658-27-5

Basic information

• Product Name: (3-FLUOROPHENYL)HYDRAZINE
• Synonyms: (3-FLUOROPHENYL)HYDRAZINE;AKOS BBS-00006970;1-(3-Fluorophenyl)hydrazine
• CAS NO: 658-27-5
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.13
• Mol File: 658-27-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 28 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 88 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.06±0.10(Predicted)
• CAS DataBase Reference: (3-FLUOROPHENYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-FLUOROPHENYL)HYDRAZINE(658-27-5)
• EPA Substance Registry System: (3-FLUOROPHENYL)HYDRAZINE(658-27-5)

Safety Data

• Hazardous Substances Data: 658-27-5(Hazardous Substances Data)

Usage

General Description

(3-Fluorophenyl)hydrazine is a chemical compound with the formula C6H5FN2. It is a hydrazine derivative with a fluorine atom attached to a phenyl ring. (3-FLUOROPHENYL)HYDRAZINE has a variety of uses in organic synthesis, particularly in the pharmaceutical industry where it can be used as a building block for the synthesis of various pharmaceutical compounds. It can also serve as a reagent in the preparation of other organic compounds by reacting with carbonyl compounds to form hydrazones. Additionally, (3-Fluorophenyl)hydrazine has potential applications in the field of agrochemicals and can also be used as a precursor for the synthesis of various biologically active molecules. However, it is important to handle this compound with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 372-19-0 meta-fluoroaniline 

Downstream Products

• 454-17-1 D-arabino-[2]hexosulose-bis-(3-fluoro-phenylhydrazone) 
• 55347-02-9 C₁₀H₉N₂OF 
• 620619-33-2 C₁₀H₅Cl₂FN₂O 
• 1416983-50-0 C₁₃H₁₃FN₂O₂S 
• 1281595-37-6 3-(3-fluorophenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid 
• 1322144-16-0 di-3-fluorophenyl selenide 
• 1057221-65-4 3-(3-fluorophenyl)quinoxalin-2(1H)-one 
• 1057224-08-4 3-(3-fluorophenyl)-1-methylquinoxalin-2(1H)-one 
• 105438-45-7 2-(3-Fluoro-phenyl)-5-methyl-2H-pyrazol-3-ylamine 

Relevant articles and documents

Fluorine-substituted phenyl pyrazole amide derivative, and preparation method and application thereof

The invention relates to a fluorine-substituted phenyl pyrazole amide derivative with insecticidal activity as shown in a general formula (I), and a preparation method and application thereof. On the basis of an existing phenyl pyrazole amide compound, fl

Preparation method for 3-fluorophenylhydrazine hydrochloride

The invention relates to a preparation method for 3-fluorophenylhydrazine hydrochloride. The preparation method comprises the following steps: diazotization, reduction, purification and salt formation. During diazotization and reduction, concentrated hydrochloric acid enables a reaction solution to maintain highly acidic, so smooth and complete reaction is guaranteed. In the step of reduction, zinc dust-concentrated hydrochloric acid is used as a reducing agent to replace sodium hyposulfite, sodium bisulfate, stannous chloride-hydrochloric acid, etc., and the zinc dust-concentrated hydrochloric acid is good in reducing property and high in yield, shortens reaction time, enables impurities like zinc hydroxide produced after the reaction to be easy to remove and allows produced 3-fluorophenylhydrazine hydrochloride to be low in impurity content and high in purity. In the step of salt formation, acetone is used for leaching, so product purity is improved and product appearance is guaranteed. The preparation method is stable and reliable in process and easy to operate; and produced 3-fluorophenylhydrazine hydrochloride is high in purity (no less than 99% according to the results of content measurement via high performance liquid chromatography), has a yield of no less than 39% and completely meets market demands for 3-fluorophenylhydrazine hydrochloride.

Synthesis and biological evaluation of 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives as potential c-met inhibitors

Six series of novel 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives conjugated with aza-aryl formamide/amine scaffords were designed and synthesized through a structure-based molecular hybridization approach. The target compounds were evaluated for c-Met kinase inhibitory activities and cytotoxicity against four cancer cell lines (HT-29, A549, MKN-45 and MDA-MB-231) in vitro. Most compounds exhibited moderate to excellent potency, and the most promising candidate 26c (c-Met kinase IC50 = 8.2 nM) showed a 4.7-fold increase in cytotoxicity against c-Met-addicted MKN-45 cell line in vitro (IC50 = 3 nM), superior to that of Foretinib (IC50 = 23 nM). The preliminary structure-activity relationship indicated that a 1H-benzo [e] [1,3,4]thiadiazine-3-carboxamide-4,4-dioxide moiety as linker contributed to the antitumor potency.