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Cas Database

75679-58-2

75679-58-2

Identification

  • Product Name:1/C17H18O5/c1-21-13-6-3-11(4-7-13)5-8-14(19)17-15(20)9-12(18)10-16(17)22-2/h3-4,6-7,9-10,18,20H,5,8H2,1-2H

  • CAS Number: 75679-58-2

  • EINECS:

  • Molecular Weight:302.327

  • Molecular Formula: C17H18O5

  • HS Code:

  • Mol File:75679-58-2.mol

Synonyms:2',4'-Dihydroxy-4,6'-dimethoxydihydrochalcone;.2',4'-Dihydroxy-4,6'-dimethoxydihydrochalcone;.4′,6′-dihydroxy-2′,4-dimethoxydihydrochalcone;dimethoxydihydrochalcone2',4'-Dihydroxy-4,6'-;2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone;1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one;.2',4'-dihydroxy-4',6'-dimethoxydihydrochalcone;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 5 Articles be found

Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Cala Peralta, Antonio,Helesbeux, Jean-Jacques,Hoff, Daniel,Hofstetter, Robert Klaus,Jordan, Paul M.,Koeberle, Andreas,Kretzer, Christian,Meyer, Katharina P. L.,Richomme, Pascal,Schuster, Daniela,Seraphin, Denis,Stuppner, Hermann,Temml, Veronika,Viault, Guillaume,Werner, Markus,Werz, Oliver

, (2021/12/24)

Specialized pro-resolving mediators (SPMs) comprise lipid mediators (LMs) produced from polyunsaturated fatty acids (PUFAs) via stereoselective oxygenation particularly involving 12/15-lipoxygenases (LOXs). In contrast to pro-inflammatory LMs such as leuk

Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction

Wei, Yu,Tang, Jinghua,Cong, Xuefeng,Zeng, Xiaoming

supporting information, p. 3165 - 3169 (2013/11/06)

Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.

COMPOUNDS, THEIR SYNTHESES, AND THEIR USES

-

Page/Page column 41, (2010/04/03)

Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones

Aponte, José C.,Verástegui, Manuela,Málaga, Edith,Zimic, Mirko,Quiliano, Miguel,Vaisberg, Abraham J.,Gilman, Robert H.,Hammond, Gerald B.

experimental part, p. 6230 - 6234 (2009/09/25)

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identification of analogues with selective and significant in vitro anti-Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted in the discovery of 2′,4′-diallyloxy- 6′-methoxy chalcones with improved selectivity against this parasite at concentrations below 25 μM, four of which exhibited a selectivity index greater than 12.

Syntheses of Two New Naturally Occurring Dihydrochalkones, Uvangolatin and 2',4'-Dihydroxy-4,6'-dimethoxydihydrochalkone

Bhardwaj, D. K.,Jain, R. K.,Munjal, Anita,Prashar, Meenu

, p. 476 - 477 (2007/10/02)

The structures proposed for the two naturally occurring dihydrochalkones, uvangolatin isolated from Uvaria angolensis as 2',4'-dihydroxy-6'-methoxydihydrochalkone (I) and another dihydrochalkone isolated from Iryanthera laevis as 2',4'-dihydroxy-4,6'-dime

Process route upstream and downstream products

Process route

C<sub>21</sub>H<sub>26</sub>O<sub>7</sub>

C21H26O7

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
With toluene-4-sulfonic acid; In ethanol; dichloromethane; at 60 ℃; for 1h;
75%
With toluene-4-sulfonic acid; In ethanol; dichloromethane; at 60 ℃; for 1h;
75%
(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
56121-44-9

(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1.5h; under 12929 Torr;
40.2%
With hydrogen; palladium on activated charcoal; In ethyl acetate;
0.4 g
2′,4′-dihydroxy-4,6′-dimethoxychalcone
855740-21-5

2′,4′-dihydroxy-4,6′-dimethoxychalcone

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr; Schlenk technique; Sealed tube;
70%
1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one
39548-89-5

1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 1 g / aq. KOH / ethanol / 72 h / Ambient temperature
2: 0.6 g / HCl, acetic acid / 0.5 h / 50 - 60 °C
3: 0.4 g / H2 / Pd/C / ethyl acetate
With hydrogenchloride; potassium hydroxide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol; ethyl acetate;
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 1 g / aq. KOH / ethanol / 72 h / Ambient temperature
2: 0.6 g / HCl, acetic acid / 0.5 h / 50 - 60 °C
3: 0.4 g / H2 / Pd/C / ethyl acetate
With hydrogenchloride; potassium hydroxide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol; ethyl acetate;
2'-hydroxy-4'-benzyloxy-4,6'-dimethoxychalkone
84457-62-5

2'-hydroxy-4'-benzyloxy-4,6'-dimethoxychalkone

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 0.6 g / HCl, acetic acid / 0.5 h / 50 - 60 °C
2: 0.4 g / H2 / Pd/C / ethyl acetate
With hydrogenchloride; hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate;
2,4,6-trihydroxyacetophenone
480-66-0,67471-34-5

2,4,6-trihydroxyacetophenone

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 6 h / 65 °C / Schlenk technique; Sealed tube
2: aluminum (III) chloride / chlorobenzene / 1 h / Reflux; Sealed tube; Schlenk technique
3: ammonium peroxydisulfate / tert-Amyl alcohol / 24 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry
4: 5%-palladium/activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr / Schlenk technique; Sealed tube
With aluminum (III) chloride; ammonium peroxydisulfate; 5%-palladium/activated carbon; hydrogen; potassium carbonate; In tert-Amyl alcohol; ethanol; chlorobenzene; acetone;
4,6-dihydroxy-2-methoxyacetophenone
3602-54-8

4,6-dihydroxy-2-methoxyacetophenone

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: ammonium peroxydisulfate / tert-Amyl alcohol / 24 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry
2: 5%-palladium/activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr / Schlenk technique; Sealed tube
With ammonium peroxydisulfate; 5%-palladium/activated carbon; hydrogen; In tert-Amyl alcohol; ethanol;
2-hydroxy-4,6-dimethoxyacetophenone
90-24-4

2-hydroxy-4,6-dimethoxyacetophenone

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / chlorobenzene / 1 h / Reflux; Sealed tube; Schlenk technique
2: ammonium peroxydisulfate / tert-Amyl alcohol / 24 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry
3: 5%-palladium/activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr / Schlenk technique; Sealed tube
With aluminum (III) chloride; ammonium peroxydisulfate; 5%-palladium/activated carbon; hydrogen; In tert-Amyl alcohol; ethanol; chlorobenzene;
5-methoxyresorcinol
2174-64-3

5-methoxyresorcinol

3-(4-methoxyphenyl)propionitrile
22442-48-4

3-(4-methoxyphenyl)propionitrile

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone
75679-58-2

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Conditions
Conditions Yield
Multistep reaction; (i) ZnCl2, HCl, Et2O, (ii) Et2O;

Global suppliers and manufacturers

Global( 5) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • BioBioPha Co., Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-871-65217109
  • Emails:sales@mail.biobiopha.com
  • Main Products:1
  • Country:China (Mainland)
  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
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