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CAS

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65473-13-4

N-Methyl-1-naphthalenemethylamine hydrochloride, also known as Terbinafine BP Impurity A and Terbinafine USP Related Compound A, is an off-white powder that serves as an intermediate in the synthesis of various pharmaceuticals. It plays a crucial role in the production of medications such as Terbinafine hydrochloride (T107500) and Butenafine hydrochloride (B690195).

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  • 65473-13-4 Structure

  • Basic information

    1. Product Name: N-Methyl-1-naphthalenemethylamine hydrochloride
    2. Synonyms: 1-METHYL-AMINOMETHYL NAPHTHALENE HCL;1-(METHYLAMINOMETHYL)NAPHTHALENE HYDROCHLORIDE;N-METHYL-2-NAPHTHALENE-METHANAMINE HCL;N-METHYL NAPHTHYLMETHYL AMINO HCL;N-METHYL-1-NAPHTHALENEMETHYL AMINE HCL;N-METHYL-1-NAPHTHALENEMETHYLAMINE HYDROCHLORIDE;N-METHYL-1-NAPHTHYLENEMETHYLAMINE HCL;N-METHYL-1-NAPHTHYLMETHYL AMINE HCL
    3. CAS NO:65473-13-4
    4. Molecular Formula: C12H13N*ClH
    5. Molecular Weight: 207.7
    6. EINECS: 1592732-453-0
    7. Product Categories: PHARMACEUTICAL INTERMEDIATES;Naphthalene derivatives;Naphthalene series;Amine Salts;Nitrogen Compounds;Organic Building Blocks;Terbinafine
    8. Mol File: 65473-13-4.mol

  • Chemical Properties

    1. Melting Point: 191-193 °C(lit.)
    2. Boiling Point: 287.9 °C at 760 mmHg
    3. Flash Point: 146.7 °C
    4. Appearance: off-white powder
    5. Density: 1,05g/cm
    6. Vapor Pressure: 0.00242mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: Indoors
    9. Solubility: N/A
    10. Water Solubility: soluble
    11. Merck: 14,9171
    12. CAS DataBase Reference: N-Methyl-1-naphthalenemethylamine hydrochloride(CAS DataBase Reference)
    13. NIST Chemistry Reference: N-Methyl-1-naphthalenemethylamine hydrochloride(65473-13-4)
    14. EPA Substance Registry System: N-Methyl-1-naphthalenemethylamine hydrochloride(65473-13-4)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-37/39-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 65473-13-4(Hazardous Substances Data)

65473-13-4 Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-1-naphthalenemethylamine hydrochloride is used as a synthetic intermediate for the production of various pharmaceuticals. Its primary application is in the synthesis of Terbinafine hydrochloride (T107500) and Butenafine hydrochloride (B690195), which are widely used in the treatment of fungal infections. N-Methyl-1-naphthalenemethylamine hydrochloride's role in the pharmaceutical industry is essential for the development and manufacturing of these medications, contributing to the overall healthcare sector.

Check Digit Verification of cas no

The CAS Registry Mumber 65473-13-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,7 and 3 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 65473-13:
(7*6)+(6*5)+(5*4)+(4*7)+(3*3)+(2*1)+(1*3)=134
134 % 10 = 4
So 65473-13-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H13N/c1-13-9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8,13H,9H2,1H3/p+1

65473-13-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Alfa Aesar

  • (H28719)  N-Methyl-1-naphthalenemethylamine hydrochloride, 98%   

  • 65473-13-4

  • 1g

  • 580.0CNY

  • Detail

  • Alfa Aesar

  • (H28719)  N-Methyl-1-naphthalenemethylamine hydrochloride, 98%   

  • 65473-13-4

  • 10g

  • 2917.0CNY

  • Detail

  • USP

  • (1424608)  TerbinafineRelatedCompoundA  United States Pharmacopeia (USP) Reference Standard

  • 65473-13-4

  • 1424608-25MG

  • 14,578.20CNY

  • Detail

  • Aldrich

  • (262315)  N-Methyl-1-naphthalenemethylaminehydrochloride  98%

  • 65473-13-4

  • 262315-1G

  • 431.73CNY

  • Detail

65473-13-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Methyl-1-naphthalenemethylamine hydrochloride

1.2 Other means of identification

Product number -
Other names N-methyl-1-naphthalen-1-ylmethanamine,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65473-13-4 SDS

65473-13-4Relevant articles and documents

Synthesis of potential inhibitors of squalenepoxidase with conformationanl fixation of the structural elements of Butenafine

Stanetty,Wallner

, p. 341 - 350 (2007/10/02)

The synthesis of the naphthalinemethanamines 6b-h is reported. To obtain products with conformative rigidity, substituents with gradually increased space demand were placed into the α-position. Since the direct reductive amination of the naphthylalkanones 3 with the amines 9 or 10 was only of very limited use the α-substituted naphthalinmethanamines 2 and 4 were synthesized as useful intermediates by various methods and the desired N-substitution pattern of the target compounds was subsequently built up applying - mostly reductive - alkylation methods.

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