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83537-94-4

83537-94-4

83537-94-4

Identification

Synonyms:

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Chemical Properties

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 9 Articles be found

Helical Peptides Design for Molecular Dipoles Functionalization of Wide Band Gap Oxides

Bartynski, Robert A.,Chen, Yuan,Galoppini, Elena,Harmer, Ryan,Rangan, Sylvie,Viereck, Jonathan

supporting information, p. 3489 - 3498 (2020/03/06)

The use of helical hexapeptides to establish a surface dipole layer on a TiO2 substrate, with the goal of influencing the energy levels of a coadsorbed chromophore, is explored. Two helical hexapeptides, synthesized from 2-amino isobutyric acid

Deracemization and the first CD spectrum of a 310-helical peptide made of achiral α-amino-isobutyric acid residues in a chiral membrane mimetic environment

Ceccacci, Francesca,Mancini, Giovanna,Rossi, Paola,Scrimin, Paolo,Sorrenti, Alessandro,Tecilla, Paolo

, p. 10133 - 10135 (2013/10/22)

Interaction of the racemic helical homo-octapeptide made by the achiral Cα-methyl alanine (Aib) amino acid with a chiral enantiopure micellar aggregate made of N-dodecylproline led to the deracemization of the helical Aib sequence thus allowing

Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy

Kouodom, Morelle Negom,Boscutti, Giulia,Celegato, Marta,Crisma, Marco,Sitran, Sergio,Aldinucci, Donatella,Formaggio, Fernando,Ronconi, Luca,Fregona, Dolores

, p. 248 - 260 (2013/01/15)

As a further extension of our research work focusing on the development of gold(III)-dithiocarbamato dtc derivatives of oligopeptides as potential anticancer agents, complexes [AuIIIX2(dtc-Sar-l-Ser(t-Bu)- O(t-Bu))] (X = Br (1a)/Cl (

Process route upstream and downstream products

Process route

Z-Aib-OH
15030-72-5

Z-Aib-OH

H-Aib-OtBu
4512-32-7

H-Aib-OtBu

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
Z-Aib-OH; With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.333333h; Inert atmosphere;
H-Aib-OtBu; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
87%
With TEA; dicyclohexyl-carbodiimide; In dichloromethane;
63%
benzyloxycarbonyl-α-aminoisobutyric acid tert-butyl ester
4512-31-6

benzyloxycarbonyl-α-aminoisobutyric acid tert-butyl ester

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 75 percent / H2 / Pd/C / methanol
2: 63 percent / TEA, DCC / CH2Cl2
With TEA; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
Multi-step reaction with 2 steps
1: H2
2: 75 percent / toluene / 1) 4h, 60 deg C, 2) 16h, room temp.
With hydrogen; In toluene;
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / dichloromethane
2: 4-methyl-morpholine / water; tetrahydrofuran / 48 h / 20 °C
With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; dichloromethane; water;
Multi-step reaction with 2 steps
1: hydrogen; 5%-palladium/activated carbon / dichloromethane / 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 72 h / 20 °C
With 5%-palladium/activated carbon; hydrogen; triethylamine; In dichloromethane;
H-Aib-OtBu
4512-32-7

H-Aib-OtBu

Z-Aib-oPiv
15030-73-6

Z-Aib-oPiv

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
84%
In toluene; 1) 4h, 60 deg C, 2) 16h, room temp.;
75%
(Z)-N-(2-(((benzyloxy)carbonyl)amino)-2-methylpropylidene)-1-(tert-butoxy)-2-methyl-1-oxopropan-2-amine oxide
1432584-87-6

(Z)-N-(2-(((benzyloxy)carbonyl)amino)-2-methylpropylidene)-1-(tert-butoxy)-2-methyl-1-oxopropan-2-amine oxide

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
In acetonitrile; at 40 ℃; for 1h; Inert atmosphere; UV-irradiation;
53%
H-Aib-OtBu
4512-32-7

H-Aib-OtBu

(Z-Aib)2O
15030-74-7

(Z-Aib)2O

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
With 4-methyl-morpholine; In tetrahydrofuran; water; at 20 ℃; for 48h;
H-Aib-OtBu
4512-32-7

H-Aib-OtBu

Z-Aib-OBt
154561-22-5

Z-Aib-OBt

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 20 ℃; for 72h;
6.3 g
benzyl chloroformate
501-53-1,94274-21-2

benzyl chloroformate

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 85 percent / H2O; acetone
2: 63 percent / TEA, DCC / CH2Cl2
With TEA; dicyclohexyl-carbodiimide; In dichloromethane; water; acetone;
Z-Aib-OH
15030-72-5

Z-Aib-OH

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / water; dichloromethane / 4 h / 20 °C
2: 4-methyl-morpholine / water; tetrahydrofuran / 48 h / 20 °C
With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; water;
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2: triethylamine / dichloromethane / 72 h / 20 °C
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
H-Aib-OtBu
4512-32-7

H-Aib-OtBu

benzyl carbonochloridate
39608-52-1

benzyl carbonochloridate

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 60 ℃; for 0.5h; Microwave irradiation;
2-amino-isobutyric acid tert-butyl ester hydrochloride
84758-81-6

2-amino-isobutyric acid tert-butyl ester hydrochloride

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester
83537-94-4

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Conditions
Conditions Yield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
3: hydroxylamine hydrochloride / methanol / 60 °C / Inert atmosphere
4: dichloromethane; methanol; diethyl ether / Inert atmosphere; Cooling
5: N-ethyl-N,N-diisopropylamine / benzene / Inert atmosphere; Reflux
6: acetonitrile / 1 h / 40 °C / Inert atmosphere; UV-irradiation
With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane; acetonitrile; benzene;

83537-94-4 Upstream products

83537-94-4 Downstream products

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