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Tocopheryl acetate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

7695-91-2

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7695-91-2 Usage

Chemical Properties

Light yellow to yellow clear liquid

Uses

Different sources of media describe the Uses of 7695-91-2 differently. You can refer to the following data:
1. anti-Altzheimer therapeutic
2. vitamin E acetate (tocopherol acetate) is an anti-oxidant with skinmoisturizing activity. given its free-radical scavenging properties, it is useful in uV protective products. Vitamin e acetate is commonly used to replace vitamin e because it is more stable and is converted to vitamin e by the body.
3. Vitamin E (α-tocopherol) occurs naturally in most vegetable oils. The highest concentrations are found in com, soybean oils, sunflower seed, wheat germ, rapeseed, alfalfa, and lettuce. It is claimed to have age-retardant properties. May produce erythemamultiforme-like eruptions. It is used in a number of cosmetic products; creams are used for scars, striae, and bums; in pharmaeeutical ereams and deodorants; as an antioxidant in foods.
4. All-rac-alpha-tocopheryl acetate for peak identification may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

General Description

DL-α-Tocopherol acetate is a stable ester form of vitamin E, widely used in the formulation of cosmetics for the prevention or correction of skin damage.

Hazard

A reproductive hazard.

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.

Purification Methods

It is a viscous liquid which is purified by distillation under high vacuum under N2 or Ar and stored in sealed ampoules in the dark. It is considerably more stable to light and air than the parent unacetylated vitamin. It is insoluble in H2O but freely soluble in organic solvents. All eight stereoisomers have been synthesised. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0.7mm and [] D 20 +3.9o (c 5, EtOH); see above. [Cohen et al. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169.]

Check Digit Verification of cas no

The CAS Registry Mumber 7695-91-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,9 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7695-91:
(6*7)+(5*6)+(4*9)+(3*5)+(2*9)+(1*1)=142
142 % 10 = 2
So 7695-91-2 is a valid CAS Registry Number.
InChI:InChI=1/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23+,31+/m0/s1

7695-91-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (T0252)  DL-α-Tocopherol Acetate  >98.0%(GC)

  • 7695-91-2

  • 25g

  • 325.00CNY

  • Detail
  • TCI America

  • (T0252)  DL-α-Tocopherol Acetate  >98.0%(GC)

  • 7695-91-2

  • 100g

  • 890.00CNY

  • Detail
  • TCI America

  • (T0252)  DL-α-Tocopherol Acetate  >98.0%(GC)

  • 7695-91-2

  • 500g

  • 2,990.00CNY

  • Detail
  • Alfa Aesar

  • (A14505)  Vitamin E acetate, 97%   

  • 7695-91-2

  • 25g

  • 276.0CNY

  • Detail
  • Alfa Aesar

  • (A14505)  Vitamin E acetate, 97%   

  • 7695-91-2

  • 100g

  • 801.0CNY

  • Detail
  • Alfa Aesar

  • (A14505)  Vitamin E acetate, 97%   

  • 7695-91-2

  • 500g

  • 3553.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1030)    pharmaceutical secondary standard; traceable to USP and PhEur

  • 7695-91-2

  • PHR1030-500MG

  • 718.73CNY

  • Detail
  • Sigma-Aldrich

  • (T1600000)  α-Tocopherol acetate  European Pharmacopoeia (EP) Reference Standard

  • 7695-91-2

  • T1600000

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (Y0000384)  All-rac-alpha-tocopherylacetateforpeakidentification  European Pharmacopoeia (EP) Reference Standard

  • 7695-91-2

  • Y0000384

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (29992)  DL-α-Tocopherolacetate  tested according to Ph.Eur.

  • 7695-91-2

  • 29992-50G-F

  • 861.12CNY

  • Detail
  • Supelco

  • (47786)  VitaminEacetate  analytical standard

  • 7695-91-2

  • 000000000000047786

  • 286.65CNY

  • Detail
  • Sigma

  • (T3376)  DL-α-Tocopherolacetate  ≥96% (HPLC)

  • 7695-91-2

  • T3376-5G

  • 299.52CNY

  • Detail

7695-91-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Vitamin E Acetate

1.2 Other means of identification

Product number -
Other names Tocopheryl acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Preservatives and Antioxidants
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7695-91-2 SDS

7695-91-2Relevant articles and documents

SYNTHESIS OF CHROMANOL AND 2-METHYL-1,4-NAPHTHOQUINONE DERIVATIVES

-

Page/Page column 49-50; 61-62; 68-69, (2020/03/05)

The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.

Method for preparing vitamin E acetate

-

Paragraph 0068; 0069; 0070; 0071; 0073, (2019/05/15)

The invention provides a method for preparing vitamin E acetate. The method has the characteristic of high product selectivity; a catalyst used in the method provided by the invention facilitates recovery and reutilization and has less corrosion to equipment; and a product has good stability. The method for preparing the vitamin E acetate provided by the invention prepares the vitamin E acetate through a reaction of 2,3,5-trimethylhydroquinone diester and isophytol, wherein the reaction is carried out in the presence of the catalyst; and with a molecular sieve as a carrier, the catalyst is prepared by loading Bronsted acid, metal halide, metallocene and a metal element onto the molecular sieve.

