455-70-9

Basic information

• Product Name: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
• Synonyms: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE;Methyl5-fluoronicotinate;5-Fluoropyridine-3-carboxylic acid methyl ester;5-Fluoro-nicotinic acid methyl ester;Methyl 5-fluoro-3-pyridinecarboxylate;3-Pyridinecarboxylic acid, 5-fluoro-, methyl ester;3-PYRIDINECARBONYL CHLORIDE, 5-FLUORO-, METHYL ESTER
• CAS NO: 455-70-9
• Molecular Formula: C₇H₆FNO₂
• Molecular Weight: 155.13
• Mol File: 455-70-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 194.5°Cat760mmHg
• Flash Point: 71.4°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 0.441mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.77±0.20(Predicted)
• CAS DataBase Reference: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE(455-70-9)
• EPA Substance Registry System: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE(455-70-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-70-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

Methyl 5-fluoronicotinate

InChI:InChI=1/C7H6FNO2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,1H3

Upstream product

• 36052-25-2 5-amino-nicotinic acid methyl ester 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 67-56-1 methanol 
• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 30766-22-4 methyl 5-hydroxy-3-pyridinecarboxylate 
• 342024-50-4 methyl 5-triflatonicotinate 
• 884494-95-5 5-methyl-nicotinic acid chloride 
• 70-57-5 5-methylpyridinylcarboxamide 
• 3222-49-9 5-methylnicotinic acid 
• 3430-19-1 5-methylpyridin-3-amine 
• 407-21-6 5-methyl-3-fluoropyridine 
• 591-22-0 3,5-Lutidine 
• 186581-53-3 diazomethane 

Downstream Products

• 39891-04-8 5-fluoropyridine-3-carboxaldehyde 
• 114995-63-0 (2-Amino-3,5-difluoro-phenyl)-(5-fluoro-pyridin-3-yl)-methanone 
• 39891-37-7 3-(chloromethyl)-5-fluoropyridine 
• 22620-32-2 (5-fluoropyridin-3-yl)methanol 
• 701-40-6 5-fluoropyridine-3-carbohydrazide 

Relevant articles and documents

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BICYCLIC PYRROLOTRIAZOLR KETONE COMPOUNDS AND METHODS OF USE THEREOF

Some embodiments of the invention provide compounds having the general formula (I) wherein R1, R2, R3a and R3b are as described herein, pharmaceutical compositions including the compounds, and the compounds for use in methods of treating illnesses.

PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols

A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.