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Basic information

• Product Name: 3-(TRIFLUOROMETHYL)BENZHYDROL
• Synonyms: 3-(TRIFLUOROMETHYL)BENZHYDROL;PHENYL[3-(TRIFLUOROMETHYL)PHENYL]METHANOL;M-TRIFLUOROMETHYLBENZHYDROL;Phenyl 3-trifluoromethylphenyl carbinol~3-(Trifluoromethyl)diphenylmethanol;3-(trifluoromethyl)diphenylmethanol;phenyl 3-trifluoromethylphenyl carbinol;3-(Trifluoromethyl)benzhydrol 97%;3-(Trifluoromethyl)benzhydrol97%
• CAS NO: 728-80-3
• Molecular Formula: C₁₄H₁₁F₃O
• Molecular Weight: 252.23
• EINECS: -0
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 728-80-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 62-66 °C(lit.)
• Boiling Point: 125-127°C 0,5mm
• Flash Point: 125-127°C/0.5mm
• Appearance: white solid
• Density: 1.257
• Vapor Pressure: 0.000283mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• PKA: 13.36±0.20(Predicted)
• BRN: 2418462
• CAS DataBase Reference: 3-(TRIFLUOROMETHYL)BENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TRIFLUOROMETHYL)BENZHYDROL(728-80-3)
• EPA Substance Registry System: 3-(TRIFLUOROMETHYL)BENZHYDROL(728-80-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: FLAMMABLE
• Hazardous Substances Data: 728-80-3(Hazardous Substances Data)

Usage

Chemical Properties

Solid

InChI:InChI=1/C14H11F3O/c15-14(16,17)12-8-4-7-11(9-12)13(18)10-5-2-1-3-6-10/h1-9,13,18H

Upstream product

• 728-81-4 3-(trifluoromethyl)benzophenone 
• 100-52-7 benzaldehyde 
• 98-15-7 3-chlorotrifluoromethylbenzene 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 100-51-6 benzyl alcohol 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 51339-26-5 (phenyl)(3-trifluoromethylphenyl)methyl bromide 
• 109-72-8 n-butyllithium 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 3216-13-5 4-[2-(3-trifluoromethyl-benzhydryloxy)-ethyl]-morpholine 
• 728-81-4 3-(trifluoromethyl)benzophenone 
• 51339-26-5 (phenyl)(3-trifluoromethylphenyl)methyl bromide 
• 75198-32-2 1-benzyl-3-(trifluoromethyl)benzene 
• 67240-79-3 1-(chloro(phenyl)methyl)-3-(trifluoromethyl)benzene 
• 176713-86-3 [Phenyl-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Catalytic Aldehyde and Alcohol Arylation Reactions Facilitated by a 1,5-Diaza-3,7-diphosphacyclooctane Ligand

We report a catalytic method to access secondary alcohols by the coupling of aryl iodides. Either aldehydes or alcohols can be used as reaction partners, making the transformation reductive or redox-neutral, respectively. The reaction is mediated by a Ni catalyst and a 1,5-diaza-3,7-diphosphacyclooctane. This P2N2ligand, which has previously been unrecognized in cross-coupling and related reactions, was found to avoid deleterious aryl halide reduction pathways that dominate with more traditional phosphines and NHCs. An interrupted carbonyl-Heck type mechanism is proposed to be operative, with a key 1,2-insertion step forging the new C-C bond and forming a nickel alkoxide that may be turned over by an alcohol reductant. The same catalyst was also found to enable synthesis of ketone products from either aldehydes or alcohols, demonstrating control over the oxidation state of both the starting materials and products.

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

Nonracemic diarylmethanols from CuH-catalyzed hydrosilylation of diaryl ketones

(Chemical Equation Presented) An efficient method for the synthesis of nonracemic diarylmethanols has been developed. The use of (R)-(-)-(DTBM-SEGPHOS) CuH effects highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones.