83023-58-9

Basic information

• Product Name: (2S)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE
• Synonyms: (2S)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE;3-((2S)pyrrolidin-2-yl)-5-broMopyridine;Pyridine, 3-broMo-5-(2-pyrrolidinyl)-, (S)-;Pyridine,3-broMo-5-(2S)-2-pyrrolidinyl-;(S)-3-bromo-5-(pyrrolidin-2-yl)pyridine;3-bromo-5-[(2S)-pyrrolidin-2-yl]pyridine;5-Bromonornicotine
• CAS NO: 83023-58-9
• Molecular Formula: C₉H₁₁BrN₂
• Molecular Weight: 227.1
• Mol File: 83023-58-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295.4 °C at 760 mmHg
• Flash Point: 132.5 °C
• Appearance: /
• Density: 1.434 g/cm³
• Vapor Pressure: 0.00153mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: (2S)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE(83023-58-9)
• EPA Substance Registry System: (2S)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE(83023-58-9)

Safety Data

• Hazardous Substances Data: 83023-58-9(Hazardous Substances Data)

Usage

General Description

(2S)-5-Bromo-3-(2-pyrrolidinyl)pyridine is a chemical compound with the molecular formula C10H11BrN2. It is a brominated pyridine derivative with a pyrrolidinyl group attached to the third carbon of the pyridine ring. (2S)-5-BROMO-3-(2-PYRROLIDINYL)PYRIDINE has potential applications in the field of medicinal chemistry and drug development, as it may possess pharmacological properties that could be beneficial for various therapeutic purposes. However, further research is necessary to fully understand its biological activities and potential uses. The specific properties and potential applications of (2S)-5-bromo-3-(2-pyrrolidinyl)pyridine have yet to be fully elucidated, and it remains a subject of interest in the scientific community.

InChI:InChI=1/C9H11BrN2/c10-8-4-7(5-11-6-8)9-2-1-3-12-9/h4-6,9,12H,1-3H2/t9-/m0/s1

Upstream product

• 1005342-85-7 3-Bromo-5-{(S)-1-[(R)-1-(4-methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridine 
• 64319-85-3 3-bromo-5-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 360767-38-0 (R)-methanesulfonic acid 1-(5-bromopyridin-3-yl)but-3-enyl ester 
• 360767-40-4 (R)-1-(5-bromopyridin-3-yl)but-3-en-1-ol 
• 360767-46-0 1-(5-bromopyridin-3-yl)but-3-en-1-one 
• 360767-43-7 1-(5-bromopyridin-3-yl)but-3-en-1-ol 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 360767-36-8 (S)-3-(1-azidobut-3-enyl)-5-bromopyridine 
• 71719-06-7 5-Bromo-3-(2-pyrrolidinyl)pyridine 
• 263888-14-8 (2'S)-N'-[(1R,2S,5R)-Menthoxycarbonyl]-5-bromonornicotine 

Downstream Products

• 1020176-96-8 ((S)-1-{(S)-2-[(S)-2-(5-Bromo-pyridin-3-yl)-pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester 
• 350820-75-6 N-[1-oxo-6-[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]hexyl]-β-alanine phenylmethyl ester 
• 350820-86-9 (2S)-2-(3-pyridinyl)-1-pyrrolidinebutanoic acid phenylmethyl ester 
• 179120-92-4 altinicline 
• 494-97-3 nornicotine 

Relevant articles and documents

Pyrrolydine Derivatives as IAP Inhibitors

The present invention relates to novel IAP inhibitor compounds of: Formula (I).

The first enantioselective synthesis of (S)-5-bromo-3-(1-methyl-2-pyrrolidinyl)pyridine: A key intermediate for the preparation of SIB-1508Y

The first enantioselective synthesis of (S)-5-bromo-3-(1-methyl-2-pyrrolidinyl)pyridine is described via intramolecular hydroboration-cycloalkylation of an azido-olefin intermediate. The chiral homoallylic alcohol was efficiently synthesized by enantioselective reduction of the corresponding ketone using (+)-diisopinocamphenylchloroborane as the key reaction. The total synthesis of (S)-SIB-1508Y was achieved with an enantiomeric excess (e.e.) of 94% in ten steps and in 18% overall yield from the commercially available 5-bromo-3-pyridinecarboxylic acid.

Resolution of (±)-5-bromonornicotine. Synthesis of (R)- and (S)-nornicotine of high enantiomeric purity

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