3430-19-1

Basic information

• Product Name: 5-Methylpyridin-3-amine
• Synonyms: 3-AMINO-5-PICOLINE;3-AMINO-5-METHYLPYRIDINE;5-METHYL-PYRIDIN-3-YLAMINE;3-Amino-5-methylpyridine97%;3-Pyridinamine,5-methyl-(9CI);5-methyl-3-pyridylamine hydrochloride salt;5-Methyl-3-pyridinamine;5-Amino-3-methylpyridine
• CAS NO: 3430-19-1
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• EINECS: 1806241-263-5
• Product Categories: VARIOUSAMINE;Heterocyclic Compounds;Amino;Intermediate;Pyridine;Boronic Acid;C6;Heterocyclic Building Blocks;Pyridines;Building Blocks;Pyridine Series;Heterocycle-Pyridine series
• Mol File: 3430-19-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 59-63°C
• Boiling Point: 153°C
• Flash Point: 135.6 °C
• Appearance: /
• Density: 1.068 g/cm³
• Vapor Pressure: 0.0118mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 6.46±0.20(Predicted)
• CAS DataBase Reference: 5-Methylpyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylpyridin-3-amine(3430-19-1)
• EPA Substance Registry System: 5-Methylpyridin-3-amine(3430-19-1)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 22-37/38-41-20/21/22
• Safety Statements: 26-36/37/39-36
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT, TOXIC
• PackingGroup: III
• Hazardous Substances Data: 3430-19-1(Hazardous Substances Data)

Usage

Uses

3-Amino-5-methylpyridine is an important intermediate in organic synthesis, mainly used in pharmaceutical intermediates, organic synthesis, organic solvents, and can also be used in the production of dyes, pesticides and spices.

Synthesis

3-Amino-5-methylpyridine can be obtained by condensation reaction and decarboxylation reaction of diethyl malonate, sodium, 3-nitro-5-chloropyridine, and then reduction reaction.

InChI:InChI=1/C6H8N2/c1-5-2-6(7)4-8-3-5/h2-4H,7H2,1H3

Synthetic route

5-methylpyridinylcarboxamide (70-57-5) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With potassium hydroxide; bromine 1.) RT, 1 h, 2.) 70 deg C, 15 min;	67%
With sodium hydroxide; bromine In tetrahydrofuran at 5 - 70℃; Hoffmann rearrangement;

2-amino-3-methyl-5-nitropyridine (18344-51-9) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With hydrazine In water at 110 - 120℃; for 5h;	45%
Multi-step reaction with 3 steps 1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: phosphoryl chloride 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme

5-Methyl-3-nitro-2-aminopyridine (7598-26-7) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With hydrazine In water at 110 - 120℃; for 5h;	41%

2-chloro-3-methyl-5-nitropyridine (22280-56-4) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With palladium on activated charcoal; sodium acetate; acetic acid Hydrogenation;

3,5-Lutidine (591-22-0) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
Multi-step reaction with 4 steps 1: 27 percent / potassium permanganate / H2O / 1.) from RT to 43 deg C, 5 h, 2.) 45 deg C, overnight 2: thionyl chloride / Heating 3: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 4: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme

5-methylnicotinic acid (3222-49-9) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / Heating 2: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 3: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme

5-methyl-nicotinic acid chloride (884494-95-5) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 2: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme

3-methylpyridin-2-ylamine (1603-40-3) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
Multi-step reaction with 4 steps 1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: phosphoryl chloride 4: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme
Multi-step reaction with 3 steps 1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme

2-hydroxy-3-methyl-5-nitropyridine (21901-34-8) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphoryl chloride 2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme

2-bromo-3-methyl-5-nitropyridine (23132-21-0) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol

5-bromo-3-picoline (3430-16-8) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); ammonia; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; sodium t-butanolate In 1,4-dioxane for 24h; Reagent/catalyst;	86 %Chromat.

3-chloro-5-nitropyridine (22353-33-9) → 5-methylpyridin-3-amine (3430-19-1)

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol

5-methylpyridin-3-amine (3430-19-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(5-methylpyridin-3-yl)carbamate (631910-23-1)

Conditions	Yield
Stage #1: 5-methylpyridin-3-amine With sodium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.25h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃;	88%
With sodium hexamethyldisilazane In tetrahydrofuran at 20℃;	88%
Stage #1: 5-methylpyridin-3-amine With sodium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.25h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃;	88%

5-methylpyridin-3-amine (3430-19-1) + 2-(4-(2-bromobenzoyl)phenoxy)acetic acid → 2-[4-(2-bromobenzoyl)phenoxy]-N-(5-methylpyridin-3-yl)acetamide

