70738-04-4Relevant articles and documents
Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α-Ketols: Convergent Construction of Angucycline Ring Systems
Saxena, Aakarsh,Perez, Felix,Krische, Michael J.
, p. 1493 - 1497 (2016)
Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with α-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type€...II polyketide ring systems of the angucycline class. Ringing with efficiency: Ruthenium(0) complexes modified by either CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with α-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type€...II polyketide ring systems of the angucycline class.
Total Synthesis of Frustulosin and Aurocitrin
Ronald, Robert C.,Lansinger, Janet M.,Lillie, Thomas S.,Wheeler, Carl J.
, p. 2541 - 2549 (2007/10/02)
The regioselective total syntheses of the novel fungal antibiotics frustulosin (1) and aurocitrin (2) were accomplished from 3,6-dihydroxy-2-iodobenzaldehyde (10) which was prepared by a regiodirected metalation of 2,5-dimethylbenzyl vinyl ether to establish the 1,2,3,4-tetrasubstitution pattern of these compounds.The unsaturated side chains of these hydroquinone antibiotics were attached by using the iodo aldehyde functionalities.The structures of these antibiotics are confirmed by synthesis.