7695-91-2Relevant articles and documents
SYNTHESIS OF CHROMANOL AND 2-METHYL-1,4-NAPHTHOQUINONE DERIVATIVES
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Page/Page column 49-50; 61-62; 68-69, (2020/03/05)
The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.
Method for preparing vitamin E acetate
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Paragraph 0068; 0069; 0070; 0071; 0073, (2019/05/15)
The invention provides a method for preparing vitamin E acetate. The method has the characteristic of high product selectivity; a catalyst used in the method provided by the invention facilitates recovery and reutilization and has less corrosion to equipment; and a product has good stability. The method for preparing the vitamin E acetate provided by the invention prepares the vitamin E acetate through a reaction of 2,3,5-trimethylhydroquinone diester and isophytol, wherein the reaction is carried out in the presence of the catalyst; and with a molecular sieve as a carrier, the catalyst is prepared by loading Bronsted acid, metal halide, metallocene and a metal element onto the molecular sieve.
Vitamin E acetate preparation method (by machine translation)
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Paragraph 0013, (2019/01/06)
The invention relates to a technical field of chemical synthesis, in particular relates to a vitamin E acetate preparation method, in order to trimethyl [...][...] as raw materials, innovative in a sulfuric acid and paratoluene sulfonic acid under acidic conditions, using magnesium sulfate as a catalyst, greatly improves the catalytic efficiency; in addition, in concentrated hydrochloric acid and ethyl acetate under the reaction environment, esterification synthetic vitamin E acetate efficiency is higher; and, synthetic route of this invention relates to the reaction of the routine chemical reaction, mild reaction conditions, simple operation, is suitable for industrial. (by machine translation)
Method for preparing d1-alpha tocopheryl acetate
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Paragraph 0033; 0034, (2016/11/14)
The invention relates to a method for preparing d1-alpha tocopheryl acetate. According to the method, d1-alpha tocopherol or a mixture of d1-alpha tocopherol and d1-alpha tocopheryl acetate serves as a raw material, nitrogen-containing alkaline matter is adopted as a catalyst, acetic acid or acetic anhydride or a mixture of acetic acid and acetic anhydride serves as an acylating agent, and a d1-alpha tocopheryl acetate product is obtained through an esterification reaction. The preparation method is simple as a whole, operability is good, the yield is high, product quality is good, and besides risks in the aspects of the environment and safety are small.
dl-alpha tocopherol acetate preparation method
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Paragraph 0040; 0041; 0042; 0043; 0044; 0045, (2016/10/24)
The present invention relates to a dl-alpha tocopherol acetate preparation method, wherein trimethyl hydroquinone diethyl ester or trimethyl hydroquinone-4-ethyl ester is adopted as a raw material, Bronsted acid and Lewis acid are adopted as catalysts, the raw material and phytol or isophytol or a phytol derivative are directly subjected to a condensation reaction in an ester solvent to obtain the product dl-alpha tocopherol acetate or an intermediate dl-alpha tocopherol, wherein the intermediate dl-alpha tocopherol is subjected to further esterification to obtain the product dl-alpha tocopherol acetate. According to the present invention, the process route is simple, the production cost is reduced, the quality of the obtained product is good, the yield is high, and the method is suitable for large-scale industrial production.
ACYLATIONS IN MICRO REACTION SYSTEMS
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Page/Page column 8-9, (2011/08/04)
A method for acylating tertiary alcohols and phenolic compounds with carboxylic acids or their anhydrides in micro-reaction systems wherein the acylation is effected in the absence of any catalyst including water at residence times of at most 30 minutes.
A Convenient access to (All-rac)-α-tocopherol acetate from linalool and dihydromyrcene
Gembus, Vincent,Sala-Jung, Nathalie,Uguen, Daniel
experimental part, p. 829 - 842 (2009/12/25)
Refluxing trimethylhydroquinone 2 in 10:1 dodecane/CH2Cl 2 with linalool 3b (two-fold excess) and camphorsulfonic acid, then treating the crude condensation product (consisting of a mixture of the chromanols 1b and 1c, alongside the tricyclic compounds 9 and 10) sequentially with Ac2O and m-CPBA afforded, after removal by column chromatography of the 9/10 acetates, a mixture of the regioisomeric epoxides 1jOAc and 1kOAc (ratio 9:1, total 60%). Treatment of this mixture with Al(O-i-Pr)3 followed by CuI-catalysed Wurtz coupling of the acetates of the resulting allylic alcohols with citronellylmagnesium chloride 12a, and finally hydrogenation then provided the title acetate (overall 46% from 2).
PROCESS FOR THE ACYLATION OF ORGANIC HYDROXY COMPOUNDS
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Page/Page column 6-8, (2008/12/06)
A process for acylating organic hydroxy compounds, characterized in that the acylation is effected in the presence of a metal oxide which does not carry a catalyst and the use of such metal oxides for acylating organic hydroxy compounds.
METHOD OF MAKING PURIFIED ODOR FREE TOCOPHEROL ACETATE
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Page/Page column 1-2, (2008/12/06)
A process for producing odor free tocopherol acetate is disclosed. This process comprises forming a solution of tocopherol acetate in a suitable solvent, e.g., isopropyl alcohol, subjecting said solution to a sufficient amount of low pressure and heat to remove said solvent and sparging sufficient amount of an inert gas through said solution to remove traces of remaining solvent.
PROCESS FOR THE MANUFACTURE OF TOCOPHERYL ACYLATES
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Page/Page column 8-9; 11, (2008/06/13)
The present invention relates to a process for the manufacture of a tocopheryl acylate which comprises reacting a tocopherol with an acylating agent in the presence of a solid basic catalyst comprising, an alkali metal and/or alkaline earth metal preferably on a solid carrier and to the use of such catalysts in the acylation of tocopherols.