61675-94-3

Basic information

• Product Name: Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate
• Synonyms: Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate;[(Tetrahydropyran-2-yl)oxy]acetic acid ethyl ester;O-(Tetrahydro-2H-pyran-2-yl)glycolic acid ethyl ester;[(Tetrahydropyran-2-yl)oxy]acetic acid ethyl ester O-(Tetrahydro-2H-pyran-2-yl)glycolic acid ethyl ester;ethyl (tetrahydro-2H-pyran-2-yloxy)acetate
• CAS NO: 61675-94-3
• Molecular Formula: C₉H₁₆O₄
• Molecular Weight: 188.22094
• Product Categories: Miscellaneous Reagents
• Mol File: 61675-94-3.mol

Chemical Properties

• Boiling Point: 88℃ (1 Torr)
• Flash Point: 121.8°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.00321mmHg at 25°C
• Refractive Index: 1.4440 (589.3 nm 16℃)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate(61675-94-3)
• EPA Substance Registry System: Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate(61675-94-3)

Safety Data

• Hazardous Substances Data: 61675-94-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-((Tetrahydro-2H-pyran-2-yl)oxy)acetate is used as a reactant for the synthesis of 3-phenylpyrazolo[1,5-a]pyrimidine, a potent corticotropin-releasing factor-1 (CRF-1) antagonist. This application is significant because CRF-1 antagonists have potential therapeutic applications in treating stress-related disorders, anxiety, and depression.

InChI:InChI=1/C9H16O4/c1-2-11-8(10)7-13-9-5-3-4-6-12-9/h9H,2-7H2,1H3

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 623-50-7 ethyl 2-hydroxyacetate 
• 142-68-7 TETRAHYDROPYRANE 

Downstream Products

• 123492-33-1 ((2R,3R,5S,6R)-6-Benzyloxymethyl-2-hydroxy-5-methoxy-3-methyl-tetrahydro-pyran-2-yl)-[(tetrahydro-pyran-2-yloxy)]-acetic acid ethyl ester 
• 91073-91-5 2-phenyl-5-(tetrahydro-2-pyranyloxy)-4-pyrimidinone 
• 24614-14-0 5-hydroxy-2-methyl-(3H)-pyrimidin-4-one 
• 1417817-97-0 2-[(phenylsulfanyl)methyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one 
• 1417817-45-8 2-[(3-chlorobenzyl)sulfanyl]-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one 
• 1417818-03-1 2-(2-phenylethyl)-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4(3H)-one 
• 1003946-50-6 (E)-2-styryl-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4-yl trifluoromethanesulfonate 
• 1003946-51-7 (E)-2-styryl-5-(tetrahydro-2H-pyran-2-yloxy)pyrimidin-4-amine 
• 1245931-96-7 1-((tetrahydro-2H-pyran-2-yloxy)methyl)cyclopropyl benzoate 
• 1117699-25-8 (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydro-pyran-2-yloxy)acrylic acid monopotassium salt 
• 1117699-24-7 ethyl (2Z)-3-(4-benzyloxy-3,5-dimethyl-phenyl)-2-(tetrahydropyran-2-yloxy)acrylate 
• 1003946-49-3 2-[(E)-2-phenylethenyl]-5-(tetrahydro-2H-pyran-2-yloxy)-4(1H)-pyrimidinone 

Relevant articles and documents

HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS

The present teachings relate to hydroxypyridinone and hydroxypyrimidinone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.

AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE

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The present invention relates to indole compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.

BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Novel bridged bicyclic compounds are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antibacterial agents. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating bacterial infections and associated diseases and conditions.

NOVEL PREPARATION PROCESS

A process for preparing compounds of the formula (I) in which R1 and R2 are as defined in the description.

AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

COMPOUNDS AND METHODS OF USE

The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS

The invention provides a new class of strongly chelating multidentate ligands based on a 2-hydroxy-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid scaffold (hereafter 1,2-HOIQO) in combination with polyamine backbones. The extremely stable bidentate 1,2- HOIQO moiety can be synthesized by standard synthetic methodology on a large scale. An advantageous feature is the possibility to introduce a wide range of substituents on the benzene ring by standard transformations (like electrophilic aromatic substitutions). This allows, for example, for the tuning of chemical, photophysical, and solubility properties, as well as the attachment of functional moieties, relevant for sensing and imaging applications (e.g. DNA, proteins, antibodies, fluorophores, etc.). The combination of the 1,2-HOIQO chelators with polyamine backbones provides very strongly binding ligands for a variety of metals including first-row transition metals, lanthanides, actinides, etc. Metal complexes of this kind are expected to be useful in a number of applications (e.g. luminescence, MRI, actinide sequestering, metal chelation therapy, metal radioisotope labeling, etc.).

Hydroxypyridonate and hydroxypyrimidinone chelating agents

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