6659-34-3

Basic information

• Product Name: 1-methyl-4-piperidyl acetate
• Synonyms: 1-methyl-4-piperidyl acetate;N-Methylpiperidin-4-yl [1-13C]acetate
• CAS NO: 6659-34-3
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.21
• Mol File: 6659-34-3.mol

Chemical Properties

• Boiling Point: 190 °C at 760 mmHg
• Flash Point: 68 °C
• Appearance: /
• Density: 1.02 g/cm³
• Vapor Pressure: 0.553mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: 1-methyl-4-piperidyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-piperidyl acetate(6659-34-3)
• EPA Substance Registry System: 1-methyl-4-piperidyl acetate(6659-34-3)

Safety Data

• Hazardous Substances Data: 6659-34-3(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
1-methyl-4-piperidyl acetate is used as a flavoring agent for its pleasant odor, enhancing the taste and aroma of food products.
1-methyl-4-piperidyl acetate is used as a fragrance ingredient in perfumes, soaps, and cosmetics, contributing to their pleasant scent.
Used in Pharmaceutical Industry:
1-methyl-4-piperidyl acetate is used as an intermediate in the synthesis of various medications, playing a crucial role in the development of new drugs.
Used in Insecticides and Repellents:
1-methyl-4-piperidyl acetate is used as an insect-repellent, providing protection against insects and pests due to its natural repelling properties.
Safety:
1-methyl-4-piperidyl acetate is considered relatively safe for use in these applications, with low potential for toxicity or adverse health effects, making it a preferred choice in various industries.

InChI:InChI=1/C8H15NO2/c1-7(10)11-8-3-5-9(2)6-4-8/h8H,3-6H2,1-2H3

Upstream product

• 106-52-5 N-methyl-4-hydroxypiperidine 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Synthesis, antimuscarinic activity and quantitative structure-activity relationship (QSAR) of tropinyl and piperidinyl esters

A series of tropinyl and piperidinyl esters was synthesized and evaluated for inhibitory activities on the endothelial muscarinic receptors of rat (M3) and rabbit (M2) aorta. Some of the esters (cyclohexylphenylglycolates and cyclohexylphenylpropionates) were found to be better antimuscarinic compounds than standard M2 and M3 inhibitors such as AFDX116 and 4-diphenylacetoxy-N-methylpiperidine (DAMP), with pKEC50 values in the range of 8-9. A few esters were found to be more selective M3 than M2 inhibitors, but these tended to have low activities. The hydrophobic, electronic and steric characteristics of these esters were correlated with antimuscarinic activity by using appropriate parameters representing hydrophobicity (HPLC capacity factor, log k(w), size (molecular volume) and electronic character (Taft's polar substituent constant δ and 13C chemical shift difference Δδ). Finally, 92% of the M2-inhibitory activities of the esters could be accounted for by the size and electronic character σ* of the side chain. In contrast, the M3-inhibitory activities of these esters were mainly attributed to the electronic nature (σ*, Δδ) of the side chain, with good activity being associated with electron-withdrawing groups. Visualization of the comparative molecular field analysis (CoMFA) steric and electrostatic fields provided further confirmation of the structure-activity relationship (SAR) derived from traditional quantitative structure-activity relationship (QSAR) approaches.