64919-59-1

Upstream product

• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 100-52-7 benzaldehyde 
• 108-39-4 3-methyl-phenol 
• 102-92-1 cinnamoyl chloride 
• 65081-24-5 3-methylphenyl cinnamate 

Downstream Products

• 81819-86-5 2-(1,5-Diphenyl-4,5-dihydro-1H-pyrazol-3-yl)-5-methyl-phenol 
• 107095-38-5 5-Methyl-2-(5-phenyl-3,4-dihydro-2H-pyrazol-3-yl)-phenol 
• 107095-27-2 5-Methyl-2-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-phenol 
• 107095-30-7 1-[3-(2-Hydroxy-4-methyl-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone 
• 50400-64-1 7-methylflavone 
• 64919-60-4 7-methyl-2-phenylchroman-4-one 
• 1162693-00-6 C₁₆H₁₄O 
• 107095-34-1 Acetic acid 2-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-5-methyl-phenyl ester 
• 107095-43-2 Acetic acid 5-methyl-2-(5-phenyl-3,4-dihydro-2H-pyrazol-3-yl)-phenyl ester 

Relevant academic research and scientific papers

Substituent-Controlled Divergent Cascade Cycloaddition Reactions of Chalcones and Arylalkynols: Access to Spiroketals and Oxa-Bridged Fused Heterocycles

Herein, we report substituent-controlled divergent cascade cycloaddition reactions of chalcones and arylalkynols in the presence of PtI2. Depending on the substituent on the chalcone, either spiroketals or oxa-bridged fused heterocycles could be obtained in the ranges of 86–97% and 87–95% yields under identical reaction conditions. Control experiments were carried out to elucidate the origin of the high chemoselectivity. These provide a method for the synthesis of a diverse array of structurally complex oxygen-containing heterocycles. (Figure presented.).

Selective synthesis of 3,4-dihydrocoumarins and chalcones from substituted aryl cinnamic esters

Coumarins are ubiquitous in plant kingdom and have been used as antitumor, antifungals, anticoagulants, insecticides. Chalcones are also widespread in plant kingdom and have been known to possess diverse biological activities; antibacterial, antifungal, antitumor and anti-inflammatory, etc. As they are considered as important natural products, numerous synthetic approaches have been reported up to the present. We devise a new selective method of preparing dihydrocoumarins and chalcones from aryl cinnamates by the selection of reagents. Dihydrocoumarin derivatives were prepared selectively by using intramolecular cyclization catalyzed by p-toluene sulfonic acid. Also, chalcones were prepared by Fries-rearrangement catalyzed by TiCl4. This method can be used for preparing various coumarin & chalcone compounds.

A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors

A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.