Vitamin E acetate preparation method (by machine translation)

-

Paragraph 0013, (2019/01/06)

The invention relates to a technical field of chemical synthesis, in particular relates to a vitamin E acetate preparation method, in order to trimethyl [...][...] as raw materials, innovative in a sulfuric acid and paratoluene sulfonic acid under acidic conditions, using magnesium sulfate as a catalyst, greatly improves the catalytic efficiency; in addition, in concentrated hydrochloric acid and ethyl acetate under the reaction environment, esterification synthetic vitamin E acetate efficiency is higher; and, synthetic route of this invention relates to the reaction of the routine chemical reaction, mild reaction conditions, simple operation, is suitable for industrial. (by machine translation)

Method for preparing d1-alpha tocopheryl acetate

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Paragraph 0033; 0034, (2016/11/14)

The invention relates to a method for preparing d1-alpha tocopheryl acetate. According to the method, d1-alpha tocopherol or a mixture of d1-alpha tocopherol and d1-alpha tocopheryl acetate serves as a raw material, nitrogen-containing alkaline matter is adopted as a catalyst, acetic acid or acetic anhydride or a mixture of acetic acid and acetic anhydride serves as an acylating agent, and a d1-alpha tocopheryl acetate product is obtained through an esterification reaction. The preparation method is simple as a whole, operability is good, the yield is high, product quality is good, and besides risks in the aspects of the environment and safety are small.

dl-alpha tocopherol acetate preparation method

-

Paragraph 0040; 0041; 0042; 0043; 0044; 0045, (2016/10/24)

The present invention relates to a dl-alpha tocopherol acetate preparation method, wherein trimethyl hydroquinone diethyl ester or trimethyl hydroquinone-4-ethyl ester is adopted as a raw material, Bronsted acid and Lewis acid are adopted as catalysts, the raw material and phytol or isophytol or a phytol derivative are directly subjected to a condensation reaction in an ester solvent to obtain the product dl-alpha tocopherol acetate or an intermediate dl-alpha tocopherol, wherein the intermediate dl-alpha tocopherol is subjected to further esterification to obtain the product dl-alpha tocopherol acetate. According to the present invention, the process route is simple, the production cost is reduced, the quality of the obtained product is good, the yield is high, and the method is suitable for large-scale industrial production.

ACYLATIONS IN MICRO REACTION SYSTEMS

-

Page/Page column 8-9, (2011/08/04)

A method for acylating tertiary alcohols and phenolic compounds with carboxylic acids or their anhydrides in micro-reaction systems wherein the acylation is effected in the absence of any catalyst including water at residence times of at most 30 minutes.

A Convenient access to (All-rac)-α-tocopherol acetate from linalool and dihydromyrcene

Gembus, Vincent,Sala-Jung, Nathalie,Uguen, Daniel

experimental part, p. 829 - 842 (2009/12/25)

Refluxing trimethylhydroquinone 2 in 10:1 dodecane/CH2Cl 2 with linalool 3b (two-fold excess) and camphorsulfonic acid, then treating the crude condensation product (consisting of a mixture of the chromanols 1b and 1c, alongside the tricyclic compounds 9 and 10) sequentially with Ac2O and m-CPBA afforded, after removal by column chromatography of the 9/10 acetates, a mixture of the regioisomeric epoxides 1jOAc and 1kOAc (ratio 9:1, total 60%). Treatment of this mixture with Al(O-i-Pr)3 followed by CuI-catalysed Wurtz coupling of the acetates of the resulting allylic alcohols with citronellylmagnesium chloride 12a, and finally hydrogenation then provided the title acetate (overall 46% from 2).

PROCESS FOR THE ACYLATION OF ORGANIC HYDROXY COMPOUNDS

-

Page/Page column 6-8, (2008/12/06)

A process for acylating organic hydroxy compounds, characterized in that the acylation is effected in the presence of a metal oxide which does not carry a catalyst and the use of such metal oxides for acylating organic hydroxy compounds.

METHOD OF MAKING PURIFIED ODOR FREE TOCOPHEROL ACETATE

-

Page/Page column 1-2, (2008/12/06)

A process for producing odor free tocopherol acetate is disclosed. This process comprises forming a solution of tocopherol acetate in a suitable solvent, e.g., isopropyl alcohol, subjecting said solution to a sufficient amount of low pressure and heat to remove said solvent and sparging sufficient amount of an inert gas through said solution to remove traces of remaining solvent.

PROCESS FOR THE MANUFACTURE OF TOCOPHERYL ACYLATES

-

Page/Page column 8-9; 11, (2008/06/13)

The present invention relates to a process for the manufacture of a tocopheryl acylate which comprises reacting a tocopherol with an acylating agent in the presence of a solid basic catalyst comprising, an alkali metal and/or alkaline earth metal preferably on a solid carrier and to the use of such catalysts in the acylation of tocopherols.

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