67341-33-7

Basic information

• Product Name: Benzene, 1,3-dichloro-2-methoxy-5-methyl-
• CAS NO: 67341-33-7
• Molecular Formula: C8H8Cl2O
• Molecular Weight: 191.057
• Mol File: 67341-33-7.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dichloro-2-methoxy-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dichloro-2-methoxy-5-methyl-(67341-33-7)
• EPA Substance Registry System: Benzene, 1,3-dichloro-2-methoxy-5-methyl-(67341-33-7)

Safety Data

• Hazardous Substances Data: 67341-33-7(Hazardous Substances Data)

Upstream product

• 2432-12-4 2,6-dichloro-4-methylophenol 
• 74-88-4 methyl iodide 
• 104-93-8 p-methylanizole 

Downstream Products

• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 3337-59-5 methyl 3,5-dichloro-4-hydroxybenzoate 
• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 
• 98544-66-2 4-bromomethyl-2,6-dichloro-anisole 
• 103347-14-4 4-(bromomethyl)-1-chloro-2-methoxybenzene 
• 169045-07-2 2-{[4-chloro-3-(methyloxy)phenyl]methyl}-1H-isoindole-1,3(2H)-dione 
• 247570-29-2 N-(3,5-dichloro-4-methoxybenzyl)phthalimide 
• 247570-14-5 5-bromo-N-(4-chloro-3-methoxybenzyl)-2-fluorobenzamide 
• 247570-15-6 N-(4-chloro-3-methoxybenzyl)-2-fluoro-5-vinylbenzamide 
• 247569-43-3 N-(4-chloro-3-methoxybenzyl)-2-fluoro-5-nitrobenzamide 
• 247567-34-6 N-Benzyl-2-[2-hydroxy-1-(hydroxymethyl)ethylamino]-5-nitrobenzamide 
• 247568-34-9 2-fluoro-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247570-16-7 5-acetyl-2-fluoro-N-(4-chloro-3-methoxybenzyl)benzamide 
• 247569-57-9 N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide 

Relevant articles and documents

A simple, efficient and regioselective oxychlorination of aromatic compounds using ammonium chloride and oxone

A simple, efficient, mild and regioselective method for oxychlorination of aromatic compounds is reported. The electrophilic substitution of chlorine generated in situ from NH4Cl as a chlorine source and oxone as an oxidant is reported for the first time.

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.

Formation of Nonaromatic Products in the Chlorination of Simple Substituted Aromatic Ethers

The neat chlorination of 4-chloroanisole produces 1,3,4,5,6-pentachloro-4-methoxycyclohexene in 35percent yield.Mono- and dichlorinated anisoles and a variety of simple substituted anisoles were chlorinated to determine the generality of nonaromatic product formation. 3,4-Dichloroanisole, 4-fluoroanisole, 4-bromoanisole, 4-methylanisole, and 4-chlorophenetole form similar products based on their spectral properties.These products are proposed to form by a cis-1,2-chlorine addition followed by rapid cis-1,4 chlorine addition.On the basis of the NMR data, a predominate configuration is proposed.

Solvent and Acidity Effects in Chlorination of p-Methoxytoluene by Chloramine-T

Kinetics of chlorination of p-methoxytoluene by chloramine-T (CAT) in aqueous acetic acid-perchloric acid medium is found to be zero order in and first order in .The acidity profile is curiously solvent dependent.The activation parameters in 50percent (v/v) aqueous acetic acid and at 60 deg C are ΔE(excit.) = 63.69 kJ mol-1, ΔH(excit.) = 60.94 kJ mol-1, log10A = 6.66 and ΔS(excit.) = -126.6 JK-1 mol-1.A plausible mechanism is suggested.