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70380-70-0

70380-70-0

Identification

Synonyms:5-(2-Thienyl)oxazole;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:TRC
  • Product Description:5-(2-thienyl)-1,3-oxazole
  • Packaging:100mg
  • Price:$ 45
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:5-(2-thienyl)-1,3-oxazole
  • Packaging:1g
  • Price:$ 200
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:5-(2-thienyl)-1,3-oxazole
  • Packaging:500mg
  • Price:$ 130
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:5-(Thiophen-2-yl)oxazole 97%
  • Packaging:1g
  • Price:$ 842
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:5-(thiophen-2-yl)oxazole 97%
  • Packaging:1g
  • Price:$ 795
  • Delivery:In stock
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:5-(2-Thienyl)-1,3-oxazole 95%
  • Packaging:1gm:
  • Price:$ 95.43
  • Delivery:In stock
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  • Manufacture/Brand:Arctom
  • Product Description:5-(Thiophen-2-yl)oxazole
  • Packaging:1g
  • Price:$ 684
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-(2-THIENYL)-1,3-OXAZOLE 95.00%
  • Packaging:25G
  • Price:$ 2393.97
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-(2-THIENYL)-1,3-OXAZOLE 95.00%
  • Packaging:10G
  • Price:$ 1794.87
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-(2-THIENYL)-1,3-OXAZOLE 95.00%
  • Packaging:1G
  • Price:$ 770.1
  • Delivery:In stock
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Relevant articles and documentsAll total 11 Articles be found

A One-Pot Tandem Approach for the Synthesis of 5-(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides

Vinay Kumar, Koravangala S.,Swaroop, Toreshettahally R.,Rajeev, Narasimhamurthy,Vinayaka, Ajjampura C.,Lingaraju, Gejjalagere S.,Rangappa, Kanchugarakoppal S.,Sadashiva, Maralinganadoddi P.

supporting information, p. 1363 - 1366 (2016/06/01)

A new modified van Leusen strategy has been developed for the synthesis of biologically significant 5-substituted oxazoles by the reaction of (het)aryl methyl alcohols or benzyl bromides as precursors with tosylmethylisocyanide (TosMIC) under basic conditions. This method is efficient, takes place under mild reaction conditions, and is tolerant of various functional groups with high yield.

Cobalt-catalyzed addition of azoles to alkynes

Ding, Zhenhua,Yoshikai, Naohiko

supporting information; experimental part, p. 4180 - 4183 (2010/11/19)

A ternary catalytic system consisting of a cobalt salt, a diphosphine ligand, and a Grignard reagent promotes syn-addition of an azole C(2)-H bond across an unactivated internal alkyne with high chemo-, regio-, and stereoselectivities under mild conditions. Mechanistic experiments suggest that the reaction involves oxidative addition of the oxazolyl C-H bond to the cobalt center, alkyne insertion into the Co-H bond, and reductive elimination of the resulting diorganocobalt species.

Heterocyclizations via TosMIC-based multicomponent reactions: A new approach to one-pot facile synthesis of substituted quinoxaline derivatives

Neochoritis, Constantinos,Stephanidou-Stephanatou, Julia,Tsoleridis, Constantinos A.

scheme or table, p. 302 - 305 (2009/06/23)

A novel multicomponent reaction involving o-phenylenediamines, aldehydes and p-toluenesulfonylmethyl isocyanide (TosMIC) in the presence of a base leading to the formation of quinoxalines in very good yields is described. Georg Thieme Verlag Stuttgart.

Process route upstream and downstream products

Process route

thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(thiophen-2-yl)quinoxaline
40353-41-1

2-(thiophen-2-yl)quinoxaline

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 80 ℃; for 4h;
47%
40%
[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

2-thiophenemethanol
636-72-6

2-thiophenemethanol

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
[(p-methylphenyl)sulfonylmethyl]isonitrile; 2-thiophenemethanol; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dimethyl sulfoxide; ethyl acetate; at 0 ℃; for 1.5h; Inert atmosphere;
With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.0833333h;
69%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With potassium carbonate; In methanol; at 66 ℃; for 4h; Inert atmosphere;
84%
With potassium carbonate; In methanol;
With potassium carbonate; In methanol; for 24h; Heating;
With potassium carbonate; In methanol; Heating;
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

p-toluenesulfonylmethyl isocyanide
113077-70-6

p-toluenesulfonylmethyl isocyanide

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With potassium carbonate; In methanol; for 5h; Heating / reflux;
37%
2-thiophenecarboxaldehyde diacetate
63011-97-2

2-thiophenecarboxaldehyde diacetate

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With potassium carbonate; In methanol; at 55 ℃; for 16h;
94%
With potassium carbonate; In methanol; at 55 ℃; for 2h; Cooling;
2-thiopheneglyoxylic acid
4075-59-6

2-thiopheneglyoxylic acid

p-tosylmethyl isocyanide

p-tosylmethyl isocyanide

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
2-thiopheneglyoxylic acid; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
p-tosylmethyl isocyanide; With 1,10-Phenanthroline; copper(l) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 12h;
45%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

1-(isocyanomethyloxy)benzotriazole
195711-05-8

1-(isocyanomethyloxy)benzotriazole

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With potassium tert-butylate; In tetrahydrofuran; for 2h; Ambient temperature;
91%
diphenylmethyl 3,5-bis(trifluoromethyl)phenylsulfone

diphenylmethyl 3,5-bis(trifluoromethyl)phenylsulfone

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

2-benzhydryl-5-(2-thienyl)oxazole

2-benzhydryl-5-(2-thienyl)oxazole

Conditions
Conditions Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,3-bis-(diphenylphosphino)propane; lithium tert-butoxide; In 1,4-dioxane; at 120 ℃; for 12h; Sealed tube; Inert atmosphere; Schlenk technique;
66%
1-(2,2-dichlorovinyl)-4-methoxybenzene
41448-64-0

1-(2,2-dichlorovinyl)-4-methoxybenzene

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

2-{(4-methoxyphenyl)ethynyl}-5-(thiophen-2-yl)oxazole
1370422-92-6

2-{(4-methoxyphenyl)ethynyl}-5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; lithium tert-butoxide; In 1,4-dioxane; at 120 ℃; for 14h; Inert atmosphere;
57%
(2,2-dichlorovinyl)benzene
698-88-4

(2,2-dichlorovinyl)benzene

5-(thiophen-2-yl)oxazole
70380-70-0

5-(thiophen-2-yl)oxazole

2-(phenylethynyl)-5-(thiophen-2-yl)oxazole
1370422-90-4

2-(phenylethynyl)-5-(thiophen-2-yl)oxazole

Conditions
Conditions Yield
With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; lithium tert-butoxide; In 1,4-dioxane; at 120 ℃; for 14h; Inert atmosphere;
52%

Global suppliers and manufacturers

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  • Finetech Industry Limited
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  • Antimex Chemical Limied
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  • Tianjin SPHINX SCIENTIFIC LAB.
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  • Debye Scientific
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