77385-90-1Relevant articles and documents
Biosynthesis of berninamycin: Incorporation of 13C-labeled amino acids
Lau, Raymond C. M.,Rinehart, Kenneth L.
, p. 7606 - 7610 (1995)
Two-dimensional NMR and FABMS/MS studies agree with the structure for berninamycin A proposed by Abe et al. (Tetrahedron Lett. 1988, 29, 1401-1404). Biosynthetic studies with 13C-enriched amino acids confirm our earlier results that the dehydro
Radical 1,4-Aryl Migration Enabled Remote Cross-Electrophile Coupling of α-Amino-β-Bromo Acid Esters with Aryl Bromides
Chen, Shi-Lu,He, Jin,Hong, Yu,Li, Jin-Heng,Liu, Jian,Liu, Ting,Tang, Shi,Wang, Shuo-Wen,Xu, Zhen-Hua,Yu, Jian
supporting information, p. 21360 - 21367 (2021/08/23)
We report an unprecedented, efficient nickel-catalysed radical relay for the remote cross-electrophile coupling of β-bromo-α-benzylamino acid esters with aryl bromides via 1,4-aryl migration/arylation cascades. β-Bromo-α-benzylamino acid esters are consid
Alpha-substituted-alpha-amino acid ester compound and preparation method thereof
-
Paragraph 0102-0110, (2021/06/09)
The invention discloses an alpha-substituted-alpha-amino acid ester compound and a preparation method thereof. Aromatic amine and alkenyl ether are added into a reactor and dissolved in a solvent, a reaction is carried out under the action of a palladium catalyst, a ligand and an oxidizing agent, separation and purification are carried out, the alpha-substituted-alpha-amino acid ester compound is obtained, and the reaction formula of the preparation method is shown in the formula (I). According to the method, alkenyl ether and aromatic amine which are simple and easy to obtain are used as reaction raw materials to synthesize a series of alpha-substituted-alpha-amino-acid ester compounds, and the method has the advantages that the raw materials are simple and easy to obtain, operation is convenient, conditions are mild, step atom economy is high, substrate applicability is wide, and functional group tolerance is good.
Manganese-catalysed transfer hydrogenation of esters
Oates, Conor L.,Widegren, Magnus B.,Clarke, Matthew L.
supporting information, p. 8635 - 8638 (2020/08/21)
Manganese catalysed ester reduction using ethanol as a hydrogen transfer agent in place of dihydrogen is reported. High yields can be achieved for a range of substrates using 1 mol% of a Mn(i) catalyst, with an alkoxide promoter. The catalyst is derived from a tridentate P,N,N ligand.
Intermediate compound of medicine LB80380 and preparing method and application thereof
-
Paragraph 0190; 0191; 0192; 0193, (2017/05/12)
The invention provides an LB80380 intermediate compound (as shown in formula I in the specification). In the LB80380 intermediate compound, R1, R2, R3 and R4 are chosen from linear chain or branched chain alkyl group, benzyl group which is replaced by one or five R5, or R5CO independently, wherein the R1, the R1, the R3 and the R4 are identical or different; R5 is chosen from hydrogen, C1-C4 alkoxy which is replaced or not replaced, C3-C7 alkenyl alkoxy, or benzyloxy- which is replaced or not replaced. The invention also provides a preparing method and an application of the compound in the formula I. When the compound in formula I is used for preparing a compound (specific chemical formula is in the specification), reaction route raw materials and intermediate materials are low in price and easy to get, cost is low, safety is good, and thus the LB80380 intermediate compound in formula I is applicable to industrial production.
Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA)
-
Page/Page column 126; 127, (2016/06/28)
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
Synthesis, structure-activity, and structure-stability relationships of 2-substituted-n-(4-oxo-3-oxetanyl) n-acylethanolamine acid amidase (NAAA) inhibitors
Vitale, Romina,Ottonello, Giuliana,Petracca, Rita,Bertozzi, Sine Mandrup,Ponzano, Stefano,Armirotti, Andrea,Berteotti, Anna,Dionisi, Mauro,Cavalli, Andrea,Piomelli, Daniele,Bandiera, Tiziano,Bertozzi, Fabio
supporting information, p. 323 - 336 (2014/04/03)
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that preferentially hydrolyzes saturated or monounsaturated fatty acid ethanolamides (FAEs), such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA), which are endogenous agonists of nu
DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA)
-
Paragraph 0366, (2013/06/06)
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
ETHYNYLBENZENE DERIVATIVES
-
Page/Page column 70, (2012/03/26)
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
Copper-catalyzed amination of ketene silyl acetals with hydroxylamines: Electrophilic amination approach to α-amino acids
Matsuda, Naoki,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
supporting information, p. 11827 - 11831 (2013/01/15)
Role reversal: The title reaction has been developed to deliver α-amino acids under very mild reaction conditions (see scheme; dpppen=1,5-bis(diphenylphosphino)pentane). The catalysis provides a new C-N bond-forming approach for the synthesis of α-amino a