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N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER is a chemical compound with the formula C16H25NO4. It is a white or off-white crystalline powder that is commonly used in organic synthesis and pharmaceutical research. N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER is a derivative of piperidine and is often used as an intermediate in the production of various pharmaceuticals and biologically active compounds. Additionally, it serves as a protecting group in peptide synthesis to protect the amino group of the piperidine ring. N-CBZ-2-piperidinecarboxylic acid t-butyl ester is considered to be stable under normal conditions and is typically stored in a cool, dry place away from direct sunlight and moisture.

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  • 71170-89-3 Structure
  • Basic information

    1. Product Name: N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER
    2. Synonyms: N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER
    3. CAS NO:71170-89-3
    4. Molecular Formula: C18H25NO4
    5. Molecular Weight: 319.4
    6. EINECS: N/A
    7. Product Categories: pharmacetical
    8. Mol File: 71170-89-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER(71170-89-3)
    11. EPA Substance Registry System: N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER(71170-89-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 71170-89-3(Hazardous Substances Data)

71170-89-3 Usage

Uses

Used in Pharmaceutical Research:
N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER is used as an intermediate in the synthesis of various pharmaceuticals and biologically active compounds. Its role in the production process is crucial for creating a range of medications that target different health conditions.
Used in Organic Synthesis:
In the field of organic synthesis, N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER is utilized as a key component in the creation of complex organic molecules. Its unique structure allows it to participate in various chemical reactions, contributing to the development of new organic compounds.
Used as a Protecting Group in Peptide Synthesis:
N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER is used as a protecting group in peptide synthesis to shield the amino group of the piperidine ring. This protection is essential during the synthesis process to prevent unwanted side reactions and ensure the correct formation of peptide bonds.

Check Digit Verification of cas no

The CAS Registry Mumber 71170-89-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,1,7 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 71170-89:
(7*7)+(6*1)+(5*1)+(4*7)+(3*0)+(2*8)+(1*9)=113
113 % 10 = 3
So 71170-89-3 is a valid CAS Registry Number.

71170-89-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-O-benzyl 2-O-tert-butyl piperidine-1,2-dicarboxylate

1.2 Other means of identification

Product number -
Other names N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71170-89-3 SDS

71170-89-3Relevant articles and documents

Ring-Strain Effects in Base-Induced Sommelet–Hauser Rearrangement: Application to Successive Stereocontrolled Transformations

Tayama, Eiji,Watanabe, Kazutoshi,Matano, Yoshihiro

supporting information, p. 3631 - 3641 (2016/07/29)

The base-induced Sommelet–Hauser (S–H) rearrangement of azetidine-2-carboxylic acid ester-derived ammonium salts into 2-aryl-substituted derivatives was demonstrated. The ring-strain of four-membered N-heterocycles enables efficient generation of the desired ylide intermediate and enhances the rate of the S–H rearrangement. The asymmetric version of the rearrangement was characterized by excellent levels of successive chirality transmissions. The regio- and stereo-controlled nucleophilic ring opening of the rearrangement products produced quaternary α-aryl amino acid esters with excellent enantiopurities.

Design, Synthesis, and X-ray Crystallographic Analysis of Two Novel Spirolactam Systems as β-Turn Mimics

Genin, Michael J.,Gleason, William B.,Johnson, Rodney L.

, p. 860 - 866 (2007/10/02)

Two novel 5.4-spirolactam systems have been developed as β-turn mimics.The (R)-5.4-spirolactam system of 4 was designed to mimic the type-II β-turn, and the (S)-5.4-spirolactam system of 5 was designed to mimic the type-II' β-turn.The 5.4-spirolactam dipe

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