65880-17-3Relevant articles and documents
BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME
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, (2020/10/21)
The present disclosure relates to novel photoluminescent complexes comprising a BODIPY moiety covalently bonded to a blue light absorbing moiety, a color conversion film comprising the photoluminescent complex, and a back-light unit using the same.
Synthesis, Characterization, and Evaluation of Near-IR Boron Dipyrromethene Bioconjugates for Labeling of Adenocarcinomas by Selectively Targeting the Epidermal Growth Factor Receptor
Kaufman, Nichole E. M.,Meng, Qianli,Griffin, Kaitlin E.,Singh, Sitanshu S.,Dahal, Achyut,Zhou, Zehua,Fronczek, Frank R.,Mathis, J. Michael,Jois, Seetharama D.,Vicente, M. Gra?a H.
, p. 3323 - 3335 (2019/04/26)
A series of five boron dipyrromethene (BODIPY) bioconjugates containing an epidermal growth factor receptor (EGFR)-targeted pegylated LARLLT peptide and/or a glucose or biotin ethylene diamine group were synthesized, and the binding capability of the new conjugates to the extracellular domain of EGFR was investigated using molecular modeling, surface plasmon resonance, fluorescence microscopy, competitive binding assays, and animal studies. The BODIPY conjugates with a LARLLT peptide were found to bind specifically to EGFR, whereas those lacking the peptide bound weakly and nonspecifically. All BODIPY conjugates showed low cytotoxicity (IC50 > 94 μM) in HT-29 cells, both in the dark and upon light activation (1.5 J/cm2). Studies of nude mice bearing subcutaneous human HT-29 xenografts revealed that only BODIPY conjugates bearing the LARLLT peptide showed tumor localization 24 h after intravenous administration. The results of our studies demonstrate that BODIPY bioconjugates bearing the EGFR-targeting peptide 3PEG-LARLLT show promise as near-IR fluorescent imaging agents for colon cancers overexpressing EGFR.
HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS
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, (2017/12/17)
A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.
Benzoporphyrins: Selective Co-sensitization in Dye-Sensitized Solar Cells
Lodermeyer, Fabian,Costa, Rubén D.,Malig, Jenny,Jux, Norbert,Guldi, Dirk M.
supporting information, p. 7851 - 7855 (2016/06/09)
A novel class of dyes, namely benzoporphyrins, was synthesized and implemented into dye-sensitized solar cells. They feature complementary absorptions compared to N719, which renders them promising candidates for co-sensitization in DSSCs. Notably, metallated benzoporphyrins reveal a TiO2-nanoparticle attachment that is size and aggregation dependent. Therefore, unproductive energy-transfer events between the selectively attached dyes can be prevented. In light of the latter, an efficiency improvement of 39 % has been achieved upon selective adsorption of benzoporphyrins and N719 onto different layers of TiO2 photoelectrode.
TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES
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Page/Page column 18; 19; 29, (2016/11/17)
Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of t
Electrochemistry of nonplanar copper(II) tetrabutano- and tetrabenzotetraarylporphyrins in nonaqueous media
Ye, Lina,Ou, Zhongping,Fang, Yuanyuan,Xue, Songlin,Song, Yang,Wang, Liping,Wang, Mengli,Kadish, Karl M.
, p. 77088 - 77096 (2015/09/28)
Two series of copper tetraarylporphyrins containing β,β′-fused tetrabutano or tetrabenzo groups were synthesized and characterized as to their electrochemistry and spectroelectrochemistry in nonaqueous media. The examined compounds are represented as butano-(TpYPP)CuII and benzo-(TpYPP)CuII, where TpYPP is the porphyrin dianion and Y is a CH3, H or Cl substituent on the para-position of the four meso-phenyl rings of the compound. Each neutral porphyrin in the two series is ESR active and shows a typical d9 Cu(ii) signal in frozen CH2Cl2 solution. Each Cu(ii) porphyrin also undergoes two reversible one-electron reductions and two reversible one-electron oxidations in DMF or CH2Cl2 containing 0.1 M tetra-n-butylammonium perchlorate to give a π-anion radical and dianion upon reduction and a π-cation radical and dication upon oxidation. A third one-electron oxidation is also observed for butano-(TpYPP)Cu (Y = CH3 and H) and benzo-(TPP)Cu in PhCN and this process is assigned to the CuII/CuIII transition. The reversible half-wave potential for the first oxidation of each compound in both series is shifted negatively by about 500 mV as compared to E1/2 values for oxidation of the related copper tetraarylporphyrin without the four fused benzo or butano rings while smaller positive shifts of 60 and 300 mV are seen for reduction of the tetrabenzotetraarylporphyrins and tetrabutaotetraarylporphyrins, respectively, as compared to the same redox reactions of the related tetraarylporphyrins. The electrochemically measured HOMO-LUMO gap averages 1.76 ± 0.05 V for benzo-(TpYPP)CuII, 2.04 ± 0.06 V for butano-(TpYPP)CuII and 2.33 ± 0.03 for (TpYPP)Cu in CH2Cl2.
Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials
Kancharla, Papireddy,Kelly, Jane Xu,Reynolds, Kevin A.
, p. 7286 - 7309 (2015/10/05)
Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh
OXYGEN SENSORS
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Paragraph 0111, (2014/09/30)
Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
FUSED PYRROLE DERIVATES AS ESTROGEN RECEPTOR LIGANDS
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Page/Page column 51-51, (2012/10/18)
The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein Z, A, B, D,E, G, M1, M2, M3, M4, M5, M6, p, q, r, R3, R4, R5 and R6 are as defined in the specification. The invention also provides the use of such co
Manganese(III) complexes of bis(hydroxyphenyl)dipyrromethenes are potent orally active peroxynitrite scavengers
Rausaria, Smita,Kamadulski, Andrew,Rath, Nigam P.,Bryant, Leesa,Chen, Zhoumou,Salvemini, Daniela,Neumann, William L.
supporting information; experimental part, p. 4200 - 4203 (2011/06/21)
We report a new series of biscyclohexano-fused Mn(III) complexes of bis(hydroxyphenyl)dipyrromethenes, 4a-c, as potent and orally active peroxynitrite scavengers. Complexes 4a-c are shown to reduce peroxynitrite through a two-electron mechanism, thereby forming the corresponding Mn(V)O species, which were characterized by UV, NMR, and LC-MS methods. Mn(III) complex 4b and its strained BODIPY analogue 9b were analyzed by X-ray crystallography. Finally, complex 4a is shown to be an orally active and potent analgesic in a model carrageenan-induced hyperalgesia known to be driven by the overproduction of peroxynitrite.
