68981-86-2

Basic information

• Product Name: 4,5-DIHYDRO-4,4-DIMETHYL-2-(3-PYRIDYL)OXAZOLE
• Synonyms: 4,5-DIHYDRO-4,4-DIMETHYL-2-(3-PYRIDYL)OXAZOLE;3-(4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL)PYRIDINE;4,5-Dihydro-4,4-dimethyl-2-(pyrid-3-yl)oxazole;4,5-DIHYDRO-4,4-DIMETHYL-2-(3-PYRIDYL)OX;PYRIDINE,3-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL);3-(4,4-DiMethyl-2-oxazolinyl)pyridine, 97%;3-(4,5-Dihydro-4,4-dimethyl-1,3-oxazol-2-yl)pyridine;4,5-Dihydro-4,4-dimethyl-2-(pyridin-3-yl)-1,3-oxazole
• CAS NO: 68981-86-2
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Product Categories: Oxazole&Isoxazole
• Mol File: 68981-86-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 25-27℃
• Boiling Point: 284.7 ºC at 760 mmHg
• Flash Point: 126 ºC
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.00504mmHg at 25°C
• Refractive Index: 1.569
• PKA: 4.13±0.12(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4,5-DIHYDRO-4,4-DIMETHYL-2-(3-PYRIDYL)OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIHYDRO-4,4-DIMETHYL-2-(3-PYRIDYL)OXAZOLE(68981-86-2)
• EPA Substance Registry System: 4,5-DIHYDRO-4,4-DIMETHYL-2-(3-PYRIDYL)OXAZOLE(68981-86-2)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 68981-86-2(Hazardous Substances Data)

Usage

General Description

4,5-Dihydro-4,4-dimethyl-2-(3-pyridyl)oxazole is a chemical compound with the molecular formula C11H13NO. It is a heterocyclic organic compound with a five-membered ring containing nitrogen and oxygen atoms. This chemical is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals, where it acts as a key intermediate in the production of biologically active compounds. Additionally, it is also used in research and development in the fields of medicinal chemistry and drug discovery. The compound's structure and properties make it valuable for the creation of molecules with potential therapeutic applications.

InChI:InChI=1/C10H12N2O/c1-10(2)7-13-9(12-10)8-4-3-5-11-6-8/h3-6H,7H2,1-2H3

Upstream product

• 626-55-1 3-Bromopyridine 
• 30093-99-3 4,4-dimethyl-2-oxazoline 
• 129665-83-4 Li(4,4-dimethyl-2-oxazolinyl) 
• 68981-81-7 3-(4,4-dimethyloxazolin-2-yl)-4-t-butyl-1,4-dihydropyridine 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 100-54-9 pyridine-3-carbonitrile 
• 59-67-6 nicotinic acid 
• 93-60-7 methyl 3-pyridinecarboxylate 

Downstream Products

• 68981-85-1 3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)-4-phenylpyridine 
• 87902-89-4 2-phenyl-5-(4,4-dimethyl-3-oxazolinyl)pyridine 
• 155136-54-2 4-methylnicotinoyl chloride 
• 94015-05-1 4-methylpyridine-3-carboxylic acid hydrochloride 
• 111737-55-4 3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-4-((S)-2-methyl-butyl)-1-((R)-1-phenyl-ethyl)-1,4-dihydro-pyridine 
• 111737-55-4 3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-4-((S)-2-methyl-butyl)-1-((S)-1-phenyl-ethyl)-1,4-dihydro-pyridine 
• 68981-84-0 3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)-4-methylpyridine 
• 87902-91-8 3-(4,4-dimethyloxazolin-2-yl)-4-(2-methoxy-3-hydroxyphenyl)pyridine 
• 87903-07-9 4-(3-Methoxy-2-methoxycarbonylmethoxy-phenyl)-nicotinic acid tert-butyl ester 
• 87903-08-0 4-(2-Ethoxycarbonylmethoxy-3-methoxy-phenyl)-nicotinic acid tert-butyl ester 
• 87921-95-7 4-(2-Isopropoxycarbonylmethoxy-3-methoxy-phenyl)-nicotinic acid tert-butyl ester 
• 87903-10-4 4-(3-Methoxy-2-methoxycarbonylmethoxy-phenyl)-nicotinic acid 1,1-diethyl-propyl ester 
• 87902-96-3 3-<(3-ethyl-3-pentoxy)carbonyl>-4-<2-<(ethoxycarbonyl)methoxy>-3-methoxyphenyl>pyridine 
• 87903-09-1 4-(2-Isobutoxycarbonylmethoxy-3-methoxy-phenyl)-nicotinic acid 1,1-diethyl-propyl ester 

Relevant articles and documents

Secondary Phosphine Oxide Preligands for Palladium-Catalyzed C–H (Hetero)Arylations: Efficient Access to Pybox Ligands

C–H arylations of oxazolines were accomplished with a well-defined palladium catalyst derived from a secondary bisdiamantyl phosphine oxide. The single-component secondary phosphine oxide (SPO)-palladium complex enabled C–H activations with aryl bromides

Direct synthesis of 2-oxazolines from carboxylic acids using 2-chloro-4,6-dimethoxy-1,3,5-triazine under mild conditions

2-Acyloxy-4,6-dimethoxy-1,3,5-triazines obtained from carboxylic acids and 2-chloro-4,6-dimethoxy-1,3,5-triazine were subsequently treated with 2-amino-2-methyl-1-propanol to afford the corresponding 2-oxazolines in excellent yield at room temperature.

The direct synthesis of 2-Oxazolines from carboxylic esters using lanthanide chloride as catalyst

Using catalytic amounts of lanthanide III (Ln = La, Sm) chlorides and amino alkoxides as reagents, an one-pot direct synthesis for 2-oxazolines, in good yield, from carboxylic esters has been developed.