789-81-1Relevant articles and documents
Interactions of N′-[1-(2-Hydroxyphenyl)ethylidene]Isonicotinohydrazide, a Hydrazone Schiff Base and Selected Lanthanides: Potentiometric and Spectral Studies
Varam, Yuimi,Rajkumari, Lonibala
, p. 1729 - 1754 (2016)
Abstract: Potentiometric and spectroscopic techniques are used to study the interaction of N′-[1-(2-hydroxyphenyl)ethylidene]Isonicotinohydrazide (HpEH) with trivalent Pr, Nd, Gd, Tb, and Ho ions. Potentiometric titrations, carried out keeping the Ln3+/HpEH molar ratios at 1:2 and 1:4 at different temperature and a constant ionic strength of 0.1?mol·dm?3 KNO3 in aqueous dioxane (40%) medium, show two protons of the ligand in equilibrium and complex formation of 1:1, 1:2 and 1:3 Ln3+/HpEH stoichiometry. The conditional stability constants of the Ln3+–HpEH complexes increase in the order: Pr?3+. Photoluminescence study of the Tb3+ and HpEH complex reveals that HpEH is florescent and has no sensitizing effect on Tb3+ luminescence in ethanol, while in the isolated solid Tb3+–HpEH complex the luminescence intensity was found to be greatly sensitized. The synthesized Tb3+–HpEH complex, characterized on the basis of elemental analysis, magnetic susceptibility, molar conductivity, thermal analysis and spectral measurements is paramagnetic, acts as a 2:1 electrolyte and is of 1:3 Ln3+/HpEH stoichiometry. Graphical Abstract: [Figure not available: see fulltext.]
Biochemical relevance of Cr(III) complexes of isoniazid: synthesis, characterization, DFT, antibacterial screening, antioxidant activity and glucose-lowering effect in STZ-induced diabetic rats
Shukla, Satyendra N.,Gaur, Pratiksha,Jhariya, Sangeeta,Chaurasia, Bhaskar,Vaidya, Preeti,Azam, Mohammad
, p. 664 - 689 (2019/02/14)
Molecular mechanism suggests that the incorporation of an antioxidant organic moiety to chromium will be a sound strategy for the synthesis of safer and more effective hypoglycemic compounds. Two Schiff base ligands were derived by condensation of isonico
Syntheses and structural investigation of some alkali metal ion-mediated LVVO2- (L2- = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities
Dash, Subhashree P.,Panda, Alok K.,Pasayat, Sagarika,Dinda, Rupam,Biswas, Ashis,Tiekink, Edward R. T.,Patil, Yogesh P.,Nethaji,Kaminsky, Werner,Mukhopadhyay, Subhadip,Bhutia, Sujit K.
, p. 10139 - 10156 (2014/06/24)
Eight alkali metal ion-mediated dioxidovanadium(v), [{VVO 2L1-6}A(H2O)n]∝, complexes for A = Li+, Na+, K+ and Cs +, containing tridentate aroylhydrazonate ligands coordinating via ONO donor atoms, are described. All the synthesised ligands and the metal complexes were successfully characterised by elemental analysis, IR, UV-Vis and NMR spectroscopy. X-ray crystallographic investigation of 3, 5-7 shows the presence of distorted NO4 coordination geometries for LVO 2- in each case, and varying μ-oxido and/or μ-aqua bridging with interesting variations correlated with the size of the alkali metal ions: with small Li+, no bridging-O is found but four ion aggregates are found with Na+, chains for K+ and finally, layers for Cs+. Two (5) or three-dimensional (3, 6 and 7) architectures are consolidated by hydrogen bonding. The dioxidovanadium(v) complexes were found to exhibit DNA binding activity due to their interaction with CT-DNA by the groove binding mode, with binding constants ranging from 103 to 104 M-1. Complexes 1-8 were also tested for DNA nuclease activity against pUC19 plasmid DNA which showed that 6 and 7 had the best DNA binding and photonuclease activity; these results support their good protein binding and cleavage activity with binding constants ranging from 104 to 105 M-1. Finally, the in vitro antiproliferative activity of all complexes was assayed against the HeLa cell line. Some of the complexes (2, 5, 6 and 7) show considerable activity compared to commonly used chemotherapeutic drugs. The variation in cytotoxicity of the complexes is influenced by the various functional groups attached to the aroylhydrazone derivative.
