6832-16-2

Basic information

• Product Name: METHYL DIAZOACETATE
• Synonyms: METHYL DIAZOACETATE;Diazo Methyl acetate;methyl 2-diazoacetate;2-diazonio-1-methoxyethenolate
• CAS NO: 6832-16-2
• Molecular Formula: C₃H₄N₂O₂
• Molecular Weight: 100.07606
• Mol File: 6832-16-2.mol

Chemical Properties

• Boiling Point: 187.47°C (rough estimate)
• Appearance: /
• Density: 1.4457 (rough estimate)
• Refractive Index: 1.5110 (estimate)
• CAS DataBase Reference: METHYL DIAZOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL DIAZOACETATE(6832-16-2)
• EPA Substance Registry System: METHYL DIAZOACETATE(6832-16-2)

Safety Data

• Hazardous Substances Data: 6832-16-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl diazoacetate is used as a key intermediate in the synthesis of various pharmaceuticals, leveraging its ability to participate in critical chemical reactions that facilitate the creation of new drug molecules.
Used in Agrochemical Production:
In the agrochemical industry, Methyl diazoacetate serves as an essential reagent for the production of different agrochemicals, contributing to the development of substances that aid in crop protection and enhancement of agricultural yields.
Used in Organic Chemistry Research:
Due to its versatility in carrying out important chemical reactions, Methyl diazoacetate is utilized in organic chemistry research to explore new synthetic pathways and develop innovative methods for the formation of complex organic molecules.

InChI:InChI=1S/C3H4N2O2/c1-7-3(6)2-5-4/h2H,1H3

Upstream product

• 861350-38-1 2-diazo-3-oxo-5-phenyl-pent-4-enoic acid methyl ester 
• 124-41-4 sodium methylate 
• 95205-34-8 dinitrosated benzoylglycylglycine methyl ester 
• 102818-48-4 (1,3-Diphenylimidazolidin-2-yl)-diazoessigsaeure-methylester 
• 1807-69-8 2-diazo-3-oxo-3-phenyl-propionic acid methyl ester 

Downstream Products

• 98272-73-2 (+/-)-trans-2-acetoxy-cyclopropanecarboxylic acid methyl ester 
• 10036-65-4 4-phenyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester 
• 4077-76-3 3,5-dicarbomethoxypyrazole 
• 20618-07-9 methyl 2,3,3-trichloropropanoate 
• 96-34-4 methyl chloroacetate 
• 102540-99-8 (+/-)-trans-2-tert-butoxy-cyclopropanecarboxylic acid methyl ester 
• 3112-31-0 3,5-pyrazoledicarboxylic acid 
• 21483-46-5 dimethyl 3-methylbenzene-1,2-dicarboxylate 
• 17649-59-1 dimethyl 4,5-dimethylphthalate 
• 41046-64-4 dimethyl 3,4-dimethylphthalate 
• 1807-69-8 2-diazo-3-oxo-3-phenyl-propionic acid methyl ester 
• 2723-38-8 cyclopentylacetic acid methyl ester 
• 14352-61-5 methyl cyclohexylacetate 
• 20116-65-8 dimethyl 4-methylphthalate 

Relevant articles and documents

INVESTIGATION OF THE STAUDINGER REACTION BETWEEN BICYCLIC PHOSPHITE AND DIAZO COMPOUNDS

Nine bicyclic phosphatazines were synthesized by the Staudinger reaction between bicyclic phosphite (1) and diazo compounds (2-5), the Elemental Analysis data, IR, 31P NMR and Mass Spectral data of these compounds are reported.The reaction of diazoacetate with bicyclic phosphite was followed by 31P NMR, the concentration-time curve was simulated by Optimal Approximation with a computer.It was found that this reaction consisted of two steps, the first step was second-order and the second was first-order.A possible mechanism is also proposed.Key words: Staudingerreaction; bicyclic phosphite; phosphatazine; optimal approximation; NMR; IR.

DIAZOVERBINDUNGEN-67. ELEKTROPHILE DIAZOALKANSUBSTITUTION MIT DONORSUBSTITUIERTEN KATIONEN

The imidazolinium chloride 8 reacts with diazomethyl compounds 3 (in the presence of an amine) or with metal derivatives of 3 under the formation of the 2-(diazomethyl)imidazolidines 2.Compounds of the same type are received by treatment of the electron-r

NITROSATION OF PEPTIDE BONDS. CLEAVAGE OF NITROSATED PEPTIDES BY PYRROLIDINE AND α-AMINO ESTERS

The reaction of several α-amino acids and peptides (containing Gly, L-Ala, L-Leu, L- or DL-Phe, and/or L- or D-Val) with air-diluted nitrogen oxides has been studied to roughly mimic the N-nitrosation of peptide bonds that the contaminated urban air might produce in pulmonary tissues. Most N-protected α-amino acids give practically quantitative yields of N-nitroso derivatives. N-Protected dipeptides afford either dinitrosated peptides, mixtures of di- and mononitrosated compounds, selectively mononitrosated products, or no reaction at all, depending mainly on steric effects. The same trends are observed for some higher peptides.The (poly)nitrosated peptides, which retain the chirality of the starting materials, have been characterized by 1H and 13C NMR spectroscopy and are cleaved by pyrrolidine and amino esters under mild conditions to give (new) amides or peptides plus diazo derivatives.