6312-26-1Relevant articles and documents
Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition
Abou-Shehada, Sarah,Teasdale, Matthew C.,Bull, Steven D.,Wade, Charles E.,Williams, Jonathan M. J.
, p. 1083 - 1087 (2015/03/30)
A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.
SYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIDINES AND DIPYRIDYL-SUBSTITUTED COMPOUNDS WITH THE AID OF LOW-VALENCE COMPOLEXES
Selimov, F. A.,Khafizov, V. R.,Dzhemilev, U. M.
, p. 290 - 295 (2007/10/02)
The possibility of the preparation of oxygen, nitrogen, and sulfur-containing pyridines and dipyridyl-substituted compounds by the cyclocotrimerization of substituted propionitriles with acetylene under the influence of a Co(2-ethylhexanoate)2-Al(C2H5)3 catalyst was demonstrated.It was established that the nature of the heteroatom in substituted propionitriles has virtually no effect on the direction of the reaction.