65915-94-8

Basic information

• Product Name: N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE
• Synonyms: N-T-BOC-1,6-DIAMINOHEXANE HCL;N-T-BOC-HEXAMETHYLENDIAMINE HCL;N-T-BUTYLOXYCARBONYL-1,6-HEXAMETHYLENEDIAMINE HYDROCHLORIDE;N-TERT-BUTOXYCARBONYL-1,6-HEXANEDIAMINE HYDROCHLORIDE;N-TERT-BUTYLOXYCARBONYL-1,6-HEXAMETHYLENEDIAMINE HYDROCHLORIDE;RARECHEM AR PA 0024;TIMTEC-BB SBB003133;TERT-BUTYL N-(6-AMINOHEXYL)CARBAMATE HYDROCHLORIDE
• CAS NO: 65915-94-8
• Molecular Formula: C₁₁H₂₄N₂O₂*ClH
• Molecular Weight: 252.78
• EINECS: 265-976-4
• Product Categories: Amino Acids
• Mol File: 65915-94-8.mol

Chemical Properties

• Melting Point: 162-164 °C(lit.)
• Boiling Point: 325.3 °C at 760 mmHg
• Flash Point: 150.5 °C
• Appearance: White to cream/Crystalline Powder
• Vapor Pressure: 0.000233mmHg at 25°C
• Storage Temp.: 2-8°C
• Sensitive: Hygroscopic
• BRN: 3631740
• CAS DataBase Reference: N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE(65915-94-8)
• EPA Substance Registry System: N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE(65915-94-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 65915-94-8(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE is used as a reagent for the introduction of a C6-spacer for the synthesis of poly(L-glutamic acid) gadolinium chelates. These chelates serve as biodegradable MRI contrast agents, enhancing the imaging capabilities in medical diagnostics.
2. Used in Biomedical Applications:
N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE is used as a reagent for the synthesis of cholesteryl-functionalized hyaluronic acid-based anionic nanogel. This nanogel is employed for protein delivery, offering a targeted and efficient method for therapeutic agents to reach their intended sites in the body.
3. Used in Drug Delivery Systems:
N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE is used as a reagent in the preparation of amphiphilic prodrugs. These prodrugs contain the anticancer drug chlorambucil and have the ability to self-assemble into micelles in aqueous solutions. This self-assembly property enhances the drug's solubility, bioavailability, and targeted delivery to cancer cells, potentially improving treatment outcomes.
4. Used in Chemical Synthesis:
N-BOC-1,6-DIAMINO-HEXANE HYDROCHLORIDE is used as a general reagent to introduce a C6-spacer in various chemical synthesis processes. This spacer can be utilized to create a variety of compounds with specific properties and applications in different industries, such as pharmaceuticals, materials science, and biotechnology.

InChI:InChI=1/C11H24N2O2.ClH/c1-11(2,3)15-10(14)13-9-7-5-4-6-8-12;/h4-9,12H2,1-3H3,(H,13,14);1H

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 4048-33-3 6-amino-1-hexanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75937-12-1 6-(Boc-amino)-1-hexanol 
• 58-85-5 biotin 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 75950-19-5 tert-butyl [6-[(methylsulphonyl)oxy]hexyl]carbamate 
• 129392-87-6 1-Azido-6-(tert-butoxycarbonylamino)hexane 
• 51857-17-1 tert-butyl N-(6-aminohexyl)carbamate 

Downstream Products

• 145118-28-1 N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine 
• 145118-12-3 N--L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine 
• 366820-50-0 [6-(5-chloro-2-nitro-benzyloxycarbonylamino)-hexyl]-carbamic acid tert-butyl ester 
• 153162-70-0 tert-butyl (6-(5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl)carbamate 
• 34995-01-2 N-(6-aminohexyl)-5-dimethylamino-naphthalene-1-sulfonamide 
• 626255-45-6 (E,E)-N-{4-{4-(4-methyl-2,5-bis[(S)-2-methylbutoxy]styryl)-2,5-bis[(S)-2-methylbutoxy]styryl}-2,5-bis[(S)-2-methylbutoxy]benzoyl}hexyldiamine 
• 626255-47-8 (E,E)-6-{4-{4-(4-methyl-2,5-bis[(S)-2-methylbutoxy]styryl)-2,5-bis[(S)-2-methylbutoxy]styryl}-2,5-bis[(S)-2-methylbutoxy]benzoylamino}hexylureidoacetic acid ethyl ester 
• 626255-50-3 (E,E)-3-[6-{4-{4-(4-methyl-2,5-bis[(S)-2-methylbutoxy]styryl)-2,5-bis[(S)-2-methylbutoxy]styryl}-2,5-bis[(S)-2-methylbutoxy]benzoylamino}hexylureido]propionic acid ethyl ester 
• 65953-56-2 N-(6-aminohexyl)-5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d] imidazol-4-yl)pentanamide 
• 277327-89-6 tert-butyl 3-(((6-((tert-butoxy)carbonylamino)hexyl)amino)methyl)-4-fluorobenzoate 

Relevant articles and documents

Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide

Disclosed are biological reagents which comprise compounds that inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of β-amyloid peptide.

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Nα-tert-Butoxycarbonyl α,ω-alkanediamine hydrochlorides 3a-e are prepared from the amino alcohols in yields of 66-87percent.Reaction of the free amine with di-tert-butyl dicarbonate gives the N-tert-Butoxycarbonylamino alcohol 1a-e.One-pot conversion to the azide 2a-e via the mesylate under phase-transfer conditions followed by hydrogenolysis in the presence of chloroform yields the title compounds.

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