628691-93-0

Basic information

• Product Name: 2-CHLORO-3-FLUOROISONICOTINIC ACID
• Synonyms: 2-CHLORO-3-FLUOROISONICOTINIC ACID;2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID;2-Chloro-3-fluoropyridine-4-carboxylic acid, 4-Carboxy-2-chloro-3-fluoropyridine;2-Chloro-3-Fluoroisonicotinic Acid(WX614144)
• CAS NO: 628691-93-0
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.54
• EINECS: -0
• Product Categories: Boronic Acid;Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Pyridines
• Mol File: 628691-93-0.mol

Chemical Properties

• Melting Point: 199 °C (dec.)
• Boiling Point: 389.145 °C at 760 mmHg
• Flash Point: 189.148 °C
• Appearance: /
• Density: 1.577 g/cm³
• Vapor Pressure: 0.00604mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Room temperature.
• PKA: 2.07±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-FLUOROISONICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-FLUOROISONICOTINIC ACID(628691-93-0)
• EPA Substance Registry System: 2-CHLORO-3-FLUOROISONICOTINIC ACID(628691-93-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 628691-93-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-fluorisonicotinic acid is used as an intermediate in the synthesis of pharmaceuticals for its potential applications in the development of biologically active molecules. Its unique structural features allow for the creation of new compounds with therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-chloro-3-fluorisonicotinic acid is utilized as an intermediate in the synthesis of various agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Organic Chemistry Research:
2-Chloro-3-fluorisonicotinic acid serves as a valuable building block in organic chemistry, enabling researchers to explore its reactivity and potential applications in the synthesis of novel organic compounds.
Used in Medicinal Chemistry:
As a component in medicinal chemistry, 2-chloro-3-fluorisonicotinic acid is employed for structure-activity relationship studies, aiding in the design and optimization of new drug candidates with improved pharmacological properties.

InChI:InChI=1/C7H4ClF3N2O2/c8-3-1-4(7(9,10)11)6(12)5(2-3)13(14)15/h1-2H,12H2

Upstream product

• 17282-04-1 2-chloro-3-fluoropyridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 628691-95-2 methyl 2-chloro-3-fluoropyridine-4-carboxylate 
• 1269421-86-4 2-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-3-fluoroisonicotinamide 
• 1269421-87-5 N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide 
• 1269421-88-6 4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide 
• 1269420-88-3 4-amino-N-(2-chloro-6-fluoro-3-(propylsulfonamido)phenyl)-pyrido[3,2-d]pyrimidine-8-carboxamide 
• 1227577-03-8 2-chloro-3-fluoro-pyridin-4-ylamine 
• 1365991-98-5 2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-6-fluorobenzimidoyl chloride 
• 1242249-93-9 4-chloro-2-(2-chloro-6-fluoro-phenyl)-thiazolo[5,4-c]pyridine 
• 1365989-46-3 (2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol 
• 1365992-00-2 2,6-dichloro-N-(2-chloro-3-fluoro-pyridin-4-yl)benzamide 
• 1365992-01-3 2,6-dichloro-N-(2-chloro-3-fluoropyridin-4-yl)benzimidoyl chloride 
• 1242254-41-6 4-chloro-2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine 
• 1365989-47-4 2-[2-(2,6-dichloro-4-cyanophenyl)-thiazolo[5,4-c]pyridine-4-ylamino]-isonicotinonitrile 
• 1365992-02-4 2,6-dichloro-N-(2-chloro-3-fluoropyridin-4-yl)-4-cyano-benzamide 

Relevant articles and documents

DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM

The present invention is directed to diarylmethylamide derivatives represented of structural formula I which are melanin-concentrating hormone receptor antagonists, and are useful as an agent for the prevention, treatment, or remedy of various circulatory diseases, neurological diseases, metabolic diseases, reproductive system diseases, respiratory diseases, digestive diseases, and the like. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the melanin-concentrating hormone is involved. I

Morpholine type cinnamide compound

The present invention relates to a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein R1, R2, R3, and R4 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group; X1 represents a C1-6 alkylene group that may be substituted; Xa represents a methoxy group or a fluorine atom; Xb represents an oxygen atom or a methylene group, provided that Xb is only an oxygen atom when Xa is a methoxy group; and Ar1 represents an aryl group, pyridinyl group, aryloxy group, or pyridinyloxy group that may have a substituent such as a halogen atom; and to use of the compound or salt as a pharmaceutical agent.

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.