83434-58-6

Basic information

• Product Name: Di-O-benzoyl-3,5 di-O-acetyl-1,2 α-D-xylofurannose
• Synonyms: Di-O-benzoyl-3,5 di-O-acetyl-1,2 α-D-xylofurannose
• CAS NO: 83434-58-6
• Molecular Weight: 442.422
• Mol File: 83434-58-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Di-O-benzoyl-3,5 di-O-acetyl-1,2 α-D-xylofurannose(CAS DataBase Reference)
• NIST Chemistry Reference: Di-O-benzoyl-3,5 di-O-acetyl-1,2 α-D-xylofurannose(83434-58-6)
• EPA Substance Registry System: Di-O-benzoyl-3,5 di-O-acetyl-1,2 α-D-xylofurannose(83434-58-6)

Safety Data

• Hazardous Substances Data: 83434-58-6(Hazardous Substances Data)

Upstream product

• 6893-67-0 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose 
• 108-24-7 acetic anhydride 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 

Downstream Products

• 107299-84-3 1-(2'-O-acetyl-3',5'-di-O-benzoyl-β-D-xylofuranosyl)cytosine 
• 99355-31-4 C₂₅H₂₂N₂O₉ 
• 107271-89-6 N²-acetyl-9-(3',5'-di-O-benzoyl-β-D-xylofuranosyl)guanine 
• 83373-05-1 Di-O-benzoyl-3',5' O-acetyl-2' β-xylofurannosyl-9 adenine 

Relevant articles and documents

2-Substituted thiazole-4-carboxamide derivatives as tiazofurin mimics: Synthesis and in vitro antitumour activity

Tiazofurin analogues bearing a 5-hydroxymethyl-2-methyl-tetrahydrofuro[2,3- d][1,3]dioxol-6-ol moiety as a sugar mimic (2 and 3), and two novel thiazole-based acyclo-C-nucleosides 4 and 16 have been synthesized in multistep sequences starting from d-xylose (compounds 2 and 3) or from d-arabinose (compounds 4 and 16). All synthesized analogues showed potent in vitro antitumour activities against a panel of human tumour cell lines. Flow cytometry data suggest that cytotoxic effects of analogues 2-4 and 16 in the culture of K562 cells might be mediated by apoptosis. It was also found that these analogues induced changes in cell cycle distribution of K562 cells. Results of western blot analysis (upregulation of Bax and downregulation of Bcl-2, activation of caspase-3 and the presence of a PARP cleavage product) suggest that tiazofurin mimics (2-4 and 16) in K562 cells induced apoptosis in a caspase-dependent way.