5672-89-9

Basic information

• Product Name: N-Succinimidyl Trifluoroacetate
• Synonyms: N-Succinimidyl Trifluoroacetate;NHS-TFA;N-Succinimidyl Trifluoroacetate
• CAS NO: 5672-89-9
• Molecular Formula: C₆H₄F₃NO₄
• Molecular Weight: 211.0954696
• Mol File: 5672-89-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 100°C/3mmHg(lit.)
• Appearance: /
• Density: 1.62±0.1 g/cm3(Predicted)
• Solubility: soluble in Methanol
• CAS DataBase Reference: N-Succinimidyl Trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: N-Succinimidyl Trifluoroacetate(5672-89-9)
• EPA Substance Registry System: N-Succinimidyl Trifluoroacetate(5672-89-9)

Safety Data

• Hazardous Substances Data: 5672-89-9(Hazardous Substances Data)

Usage

Uses

O-(Trifluoroacetyl)-N-hydroxysuccinimide is used to prepare fluorinated xanthene derivatives as fluorescent dyes with use in staining biological materials.

Upstream product

• 39651-54-2 N-(trifluoroacetyl)-N-methyl-4-nitroaniline 
• 67007-51-6 N-hydroxysuccinimide potassium salt 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 30364-60-4 1,1'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]di(pyrrolidine-2,5-dione) 
• 7387-69-1 N-benzyl-2,2,2-trifluoroacetamide 
• 68464-36-8 N-benzyl-2,2,2,-trifluoro-N-methylacetamide 
• 199293-83-9 3-[9-({{4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl}[(4-methylphenyl)sulfonyl]amino}carbonyl)-10-acridiniumyl]-1-propanesulfonate 
• 58626-38-3 1-(3-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-1H-pyrrole-2,5-dione 
• 66832-27-7 3-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-4-methoxy-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 71875-81-5 4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester 
• 64191-06-6 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate 
• 2709-93-5 N-trifluoroacetyl-4-aminophenol 
• 1351636-87-7 C₃₂H₄₇N₇O₁₅ 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 151915-24-1 N-Succinimidyl 4(S)-<(tert-butyldiphenylsilyl)oxy>-5(E),7-octadienoate 
• 110096-42-9 (S)-2-Benzyloxycarbonylamino-but-3-enoic acid 2,5-dioxo-pyrrolidin-1-yl ester 

Relevant articles and documents

Argininamide-type neuropeptide y Y1 receptor antagonists: The nature of: N Ω-carbamoyl substituents determines Y1R binding mode and affinity

The recently resolved crystal structure of the neuropeptide Y Y1 receptor (Y1R), co-crystallized with the high-affinity (pKi: 10.11), argininamide-type Y1R antagonist UR-MK299 (2), revealed that the NΩ-carbamoyl substituent (van der Waals volume: 139 ?3) is deeply buried in the receptor, occupying a hydrophobic pocket. We synthesized and characterized a series of argininamides, structurally related to 2. Y1R affinity decreased with increasing size of the carbamoyl residue (minimal pKi: 5.67). Exceeding a critical size of the substituent (van der Waals volume: 212 ?3), the ligands bound in an inverted mode with the carbamoyl side chain located at the surface of the receptor, as suggested by induced-fit docking and MD simulations.

Synthesis and Antitumor Activity of Conjugates Based on the Phe-D-Trp-Lys-Thr Peptide Fragment of Somatostatin

Abstract: New somatostatin analogs containing the fragments of adamantane, coumarin, tetrahydrocarbazole, and palmitic acid of the general formula R-Phe-D-Trp-Lys(Boc)-Thr-OMe have been synthesized. The structure of the conjugates combines a peptide fragm

A Practical Synthesis of 6,8-Difluoro-7-hydroxycoumarin Derivatives for Fluorescence Applications

A practical synthesis for 6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid - one of the most widely used coumarin fluorescence imaging dye for bioconjugation - is reported. The synthesis was optimized for a preparative scale to obtain 14 g of the fluoresc