = 0.33 μM) exhibited a broad selectivity against a panel of other methyltransferases. The direct binding of 17 to PRMT5 was validated by surface plasmon resonance experiments, with a Kd of 0.987 μM. Kinetic experiments indicated that 17 was a SAM competitive inhibitor other than the substrate. In addition, 17 showed selective antiproliferative effects against MV4-11 cells, and further studies indicated that the mechanism of cellular antitumor activity was due to the inhibition of PRMT5 mediated SmD3 methylation. 17 may represent a promising lead compound to understand more about PRMT5 and potentially assist the development of treatments for leukemia indications.

Effect of Extended Benzannelation Orientation on Bergman and Related Cyclizations of Isomeric Quinoxalenediynes

Valenzuela, Stephanie A.,Cortés, Alondra J.,Tippins, Zakery J. E.,Daly, Morgan H.,Keel, Terell E.,Gherman, Benjamin F.,Spence, John D.

, p. 13297 - 13312 (2017/12/26)

A combined computational and experimental study was conducted to examine the effect of extended benzannelation orientation on C1-C5 and C1-C6 cyclization of acyclic quinoxalenediynes. Calculations (mPW1PW91/cc-p

Aralkylpiperidine (or piperazinecarboxylic) and its derivatives used for treating hypercalcemia schinzopherenia

-

Page/Page column 31, (2018/12/01)

PROBLEM TO BE SOLVED: To provide an agent for treating schizophrenia and related neuropsychiatric diseases.SOLUTION: This invention provides an aralkylpiperidine (or piperazine) derivative represented by formula (1), where A ring is a 5-7 membered heterocycle including N, with the heterocycle including a hetero atom arbitrarily selected from O, S, N; X is O, an amino group or a substituted amino group; Z is CH, N or C; Y is O, N or S; n is an integer of 1-5; and R1-R6 are H, a C1-C4 alkyl group or the like.

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