65081-24-5Relevant articles and documents
NHC/Iron cooperative catalysis: Aerobic oxidative esterification of aldehydes with phenols
Reddy, R. Sudarshan,Rosa, Joao N.,Veiros, Luis F.,Caddick, Stephen,Gois, Pedro M. P.
supporting information; experimental part, p. 3126 - 3129 (2011/05/12)
An NHC/iron cooperative catalytic system mediates the aerobic oxidative esterification of aldehydes with phenols. The use of equimolar amounts of reactants led to good to excellent isolated yields of esters.
Selective synthesis of 3,4-dihydrocoumarins and chalcones from substituted aryl cinnamic esters
Jeon, Jae-Ho,Yang, Deok-Mo,Jun, Jong-Gab
experimental part, p. 65 - 70 (2011/10/31)
Coumarins are ubiquitous in plant kingdom and have been used as antitumor, antifungals, anticoagulants, insecticides. Chalcones are also widespread in plant kingdom and have been known to possess diverse biological activities; antibacterial, antifungal, antitumor and anti-inflammatory, etc. As they are considered as important natural products, numerous synthetic approaches have been reported up to the present. We devise a new selective method of preparing dihydrocoumarins and chalcones from aryl cinnamates by the selection of reagents. Dihydrocoumarin derivatives were prepared selectively by using intramolecular cyclization catalyzed by p-toluene sulfonic acid. Also, chalcones were prepared by Fries-rearrangement catalyzed by TiCl4. This method can be used for preparing various coumarin & chalcone compounds.
