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74-54-4

1-(2-phenoxyethyl)pyrrolidine is a chemical compound with the molecular formula C11H15NO. It is a derivative of pyrrolidine, a heterocyclic amine, and features a phenoxyethyl group attached to the nitrogen atom. 1-(2-phenoxyethyl)pyrrolidine is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as a building block for the development of various biologically active molecules. Its structure provides a unique combination of a cyclic amine and an aryl ether, which can be further functionalized or used as a chiral auxiliary in asymmetric synthesis. The compound is also of interest in medicinal chemistry due to its potential to interact with biological targets through its basic nitrogen and aromatic ring.

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  • 74-54-4 Structure

  • Basic information

    1. Product Name: 1-(2-phenoxyethyl)pyrrolidine
    2. Synonyms: 1-(2-Phenoxy-ethyl)-pyrrolidine; Pyrrolidine, 1-(2-phenoxyethyl)-
    3. CAS NO:74-54-4
    4. Molecular Formula: C12H17NO
    5. Molecular Weight: 191.2695
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 74-54-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 294.4°C at 760 mmHg
    3. Flash Point: 86.8°C
    4. Appearance: N/A
    5. Density: 1.029g/cm3
    6. Vapor Pressure: 0.00163mmHg at 25°C
    7. Refractive Index: 1.532
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1-(2-phenoxyethyl)pyrrolidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(2-phenoxyethyl)pyrrolidine(74-54-4)
    12. EPA Substance Registry System: 1-(2-phenoxyethyl)pyrrolidine(74-54-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 74-54-4(Hazardous Substances Data)

74-54-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 74-54-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 74-54:
(4*7)+(3*4)+(2*5)+(1*4)=54
54 % 10 = 4
So 74-54-4 is a valid CAS Registry Number.

74-54-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-phenoxy-ethyl)-pyrrolidine

1.2 Other means of identification

Product number -
Other names 1-(2-Phenoxy-aethyl)-pyrrolidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74-54-4 SDS

74-54-4Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

Annatelli, Mattia,Trapasso, Giacomo,Salaris, Claudio,Salata, Cristiano,Castellano, Sabrina,Aricò, Fabio

supporting information, p. 3459 - 3464 (2021/05/24)

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

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