855836-62-3

Basic information

• Product Name: 2-BROMO-3-CHLOROPHENOL
• Synonyms: 2-BROMO-3-CHLOROPHENOL;Phenol, 2-broMo-3-chloro-
• CAS NO: 855836-62-3
• Molecular Formula: C₆H₄BrClO
• Molecular Weight: 207.45
• Product Categories: pharmacetical
• Mol File: 855836-62-3.mol

Chemical Properties

• Melting Point: 55.5 °C
• Boiling Point: 233.0±20.0 °C(Predicted)
• Appearance: /
• Density: 1.788±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.47±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-3-CHLOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-CHLOROPHENOL(855836-62-3)
• EPA Substance Registry System: 2-BROMO-3-CHLOROPHENOL(855836-62-3)

Safety Data

• Hazardous Substances Data: 855836-62-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Production:
2-Bromo-3-chlorophenol is utilized as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Dye Industry:
2-BROMO-3-CHLOROPHENOL serves as a key ingredient in the production of dyes, playing a crucial role in the coloration of textiles and other materials.
Used in Insecticide Formulation:
2-Bromo-3-chlorophenol is employed in the formulation of insecticides, leveraging its properties to control and eliminate pests.
Used as a Disinfectant and Antiseptic:
Due to its antimicrobial properties, 2-Bromo-3-chlorophenol is used in disinfectants and antiseptics to prevent the spread of infections and maintain hygiene in various settings.

Upstream product

• 108-43-0 3-monochlorophenol 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 863870-78-4 O-2-bromo-3-chlorophenyl N,N-diethylcarbamate 

Downstream Products

• 872274-09-4 3-bromo-4-chloro-2-hydroxybenzaldehyde 
• 96558-73-5 2-bromo-3-chloro-aniline 
• 1287791-76-7 N-(2-bromo-3-chlorophenyl)-2-hydroxy-2-methylpropanamide 
• 1287791-67-6 2-(2-bromo-3-chlorophenoxy)-2-methylpropanamide 
• 174913-08-7 2-bromo-3-chloro-anisole 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Regioselective monobromination of substituted phenols in the presence of β-cyclodextrin

Cyclodextrin acts as a restricting nanovessel to enhance regioselectivity in bromination of substituted phenols such as 3-nitrophenol, 2-chlorophenol, 3-chlorophenol, and 4-chlorophenol. In contrast to solution bromination, cyclodextrin facilitates regioselective monobromination and formation of polybrominated products are substantially reduced. Selectivities in brominations are also observed in water and in the solid state. The observed results are rationalized on the basis of specific modes of inclusion of substituted phenols inside the cyclodextrin cavity and find strong support from energy minimization studies and 1H-1H NOESY.

A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols

Tandem Sonogashira coupling/5-endo-dig cyclization reactions on 2,3-dihalophenols suppose a straightforward entry to 4-halobenzo[b]furans, which can be easily transformed into 4-functionalized benzo[b]furans, that are difficult to synthesize by other proc