70-57-5

Basic information

• Product Name: 5-METHYLNICOTINAMIDE
• Synonyms: 5-METHYLPYRIDINE-3-CARBOXAMIDE;5-METHYLNICOTINAMIDE;3-Pyridinecarboxamide,5-methyl-(9CI);5-Methyl-3-PyridinecarboxaMide
• CAS NO: 70-57-5
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• EINECS: -0
• Product Categories: AMIDE;Pyridines
• Mol File: 70-57-5.mol

Chemical Properties

• Melting Point: 166-168°C
• Boiling Point: 290 °C at 760 mmHg
• Flash Point: 129.2 °C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 0.00213mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• BRN: 4962976
• CAS DataBase Reference: 5-METHYLNICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYLNICOTINAMIDE(70-57-5)
• EPA Substance Registry System: 5-METHYLNICOTINAMIDE(70-57-5)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 70-57-5(Hazardous Substances Data)

Usage

Uses

5-Methylnicotinamide can be used to treat necrotizing enterocolitis.

InChI:InChI=1/C7H8N2O/c1-5-2-6(7(8)10)4-9-3-5/h2-4H,1H3,(H2,8,10)

Upstream product

• 591-22-0 3,5-Lutidine 
• 3222-49-9 5-methylnicotinic acid 
• 20826-02-2 ethyl 5-methyl-3-pyridinecarboxylate 
• 884494-95-5 5-methyl-nicotinic acid chloride 

Downstream Products

• 3430-19-1 5-methylpyridin-3-amine 
• 445041-06-5 C₂₆H₂₃Cl₂N₂O₆⁽¹⁺⁾ 
• 114995-63-0 (2-Amino-3,5-difluoro-phenyl)-(5-fluoro-pyridin-3-yl)-methanone 
• 22620-32-2 (5-fluoropyridin-3-yl)methanol 
• 39891-04-8 5-fluoropyridine-3-carboxaldehyde 
• 455-70-9 5-fluoro-3-pyridinecarboxylic acid methyl ester 
• 177660-92-3 4-[2-(5-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-1-yl]benzenesulfonamide 
• 177660-88-7 3-methyl-5-[1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazol-2-yl]pyridine 
• 42885-14-3 5-cyano-3-methylpyridine 

Relevant articles and documents

COMPOUNDS AND USE THEREOF IN THE EXPANSION OF STEM CELLS AND/OR PROGENITOR CELLS

The invention relates to compounds of formula I and pharmaceutical compositions containing them. Also, the invention relates to methods for expanding stem cells and/or progenitor cells and methods for treating a hematopoietic disorder/malignancy, and autoimmune disease and/or an inherited immunodeficient disease (I).

Manganese oxide promoted liquid-phase aerobic oxidative amidation of methylarenes to monoamides using ammonia surrogates

In the presence of amorphous MnO2, various methylarenes (even with two or more methyl groups) could be selectively converted into the corresponding primary monoamides in moderate to high yields. The observed catalysis was truly heterogeneous, and the retrieved amorphous MnO2 catalyst could be reused without an appreciable loss of its catalytic performance. Copyright

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

A process for the preparation of 4-[2-(aryl or heterocyclo)-1H-imidazol-1-yl]benzenesulfonamides

A process to make a compound of the formula or a pharmaceutically acceptable salt thereof is disclosed wherein R3 is a radical selected from hydrido, alkyl, haloalkyl, aralkyl, heterocycloalkyl, heteroaralkyl, acyl, cyano, alkaxy, alkylthio, alkylthioalkyl, alkylsulfonyl, cycloalkylthio, cycloalkylthioalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl, haloalkylsulfonyl, arylsulfonyl, halo, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclocarbonyl, cyanoalkyl, aminoalkyl, alkylaminoalkyl, N-arylaminoalkyl, N-alkyl-N-arylaminoalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, haloalkylcarbonyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, alkylaminocarbonylalkyl, heteroarylalkoxyalkyl, heteroaryloxyalkyl, heteroarylthioalkyl, aralkoxy, aralkylthio, heteroaralkoxy, heteroaralkylthio, heteroarylalkylthioalkyl, heteroaryloxy, heteroarylthio, arylthioalkyl, aryloxyalkyl, arylthio, aryloxy, aralkylthioalkyl, aralkoxyalkyl, aryl and heteroaryl; wherein R4 is a radical selected from hydrido, alkyl and halo; and wherein R2 is selected from aryl and heterocyclo, wherein R2 is optionally substituted at a substitutable position with one or more radicals independently selected from alkylsulfonyl, aminosulfonyl, halo, alkylthio, alkyl, cyano, carboxyl, alkoxycarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkoxy, amino, alkylamino, arylamino and nitro; ???said method comprising the steps of forming a (protected sulfonyl)benzenamine, treating said (protected sulfonyl)benzenamine first with a base and then with a nitrile to form an amidine, treating said amidine with a haloketone derivative in the presence of a base to form a hydroxyimidazole, forming a (protected sulfonylphenyl) imidazole by dehydrating said hydroxyimidazole, and forming said compounds by deprotecting said (protected sulfonylphenyl)imidazole.

1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation

A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: STR1 wherein R1 -R6 are as described in the specification; or a pharmaceutically-acceptable salt thereof.

A General Synthesis of Substituted Fluorenones and Azafluorenones

Twenty-one variously substituted fluorenones and azafluorenones have been synthesized via photochemical Pschorr cyclizations of 2-diazoniodiaryl ketones as the key ring-forming step.Direct, (bipy)3RuII-, or (bipy)3RuII/CuII-photosensitized conditions were used, depending on the system to be cyclized.Where selectivities were possible in the ring closure, the isomer ratios obtained were in accord with an aryl radical as the reactive intermediate.The precursor aminodiaryl ketones were obtained from the sequence ortho lithiation of an arylpivalamide, reaction withan aryl aldehyde to give a 2-pivalamidodiarylcarbinol, oxidation to give a 2-pivalamidodiaryl ketone, and hydrolysis to give the 2-aminodiaryl ketone.

NMR Properties and Synthesis of Ring-methylated 1,4-Dihydronicotinamides and the Corresponding Pyridinium Salts. Correlation of NMR with Ab Initio STO-3G Results

The synthesis of a series of ring-methylated 1-alkyl-1,4-dihydronicotinamides and the corresponding pyridinium salts is described.Their NMR properties involving aromatic-ring-shielding anisotropy, due to ring current effects, are discussed and compared with electron populations calculated from STO-3G results.