70-53-1

Basic information

• Product Name: DL-Lysine monohydrochloride
• Synonyms: DL-Lysine monohydrochloride,DL-2,6-Diaminohexanoic acid monohydrochloride;DL-Lysine Monohydrochloride, 99% 25GR;DL-Lys·HCl;(R,S)-2,6-Diaminohexanoic acid monohydrochloride;DL-Lysine hydrochloride≥ 99% (Titration);H-DL-LYS-OH HCL;DL-2,6-DIAMINOHEXANOIC ACID HYDROCHLORIDE;DL-2,6-DIAMINOHEXANOIC ACID MONOHYDROCHLORIDE
• CAS NO: 70-53-1
• Molecular Formula: C₆H₁₄N₂O₂*ClH
• Molecular Weight: 182.65
• EINECS: 200-739-0
• Product Categories: amino acid;Lysine [Lys, K];alpha-Amino Acids;Amino Acids;Biochemistry
• Mol File: 70-53-1.mol

Chemical Properties

• Melting Point: 267 °C (dec.)(lit.)
• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 142.2 °C
• Appearance: White/Powder, Granules or Chunks
• Density: 1.125 g/cm3
• Vapor Pressure: 0.000123mmHg at 25°C
• Storage Temp.: Store at RT.
• Solubility: H2O: soluble
• Water Solubility: Soluble in water. Insoluble in ethanol, ethyl ether, acetone, benzene and common neutral solvents.
• Stability: Stable. Incompatible with strong oxidizing agents.
• BRN: 4711993
• CAS DataBase Reference: DL-Lysine monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Lysine monohydrochloride(70-53-1)
• EPA Substance Registry System: DL-Lysine monohydrochloride(70-53-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 70-53-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
DL-Lysine monohydrochloride is used as an intermediate in the preparation of 3-amino-azepan-2-one, which is a compound with potential pharmaceutical applications.
Used in Animal Feed Industry:
DL-Lysine monohydrochloride is used as an essential amino acid in animal feed, promoting the growth and development of livestock and improving their overall health.
Used in Biotechnology Industry:
DL-Lysine monohydrochloride is used in the construction of polylysine polymers, which are biodegradable and biocompatible materials with applications in lysine-based polypeptide gels and films. These materials have potential uses in drug delivery, tissue engineering, and other biomedical applications.

InChI:InChI=1/2C6H14N2O2.2ClH/c2*7-4-2-1-3-5(8)6(9)10;;/h2*5H,1-4,7-8H2,(H,9,10);2*1H/t2*5-;;/m10../s1

Upstream product

• 56-87-1 L-lysine 
• 6804-88-2 α-nitrocaprolactam 
• 70-53-1 2,6-Diamino-hexanoic acid; hydrochloride 
• 923-27-3 D-lysine 

Downstream Products

• 6416-98-4 N^α-Formyl-N^ε-benzyloxycarbonyl-lys 
• 212185-11-0 N^ε-Tosyl-lysin 
• 97326-98-2 C₂₉H₂₅N₂O₉S₂^(3-)*3Na⁽¹⁺⁾ 
• 17929-90-7 3-aminoazepan-2-one 
• 2483-46-7 2,6-bis-tert-butoxycarbonylamino-hexanoic acid 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 1190-48-3 N^ε-formyl-(2S)-lysine 
• 16011-35-1 N-benzylidene-L-lysine 
• 13515-95-2 lysine methyl ester dihydrochloride 
• 23735-91-3 ε-acetyllysine methyl ester hydrochloride 
• 118812-46-7 DPAB-D-Lys (trans) 
• 70-53-1 2,6-Diamino-hexanoic acid; hydrochloride 

Relevant articles and documents

Rational synthesis of all the four stereoisomers of 3-(trans-2- aminocyclopropyl)alanine

All the four stereoisomers of 3-(trans-2-aminocyclopropyl)alanine - a key constituent of the potential antitumor agent belactosin A -were prepared by simple catalytic hydrogenation of (2S,1′S,2′S)-, (2S,1′R,2′R)-, (2R,1′R,2′R)-, and (2R,1′S, 2′S)-3-(trans-2-nitro-cyclopropyl)alanines in 95, 93, 91 and 92% yields, respectively.

Chiral Receptors for Lysine Based on Covalently Linked Bis- and Tris-binaphthylphosphoric Acids

The synthesis and application of three chiral receptors based on the covalent linkage of 1,1′-binaphthylphosphoric acids is reported. The binding of the lysine enantiomers to the chiral receptors was investigated by DOSY-NMR and NMR titrations, revealing that the bisphosphoric acid 1d acts as a highly stereoselective receptor for binding of d-lysine.

Process for racemizing optically active α-amino acids or a salt thereof

DL-α-amino acids or a salt thereof can be obtained by racemizing an optically active α-amino acid or a salt thereof in the presence of an aliphatic acid and an aldehyde.

Method for the Racemization of Optically Active Amino Acids

A practical method for the racemization of optically active amino acids has been developed.A wide variety of optically active α-amino acids, including neutral amino acids, acidic amino acids, basic amino acids, and imino acids, could be racemized by heating in a medium of acetic acid at 80-100 deg C for 1 h in the presence of 0.05 molar equiv of an aliphatic or an aromatic aldehyde.The factors influencing the racemization were investigated.Phenylglycine, (p-hydroxyphenyl)glycine, and serine could be racemized without complete dissolution of the optically active isomers.Thus, isolation of the racemic modification was easily achieved by simple filtration of the racemic modification suspended in the reaction mixture.The mechanism of the racemization is discussed.