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	86%

5-methylpyridin-3-amine (3430-19-1) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → benzyl (S)-2-((5-methylpyridin-3-yl)carbamoyl)pyrrolidine-1-carboxylate

Conditions	Yield
Stage #1: N-Benzyloxycarbonyl-L-proline With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 5-methylpyridin-3-amine In tetrahydrofuran at 0 - 70℃; for 25h; Inert atmosphere;	81%

5-methylpyridin-3-amine (3430-19-1) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(5-methylpyridin-3-yl)acetamide

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	79%

5-methylpyridin-3-amine (3430-19-1) + 1,1'-carbonyldiimidazole (530-62-1) → 1,3-bis(5-methylpyridin-3-yl)urea (1387638-53-0)

Conditions	Yield
In toluene at 20 - 80℃;	75%

5-methylpyridin-3-amine (3430-19-1) + ethyl acetoacetate (141-97-9) → N-(5-methylpyridin-3-yl)-3-oxobutanamide

Conditions	Yield
With sodium hydroxide In toluene at 100℃; for 10h;	75%
In toluene at 100℃; for 10h;	75%

5-methylpyridin-3-amine (3430-19-1) + phenyl chloroformate (1885-14-9) → (5-methyl-pyridin-3-yl)-carbamic acid phenyl ester (438190-95-5)

Conditions	Yield
With pyridine In tetrahydrofuran	71%
With pyridine In tetrahydrofuran at 0℃;	71%

5-methylpyridin-3-amine (3430-19-1) + suberic acid monomethyl ester (3946-32-5) → methyl 8-((5-methylpyridin-3-yl)amino)-8-oxooctanoate

Conditions	Yield
With N,N,N'N'-tetramethyl-1,3-propanediamine; boric acid In 1,3,5-trimethyl-benzene at 164℃; for 7h; Dean-Stark; Inert atmosphere; Green chemistry; regiospecific reaction;	70%

5-methylpyridin-3-amine (3430-19-1) + 4-chloro-7-nitroisobenzofuran-1,3-dione → 4-chloro-2-(5-methylpyridin-3-yl)-7-nitroisoindoline-1,3-dione

Conditions	Yield
With acetic acid at 120℃; for 12h;	64.5%
In acetic acid for 18h; Reflux;

5-methylpyridin-3-amine (3430-19-1) + 3-{1-[(6-chloropyrazin-2-yl)amino]ethyl}benzoic acid (1027256-79-6) → 3-{1-[(6-chloropyrazin-2-yl)amino]ethyl}-N-(5-methylpyridin-3-yl)benzamide (1027253-93-5)

Conditions	Yield
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 17h;	61%

5-methylpyridin-3-amine (3430-19-1) + (R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2,3:3,4]benzo[1,2-d]thiazol-7-yl)methyl carbonochloridate → (R)-(2-(2-methoxy-7-methylquinoxalin-5-yl)-4-methyl-7,8-dihydro-[1,4]dioxino[2’,3‘:3,4]benzo[1 ,2-d]thiazol-7-yl)methyl (5-methylpyridin-3-yl)carbamate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; carbonic acid dimethyl ester In tetrahydrofuran; dichloromethane at 20℃;	53.9%

5-methylpyridin-3-amine (3430-19-1) + 4-(((4-(tert-butyl)phenyl)sulfonamido)methyl)benzoic acid → 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(5-methyl-3-pyridinyl)benzamide

Conditions	Yield
Stage #1: 4-(((4-(tert-butyl)phenyl)sulfonamido)methyl)benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 20 - 66℃; for 3h; Stage #2: 5-methylpyridin-3-amine With pyridine at 20℃; for 16h;	50%

5-methylpyridin-3-amine (3430-19-1) + 2,4-dibromo-butyryl bromide (52412-07-4) → 3-bromo-1-(5-methylpyridin-3-yl)-2-oxopyrrolidine

Conditions	Yield
Stage #1: 5-methylpyridin-3-amine; 2,4-dibromo-butyryl bromide In dichloromethane at 0 - 20℃; for 3h; Stage #2: With sodium hydroxide In dichloromethane; water at 20℃; for 3h;	49.2%

5-methylpyridin-3-amine (3430-19-1) + (R)-(4-chloro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7 8-dihydro-[1,4]dioxino[2',3':3,4]benzo[1,2-d]thiazol-7-yl)methyl carbonochloridate → (R)-(4-chloro-2-(2,7-dimethylquinoxalin-5-yl)-7,8-dihydro-[1,4]dioxino[2',3':3,4]benzo[1,2-d]thiazol-7-yl)methyl (5-methylpyridin-3-yl)carbamate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; dichloromethane; toluene at 20℃; for 0.5h;	46.3%

