64585-18-8Relevant articles and documents
Electrochemical oxidation by square-wave potential pulses in the imitation of oxidative drug metabolism
Nouri-Nigjeh, Eslam,Permentier, Hjalmar P.,Bischoff, Rainer,Bruins, Andries P.
, p. 5519 - 5525 (2011)
Electrochemistry combined with mass spectrometry (EC-MS) is an emerging analytical technique in the imitation of oxidative drug metabolism at the early stages of new drug development. Here, we present the benefits of electrochemical oxidation by square-wa
Studying drug metabolic oxidation with biomimetic metalloporphyrin systems : Problems and solutions in the case of lidocaine
Carrier, M. N.,Battioni, P.,Mansuy, D.
, p. 405 - 416 (2007/10/02)
The oxidation of the drug lidocaine 1 (2,2-diethylamino-2',6'-dimethylacetanilide) by various metalloporphyrin systems mimicking cytochrome P450 was studied.Systems using H2O2 or PhIO as oxidants and several homogeneous or supported Fe(III)- or Mn(III)-po
Quantification of lidocaine and several metabolites utilizing chemical ionization mass spectrometry and stable isotope labeling
Nelson,Garland,Breck,Trager
, p. 1180 - 1190 (2007/10/05)
Quantification of the suspected metabolites of lidocaine in humans was carried out using the direct insertion probe and chemical-ionization mass spectrometry. Deuterated analogs of the metabolites of lidocaine were added to serial human plasma and urine s