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62802-42-0

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62802-42-0 Usage

Chemical Properties

Colorless to light yellow liquid

Uses

Different sources of media describe the Uses of 62802-42-0 differently. You can refer to the following data:
1. 2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.
2. 2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

Preparation

Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

Check Digit Verification of cas no

The CAS Registry Mumber 62802-42-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,8,0 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 62802-42:
(7*6)+(6*2)+(5*8)+(4*0)+(3*2)+(2*4)+(1*2)=110
110 % 10 = 0
So 62802-42-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClFNO2/c7-5-4(8)3(6(10)11)1-2-9-5/h1-2H,(H,10,11)

62802-42-0 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H55055)  2-Chloro-5-fluoropyrimidine, 97%   

  • 62802-42-0

  • 250mg

  • 522.0CNY

  • Detail
  • Alfa Aesar

  • (H55055)  2-Chloro-5-fluoropyrimidine, 97%   

  • 62802-42-0

  • 1g

  • 1699.0CNY

  • Detail
  • Alfa Aesar

  • (H55055)  2-Chloro-5-fluoropyrimidine, 97%   

  • 62802-42-0

  • 5g

  • 8497.0CNY

  • Detail
  • Aldrich

  • (651753)  2-Chloro-5-fluoropyrimidine  97%

  • 62802-42-0

  • 651753-250MG

  • 730.08CNY

  • Detail
  • Aldrich

  • (651753)  2-Chloro-5-fluoropyrimidine  97%

  • 62802-42-0

  • 651753-1G

  • 1,798.29CNY

  • Detail

62802-42-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-5-fluoropyrimidine

1.2 Other means of identification

Product number -
Other names 2-chloro-5-fluoropyrimidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62802-42-0 SDS

62802-42-0Relevant articles and documents

IMIDAZOTRIAZINONE COMPOUNDS

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Paragraph 0639; 0640; 0641, (2013/10/08)

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME

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Page/Page column 92-93, (2008/06/13)

Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists

-

, (2019/08/08)

Compounds represented by Formula (I): 1or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.

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