3791-75-1Relevant academic research and scientific papers
New homoisoflavonoid analogues protect cells by regulating autophagy
Gan, Li-She,Zeng, Lin-Wei,Li, Xiang-Rong,Zhou, Chang-Xin,Li, Jie
, p. 1441 - 1445 (2017/03/08)
As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I PI3K signaling pathway.
Synthesis, crystal structure, and biological evaluation of a series of phloretin derivatives
Wang, Li,Li, Zheng-Wei,Zhang, Wei,Xu, Rui,Gao, Fei,Liu, Yang-Feng,Li, Ya-Jun
, p. 16447 - 16457 (2014/12/12)
A one-step synthesis of phloretin derivatives 2-11 from phloretin in good to excellent yields is reported. Their structures were characterized by 1H-NMR, 13C-NMR and MS, and the structures of 8 and 11 were determined by X-ray diffrac
COMPOUNDS, THEIR SYNTHESES, AND THEIR USES
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, (2010/04/03)
Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).
Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora
Yenjai, Chavi,Wanich, Suchana
supporting information; experimental part, p. 2821 - 2823 (2010/08/06)
Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC50 values of 0.014 and 0.23 μM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC50 values of 4.04 and 2.32 μM, respectively.
Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones
Aponte, José C.,Verástegui, Manuela,Málaga, Edith,Zimic, Mirko,Quiliano, Miguel,Vaisberg, Abraham J.,Gilman, Robert H.,Hammond, Gerald B.
experimental part, p. 6230 - 6234 (2009/09/25)
Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identification of analogues with selective and significant in vitro anti-Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted in the discovery of 2′,4′-diallyloxy- 6′-methoxy chalcones with improved selectivity against this parasite at concentrations below 25 μM, four of which exhibited a selectivity index greater than 12.
Pd-C/ammonium formate: A selective catalyst for the hydrogenation of chalcones to dihydrochalcones
Ahmed, Naseem,Van Lier, Johan E.
, p. 584 - 585 (2007/10/03)
Pd-C/ammonium formate is a highly efficient catalyst for the selective hydrogenation of chalcones to dihydrochalcones (DHCs). The reaction proceeds under mild conditions and the Pd-C catalyst is recovered without loss of activity.
A simple and efficient conversion of chalcones to dihydrochalcones
De, Shantanu,Jain, Vimal Niveta,Krishnamurty, H. G.
, p. 163 - 165 (2007/10/02)
The remarcable efficiency of catalytic transfer hydrogenation of chalcones to dihydrochalcones using cyclohexene-Pd/C and ammonium formate-Pd/C is demonstrated.The method is preparatively simple and useful.
Anti-ulcer agent comprising chalcone derivative as effective ingredient and novel chalcone derivative
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, (2008/06/13)
The present invention relates to an anti-ulcer agent comprising a compound represented by the following general formula I as the effective ingredient, and a novel chalcone derivative included in the compound represented by this general formula I: STR1 wherein X and Y independently stand for a hydrogen atom or together form a single bond, R1 stands for a hydroxyl group, an acetoxy group, a carboxymethoxy group or a methoxycarbonylmethoxy group, R2 stands for a hydrogen atom, an isoprenyl group, isopentyl group or a propyl group, R3 stands for hydroxyl group or a methoxy group, R4 stands for a hydrogen atom, a hydroxyl group or a methoxy group, R5 stands for a hydrogen atom, a hydroxyl group, a methoxy group or an isopentyl group, R6 stands for a hydroxyl group, a methoxy group or a carboxymethoxy group, and R7 stands for a hydrogen atom or a methoxy group.
Facile reduction of chalcones to dihydrochalcones with NaBH4/Ni2+ system
Dhawan,Grover
, p. 2405 - 2409 (2007/10/02)
Chalcones have been found to undergo facile reduction on treatment with sodium borohydride-nickel chloride system in dioxan-methanol medium to afford dihydrochalcones.
A highly enantioselective synthesis of (R)- and (S)-5,7-odimethyleucomol
Davis, Franklin A.,Chen, Bang-Chi
, p. 6823 - 6826 (2007/10/02)
Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in>96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxyc
