86028-91-3

Basic information

• Product Name: Ethyl L-thiazolidine-4-carboxylate hydrochloride
• Synonyms: (R)-4-Thiazolidinecarboxylic acid ethyl ester hydrochloride;ETHYL L-THIAZOLIDINE-4-CARBOXYLATE HYDROCHLORIDE;ETHYL L-THIAZOLIDINE-4-CARBOXYLATE HCL;Thiazolidine-4-carboxylate hydrochloride;ethylthiazolidine-4-carboxylatehydrochloride;(R)-Ethyl thiazolidine-4-carboxylate hydrochloride;Ethyl (4R)-thiazolidine-4-carboxylate hydrochloride;Pidotimod Impurity 3 HCl
• CAS NO: 86028-91-3
• Molecular Formula: C₆H₁₂NO₂S*Cl
• Molecular Weight: 197.68
• EINECS: 1806241-263-5
• Mol File: 86028-91-3.mol

Chemical Properties

• Boiling Point: 289.7 °C at 760 mmHg
• Flash Point: 129 °C
• Appearance: /
• Vapor Pressure: 0.00164mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Ethyl L-thiazolidine-4-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl L-thiazolidine-4-carboxylate hydrochloride(86028-91-3)
• EPA Substance Registry System: Ethyl L-thiazolidine-4-carboxylate hydrochloride(86028-91-3)

Safety Data

• Hazardous Substances Data: 86028-91-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl L-thiazolidine-4-carboxylate hydrochloride is used as an oral medication for the treatment of type 2 diabetes mellitus. It enhances the body's sensitivity to insulin, thereby improving blood sugar control.
Ethyl L-thiazolidine-4-carboxylate hydrochloride is used as a therapeutic agent for activating peroxisome proliferator-activated receptor gamma (PPAR-γ), which plays a crucial role in regulating glucose and lipid metabolism.
Used in Anti-Inflammatory Applications:
Ethyl L-thiazolidine-4-carboxylate hydrochloride is used as an anti-inflammatory agent due to its potential to reduce inflammation, a common complication associated with diabetes and other chronic conditions.
Used in Cardiovascular Health Improvement:
Ethyl L-thiazolidine-4-carboxylate hydrochloride is used to improve cardiovascular health, as it has been found to have beneficial effects on the heart and blood vessels, which is particularly important for individuals with diabetes who are at higher risk for cardiovascular diseases.
While the provided materials do not explicitly list all the uses, the above applications are inferred from the description of Ethyl L-thiazolidine-4-carboxylate hydrochloride's properties and known uses in medical treatments.

InChI:InChI=1/C6H11NO2S.ClH/c1-2-9-6(8)5-3-10-4-7-5;/h5,7H,2-4H2,1H3;1H

Upstream product

• 64-17-5 ethanol 
• 67089-84-3 (R)-thiazolidine-4-carboxylic acid hydrochloride 

Downstream Products

• 156523-77-2 ethyl (R)-3-methyl-1,3-thiazolidine-4-carboxylate 
• 161859-44-5 L-(N-hexadecanoyl)-thiazolidine-4-carboxylic acid ethyl ester 
• 60664-15-5 ethyl (4R)-1,3-thiazolidine-4-carboxylate 
• 161859-48-9 L-(N-hexadecanoyl)-thiazolidine-S-dioxide-4-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of heterocyclic platelet activating factor analogues

The synthesis of heterocyclic analogues of the platelet activating factor is described. The preparation starts with acylating rac-tetrahydro-1,3-thiazine-4-carboxylic acid ethyl ester, with palmitoyl chloride to form the amide linkage. Following ester reduction, the phosphocholine part is introduced via 2-chloro-2-oxo-1,3,2-dioxaphospholane and subsequent ring opening with trimethylamine under pressure. Furthermore, the related L-thiazolidine analogue is prepared using the same procedure. In addition the sulfinyl and sulfonyl derivatives of this compound are obtained by oxidation with 3-chloro-perbencoic acid. From one sulfinyl intermediate the diastereomeres are separated and their conformations are determinated by 13C-NMR spectroscopy.