5-methylpyridin-3-amine (3430-19-1) + bis(trichloromethyl) carbonate (32315-10-9) + (4S)-7-(2-methylpyridin-4-yl)-2,3,4,5-tetrahydro-1,4-methanopyrido[2,3-b][1,4]diazepine → (9S)-N-(5-methylpyridin-3-yl)-5-(2-methylpyridin-4-yl)-1,6,8-triazatricyclo[7.2.1.02,7]dodeca-2(7),3,5-triene-8-carboxamide

Conditions	Yield
Stage #1: 5-methylpyridin-3-amine; bis(trichloromethyl) carbonate; (4S)-7-(2-methylpyridin-4-yl)-2,3,4,5-tetrahydro-1,4-methanopyrido[2,3-b][1,4]diazepine In tetrahydrofuran at 30℃; for 1h; Stage #2: 5-methylpyridin-3-amine With triethylamine at 30 - 65℃; for 16h;	45%
Stage #1: bis(trichloromethyl) carbonate; (4S)-7-(2-methylpyridin-4-yl)-2,3,4,5-tetrahydro-1,4-methanopyrido[2,3-b][1,4]diazepine In tetrahydrofuran at 30℃; for 1h; Stage #2: 5-methylpyridin-3-amine With triethylamine In tetrahydrofuran at 65℃; for 16h;	45%

5-methylpyridin-3-amine (3430-19-1) + 1-(5-(4,6-dichloropyrimidin-2-yl)-2-methylpiperidin-1-yl)ethan-1-one → (+/-)-cis-1-(5-(4-chloro-6-((5-methylpyridin-3-yl)amino)pyrimidin-2-yl)-2-methylpiperidin-1-yl)ethan-1-one

Conditions	Yield
Stage #1: 5-methylpyridin-3-amine With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 1-(5-(4,6-dichloropyrimidin-2-yl)-2-methylpiperidin-1-yl)ethan-1-one In tetrahydrofuran at 20℃; for 16h;	45%

5-methylpyridin-3-amine (3430-19-1) + bis(trichloromethyl) carbonate (32315-10-9) + (S)-N-[1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-amine (1027255-35-1) → N-(3-{(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl}phenyl)-N'-(5-methylpyridin-3-yl)urea (1027253-94-6)

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; (S)-N-[1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-amine With sodium hydrogencarbonate In dichloromethane; water for 3h; Stage #2: 5-methylpyridin-3-amine In dichloromethane; water for 17h;	42%

5-methylpyridin-3-amine (3430-19-1) + (R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl carbonochloridate → (R)-(5-fluoro-2-(2-methoxy-7-methylquinoxalin-5-yl)-7,8-dihydrobenzofuro[5,4-d]thiazol-7-yl)methyl (5-methoxypyridin-3-yl)carbamate

Conditions	Yield
With pyridine; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;	39.6%

5-methylpyridin-3-amine (3430-19-1) + iodobenzene (591-50-4) + bis(pinacol)diborane (73183-34-3) → 3-methyl-5-phenylpyridine (10477-94-8)

Conditions	Yield
Stage #1: 5-methylpyridin-3-amine; bis(pinacol)diborane With tert.-butylnitrite In acetonitrile at 80℃; for 2h; Stage #2: iodobenzene With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;	35%

5-methylpyridin-3-amine (3430-19-1) + 2-methoxycarbonylbenzenesulfonyl chloride (26638-43-7) → methyl 2-{[(5-methylpyridin-3-yl)amino]sulfonyl}benzoate (931126-93-1)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	34%

5-methylpyridin-3-amine (3430-19-1) + bis(trichloromethyl) carbonate (32315-10-9) + (S)-6-(3-(3-fluoropyrrolidin-1-yl)phenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine → (S)-6-(3-(3-fluoropyrrolidin-1-yl)phenyl)-2,2-dimethyl-N-(5-methylpyridin-3-yl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide (1303585-09-2)

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; (S)-6-(3-(3-fluoropyrrolidin-1-yl)phenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine With triethylamine In tetrahydrofuran at 20℃; for 1.5h; Stage #2: 5-methylpyridin-3-amine In tetrahydrofuran at 60℃; for 18h;	31%

5-methylpyridin-3-amine (3430-19-1) + bis(trichloromethyl) carbonate (32315-10-9) + 7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (1303588-28-4) → N-(5-methylpyridin-3-yl)-7-(3-(trifluoromethyl)phenyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (1303583-59-6)

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; 7-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydro-1,8-naphthyridine With triethylamine In tetrahydrofuran at 30℃; for 0.5h; Inert atmosphere; Stage #2: 5-methylpyridin-3-amine In tetrahydrofuran at 60℃; for 18h; Inert atmosphere;	27%

