66937-94-8

Basic information

• Product Name: C₁₄H₁₉NO₂
• CAS NO: 66937-94-8
• Molecular Weight: 233.31
• Mol File: 66937-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₉NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₉NO₂(66937-94-8)
• EPA Substance Registry System: C₁₄H₁₉NO₂(66937-94-8)

Safety Data

• Hazardous Substances Data: 66937-94-8(Hazardous Substances Data)

Upstream product

• 339183-92-5 C₁₉H₂₇NO₄ 
• 123387-50-8 4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.