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1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose is a complex organic compound derived from α-D-xylofuranose, a monosaccharide. 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose is characterized by the presence of an isopropylidene group at the 1,2-positions, which protects the hydroxyl groups at these positions, and benzoyl groups at the 3,5-positions, which protect the hydroxyl groups at these positions as well. The isopropylidene and benzoyl groups are commonly used in carbohydrate chemistry to protect specific functional groups during chemical reactions, preventing unwanted side reactions and facilitating the synthesis of more complex molecules. 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose is often used as an intermediate in the synthesis of various oligosaccharides and polysaccharides, as well as in the study of carbohydrate chemistry and biochemistry.

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  • 6893-67-0 Structure
  • Basic information

    1. Product Name: 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose
    2. Synonyms: 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose
    3. CAS NO:6893-67-0
    4. Molecular Formula:
    5. Molecular Weight: 398.412
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 6893-67-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose(6893-67-0)
    11. EPA Substance Registry System: 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose(6893-67-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6893-67-0(Hazardous Substances Data)

6893-67-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6893-67-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,9 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6893-67:
(6*6)+(5*8)+(4*9)+(3*3)+(2*6)+(1*7)=140
140 % 10 = 0
So 6893-67-0 is a valid CAS Registry Number.

6893-67-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose

1.2 Other means of identification

Product number -
Other names 3,5-di-O-benzoyl-1,2-O-isopropylidene-α-D-xylofuranose

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6893-67-0 SDS

6893-67-0Relevant articles and documents

3-(Dimethylamino)-1-propylamine: A cheap and versatile reagent for removal of byproducts in carbohydrate chemistry

Andersen, Sofie Meng,Heuckendorff, Mads,Jensen, Henrik H.

supporting information, p. 944 - 947 (2015/04/14)

Inexpensive 3-(dimethylamino)-1-propylamine (DMAPA) was found to be effective in anomeric deacylation reactions giving 1-O deprotected sugars in high yield as precursors for the formation of imidate glycosyl donors. DMAPA was also found to be useful for removing excess reagents such as benzoyl chloride, tosyl chloride, and 2,2,2-trifluoro-N-phenylacetimidoyl chloride. The deacylation reaction could be conducted in moist THF and did not require chromatographic purification since an acidic wash was sufficient to remove excess reagent and the formed byproduct.

2-Substituted thiazole-4-carboxamide derivatives as tiazofurin mimics: Synthesis and in vitro antitumour activity

Popsavin, Mirjana,Koji?, Vesna,Spai?, Sa?a,Svir?ev, Milo?,Bogdanovi?, Gordana,Jakimov, Dimitar,Aleksi?, Lidija,Popsavin, Velimir

, p. 2343 - 2350 (2014/04/03)

Tiazofurin analogues bearing a 5-hydroxymethyl-2-methyl-tetrahydrofuro[2,3- d][1,3]dioxol-6-ol moiety as a sugar mimic (2 and 3), and two novel thiazole-based acyclo-C-nucleosides 4 and 16 have been synthesized in multistep sequences starting from d-xylose (compounds 2 and 3) or from d-arabinose (compounds 4 and 16). All synthesized analogues showed potent in vitro antitumour activities against a panel of human tumour cell lines. Flow cytometry data suggest that cytotoxic effects of analogues 2-4 and 16 in the culture of K562 cells might be mediated by apoptosis. It was also found that these analogues induced changes in cell cycle distribution of K562 cells. Results of western blot analysis (upregulation of Bax and downregulation of Bcl-2, activation of caspase-3 and the presence of a PARP cleavage product) suggest that tiazofurin mimics (2-4 and 16) in K562 cells induced apoptosis in a caspase-dependent way.

Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl) thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic

Popsavin, Mirjana,Spai?, Sa?a,Svir?ev, Milo?,Koji?, Vesna,Bogdanovi?, Gordana,Popsavin, Velimir

, p. 6700 - 6704 (2013/01/14)

2-(β-d-xylofuranosyl)thiazole-4-carboxamide (2) and two new tiazofurin analogues with 5-hydroxymethyl-2-methyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol moiety as a sugar mimic (27 and 28) have been synthesized and evaluated for their in vitro antitumour activity against a panel of human tumour cell lines (K562, HL 60, Jurkat, Raji and HeLa). In contrast to previous literature reports, a metabolic MTT assay revealed remarkable cytotoxicity of 2 against K562 (IC50 = 0.15 μM) and HL-60 (IC50 = 0.13 μM) cells. Flow cytometry data suggest that cytotoxic effects of analogue 2 in the culture of K562 cells might be mediated by apoptosis, in opposite to tiazofurin, which did not induce apoptosis of K562 cells after 24 h, thus suggesting a different mechanism of action. All three analogues 2, 27 and 28 were also active against Jurkat, Raji and HeLa cells, with IC50 values in the range from 0.06 to 5.61 μM, but were completely inactive against the normal foetal lung fibroblasts (MRC-5).

Synthesis and comparative evaluation of two antiviral agents: β-L- Fd4C and β-D-Fd4C

Chen, Shu-Hui,Lin, Stanley,King, Ivan,Spinka, Tracy,Dutschman, Ginger E.,Gullen, Elizabeth A.,Cheng, Yung-Chi,Doyle, Terrence W.

, p. 3245 - 3250 (2007/10/03)

The synthesis of β-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of β-D-Fd4C was compared with that of β-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, β-L-Fd4C was found to be the most potent antiviral agent.

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