7514-02-5

Basic information

• Product Name: 3-(2-chlorophenyl)-2-phenylprop-2-enoic acid
• CAS NO: 7514-02-5
• Molecular Formula: C₁₅H₁₁ClO₂
• Molecular Weight: 258.6996
• Mol File: 7514-02-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 368.8°C at 760 mmHg
• Flash Point: 176.8°C
• Density: 1.299g/cm³
• Vapor Pressure: 4.34E-06mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 3-(2-chlorophenyl)-2-phenylprop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-2-phenylprop-2-enoic acid(7514-02-5)
• EPA Substance Registry System: 3-(2-chlorophenyl)-2-phenylprop-2-enoic acid(7514-02-5)

Safety Data

• Hazardous Substances Data: 7514-02-5(Hazardous Substances Data)

Upstream product

• 23074-53-5 <2-Chlor-phenyl>-cyclopropenon 
• 7647-01-0 hydrogenchloride 
• 71-43-2 benzene 
• 89-98-5 2-chloro-benzaldehyde 
• 114-70-5 sodium phenylacetate 
• 103-82-2 phenylacetic acid 

Downstream Products

• 1261237-38-0 (E)-N,N-diethyl-3-(2-chlorophenyl)-2-(phenyl)-prop-2-enamide 
• 1261237-36-8 (E)-N-methyl-3-(2-chlorophenyl)-2-(phenyl)-prop-2-enamide 
• 42307-44-8 (E)-methyl 3-(2-chlorophenyl)-2-(phenyl)-prop-2-enoate 
• 1657-52-9 (E)-2-chlorostilbene 
• 1657-51-8 (Z)-1-chloro-2-styrylbenzene 
• 1383121-08-1 (2R)-3-(2-chlorophenyl)-2-phenylpropanoic acid 

Relevant articles and documents

Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease

Twenty-eight compounds with a new scaffold were designed and synthesized by assembling fragments derived from known agents such as stilbenes and piperazinyl pyrimidines. Many strategies have been explored to improve the druggability of these series of compounds, such as increasing the distance between two benzene rings in the scaffold and introducing functional groups at designated positions. These compounds were validated for their anti-neuroinflammatory activity in BV2 cells. Experimental results reveal that the most active compound 8b can inhibit nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) production with IC50 values of 1.0, 2.6, and 0.5 μM, respectively. The compound can also significantly modulate the MAPK pathways through inhibiting the phosphorylation of JNK, ERK1/2, and p38 MAPK without disturbing NF-κB pathway. Parallel artificial membrane permeation assay demonstrated that the most active compound can overcome the blood-brain barrier (BBB). Therefore, this compound can be a promising lead for the treatment of Alzheimer's disease.

Synthesis and biological evaluation of some stilbene derivatives

Several trans and cis stilbenes with substitution n the olefinic bridge were synthesized and characterized by IR, NMR and mass spectroscopy in an effort to obtain ubstances that could be more readily formulated. All the synthesized compounds were screened against Molt4/C8, CEM and L1210 cell lines. None of these compounds were ndowed with pronounced cytostatic activity. However,Schiff derivatives emerged as cytostatic agents (IC50: 0.77-10 μg/ml) that deserve further investigation. Springer Science+Business Media, LLC 2010.