63160-44-1

Upstream product

• 63160-46-3 2,5-dihydroxy-6-(3-methylbut-3-en-1-ynyl)benzaldehyde 
• 1194-98-5 2,5-Dihydroxybenzaldehyde 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 81477-63-6 bis(tert-butyldimethylsilyl)frustulosin 
• 81477-61-4 2-iodo-3,6-bis<(tert-butyldimethylsilyl)oxy>benzaldehyde 
• 71255-05-5 2-iodo-3,6-dimethoxybenzyl vinyl ether 
• 71255-03-3 2,5-dimethoxybenzyl vinyl ether 
• 71255-06-6 2-iodo-3,6-dimethoxybenzyl alcohol 
• 70738-04-4 2-iodo-3,6-dimethoxybenzaldehyde 
• 70738-05-5 2-iodo-3,6-dihydrobenzaldehyde 
• 241127-72-0 2-bromo-3,6-dihydroxy-benzaldehyde 
• 877319-67-0 2-hydroxy-5-(methoxymethyloxy)-6-(3-methylbut-3-en-1-ynyl)benzaldehyde 
• 877319-66-9 2-bromo-6-hydroxy-3-methoxymethoxy-benzaldehyde 

Downstream Products

• 63160-50-9 2-Hydroxymethyl-3-(3-methyl-but-3-en-1-ynyl)-[1,4]benzoquinone 

Relevant academic research and scientific papers

Total synthesis of bioactive frustulosin and frustulosinol

Stereum hirsutum is a pathogenic fungus involved in 'Esca', a trunk wood disease of grapevine. Among the metabolites isolated from the culture medium of this fungus, frustulosin (2a) shows a high phytotoxicity. A new simple and efficient method for the sy

Total Synthesis of Frustulosin and Aurocitrin

The regioselective total syntheses of the novel fungal antibiotics frustulosin (1) and aurocitrin (2) were accomplished from 3,6-dihydroxy-2-iodobenzaldehyde (10) which was prepared by a regiodirected metalation of 2,5-dimethylbenzyl vinyl ether to establish the 1,2,3,4-tetrasubstitution pattern of these compounds.The unsaturated side chains of these hydroquinone antibiotics were attached by using the iodo aldehyde functionalities.The structures of these antibiotics are confirmed by synthesis.