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71875-81-5

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  • Cyclohexanecarboxylicacid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-,2,5-dioxo-1-pyrrolidinyl ester, trans-

    Cas No: 71875-81-5

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  • Cyclohexanecarboxylicacid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-,2,5-dioxo-1-pyrrolidinyl ester, trans-

    Cas No: 71875-81-5

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71875-81-5 Usage

General Description

Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid-NHS is a chemical compound that is commonly used in bioconjugation and crosslinking applications. It consists of a maleimide group, which is known for its reactivity towards thiol-containing molecules, and an NHS ester, which allows for the covalent attachment of the compound to primary amines. This reactivity makes it a valuable tool for the conjugation of proteins, peptides, and other biomolecules, as well as for the creation of targeted drug delivery systems and various biotechnology applications. Additionally, the cyclohexane ring in the molecule provides stability and rigidity, making it suitable for use in a wide range of experimental conditions. Overall, Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid-NHS is a versatile and valuable reagent in the field of chemical biology and biochemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 71875-81-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,8,7 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71875-81:
(7*7)+(6*1)+(5*8)+(4*7)+(3*5)+(2*8)+(1*1)=155
155 % 10 = 5
So 71875-81-5 is a valid CAS Registry Number.

71875-81-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(trans-4-{[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl}cyclohexyl)m ethyl]-1H-pyrrole-2,5-dione

1.2 Other means of identification

Product number -
Other names trans-Cyclohexanecarboxylic Acid 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-,2,5-dioxo-1-pyrrolidinyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:71875-81-5 SDS

71875-81-5Relevant articles and documents

Rapid Diels-Alder Cross-linking of Cell Encapsulating Hydrogels

Madl, Christopher M.,Heilshorn, Sarah C.

, p. 8035 - 8043 (2019/10/21)

Recent efforts in the design of hydrogel biomaterials have focused on better mimicking the native cellular microenvironment to direct cell fate. To simultaneously control multiple material parameters, several orthogonal chemistries may be needed. However, present strategies to prepare cell-encapsulating hydrogels make use of relatively few chemical reactions. To expand this chemical toolkit, we report the preparation of hydrogels based on a Diels-Alder reaction between fulvenes and maleimides with markedly improved gelation kinetics and hydrolytic stability. Fulvene-maleimide gels cross-link up to 10-times faster than other commonly used DA reaction pairs and remain stable for months under physiological conditions. Furthermore, fulvene-maleimide gels presenting relevant biochemical cues, such as cell-adhesive ligands and proteolytic degradability, support the culture of human mesenchymal stromal cells. Finally, this rapid DA reaction was combined with an orthogonal click reaction to demonstrate how the use of selective chemistries can provide new avenues to incorporate multiple functionalities in hydrogel materials.

PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES

-

, (2015/03/16)

The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The discl

In situ formation of N-trifluoroacetoxy succinimide (TFA-NHS): One-pot formation of succinimidyl esters, N-trifluoroacetyl amino acid succinimidyl esters, and N-maleoyl amino acid succinimidyl esters

Leonard, Nicholas M.,Brunckova, Jarmila

, p. 9169 - 9174 (2011/12/16)

A method for the in situ formation of N-trifluoroacetoxy succinimide (TFA-NHS) and its application in the formation of succinimidyl esters is presented. The developed method provides N-trifluoroacetyl and N-maleoyl amino acid succinimidyl esters from a variety of amino acids using a one-pot, high-yielding protocol. Investigations into the formation of an N-maleoyl amino acid succinimidyl ester supported the proposal of a revised reaction mechanism, and contributed to the optimization of the reaction conditions.

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