5-methylpyridin-3-amine (3430-19-1) → 3-amino-2,6-dibromo-5-methylpyridine (126325-51-7) + 3-amino-2-bromo-5-methylpyridine (34552-14-2) + 3-amino-2,4,6-tribromo-5-methylpyridine

Conditions	Yield
With hydrogen bromide; dihydrogen peroxide at 70℃; for 1h; Product distribution;	A 26% B 6% C 0.5%
With hydrogen bromide; dihydrogen peroxide at 70℃; for 1h;	A 26% B 6% C 0.5%

5-methylpyridin-3-amine (3430-19-1) + 1-(3-chloro-5-methyl-5H-chromeno[4,3-c]pyridin-8-yl)pyrrolidin-2-one → 1-(5-methyl-3-((5-methylpyridin-3-yl)amino)-5H-chromeno[4,3-c]pyridin8-yl)pyrrolidin-2-one

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate In 1,4-dioxane at 100℃; for 16h; Inert atmosphere;	22%

5-methylpyridin-3-amine (3430-19-1) + bis(trichloromethyl) carbonate (32315-10-9) + 2,2-dimethyl-6-(3-(pyrrolidin-1-ylmethyl)phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (1303588-19-3) → 2,2-dimethyl-N-(5-methylpyridin-3-yl)-6-(3-(pyrrolidin-1-ylmethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxamide (1303584-47-5)

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; 2,2-dimethyl-6-(3-(pyrrolidin-1-ylmethyl)phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine With triethylamine In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 5-methylpyridin-3-amine In tetrahydrofuran at 60℃;	20%

5-methylpyridin-3-amine (3430-19-1) + 1-[(4-bromophenyl)carbamoylamino]cyclopentanecarboxylic acid → 1-[(4-bromophenyl)carbamoylamino]-N-(5-methyl-3-pyridyl)cyclopentanecarboxamide

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate at 20℃;	20%

5-methylpyridin-3-amine (3430-19-1) + thiophosgene (463-71-8) → 3-isothiocyanato-5-methylpyridine

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 2h;	19%

Upstream product

• 22353-33-9 3-chloro-5-nitropyridine 
• 7598-26-7 5-Methyl-3-nitro-2-aminopyridine 
• 21901-34-8 2-hydroxy-3-methyl-5-nitropyridine 
• 18344-51-9 2-amino-3-methyl-5-nitropyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 591-22-0 3,5-Lutidine 
• 70-57-5 5-methylpyridinylcarboxamide 
• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 3222-49-9 5-methylnicotinic acid 
• 3430-16-8 5-bromo-3-picoline 
• 23132-21-0 2-bromo-3-methyl-5-nitropyridine 
• 884494-95-5 5-methyl-nicotinic acid chloride 

Downstream Products

• 455-70-9 5-fluoro-3-pyridinecarboxylic acid methyl ester 
• 39891-04-8 5-fluoropyridine-3-carboxaldehyde 
• 22620-32-2 (5-fluoropyridin-3-yl)methanol 
• 114995-63-0 (2-Amino-3,5-difluoro-phenyl)-(5-fluoro-pyridin-3-yl)-methanone 
• 350-04-9 5-fluoro-3-pyridinecarbonyl chloride 
• 3430-16-8 5-bromo-3-picoline 
• 126325-51-7 3-amino-2,6-dibromo-5-methylpyridine 
• 34552-14-2 3-amino-2-bromo-5-methylpyridine 
• 1270019-95-8 cis-(+/-)-tert-butyl 5-methylpiperidin-3-ylcarbamate 

Relevant articles and documents

Synthesis method of 3-bromo-5-methylpyridine

The invention relates to the field of organic chemistry and particularly provides a synthesis method of 3-bromo-5-methylpyridine. The synthesis method includes the steps of: 1) performing a reaction to diethyl malonate and alkaline metal to generate a salt, and dropwise adding a toluene solution of 3-nitro-5-chloropyridine to perform a condensation reaction, and decarboxylating the product under an acidic condition to obtain 3-nitro-5-methylpyridine; 2) performing hydrogenation reduction to the 3-nitro-5-methylpyridine with Pd/C as a catalyst and methanol as a solvent, performing suction filtration and concentrating a filtrate to prepare 3-amino-5-methylpyridine; and 3) performing a reaction to the 3-amino-5-methylpyridine with an acid to generate a salt, and cooling the salt to -10 - 0 DEG C, dropwise adding liquid bromine, and then dropwise adding a sodium nitrite water solution, regulating the pH value of the solution to alkalinity and performing extraction, drying and concentration to obtain the 3-bromo-5-methylpyridine. The synthesis method is mild in reaction conditions, is high in yield, employs easy-to-obtained raw materials, is low in cost, is short in process route and has industrial prospect.

COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS

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