86060-94-8 Usage
Uses
Used in Peptide Synthesis:
FMOC-MET-OPFP is utilized as a protecting agent for the amine group of methionine residues during peptide synthesis. Its role is crucial for preventing unwanted side reactions and ensuring the correct formation of peptide bonds, leading to the accurate assembly of the desired peptide sequence.
Used in Protein Modification:
In the field of protein engineering, FMOC-MET-OPFP serves as a modifying agent, allowing for the targeted alteration of protein structures. The introduction of the OPFP group enables the creation of crosslinking functionalities within peptides, which can be instrumental in stabilizing protein conformations or creating novel protein-protein interactions.
Used in Pharmaceutical Development:
FMOC-MET-OPFP is employed as a key component in the design of therapeutic peptides. Its ability to protect and modify peptide structures makes it a valuable asset in the development of new drugs with specific targeting or therapeutic properties.
Used in Research Applications:
In academic and research settings, FMOC-MET-OPFP is used as an experimental tool to probe the structure-function relationships of peptides and proteins. Its versatility in peptide synthesis and modification allows researchers to investigate the effects of different peptide sequences and structures on biological activity and interactions.
Used in Bioconjugation Chemistry:
FMOC-MET-OPFP is applied as a bioconjugation handle, facilitating the attachment of peptides to various biomolecules, surfaces, or nanoparticles. This capability is essential for the development of bioconjugates with applications in drug delivery, imaging, and biosensing.
Check Digit Verification of cas no
The CAS Registry Mumber 86060-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,0,6 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 86060-94:
(7*8)+(6*6)+(5*0)+(4*6)+(3*0)+(2*9)+(1*4)=138
138 % 10 = 8
So 86060-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C26H20F5NO4S/c1-37-11-10-18(25(33)36-24-22(30)20(28)19(27)21(29)23(24)31)32-26(34)35-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,32,34)/t18-/m0/s1
86060-94-8Relevant articles and documents
Synthesis of aryl esters of protected amino acids from aryl sulfonates
Pudhom, Khanitha,Vilaivan, Tirayut
, p. 5939 - 5942 (2007/10/03)
Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.
A new facile one-pot preparation of pentafluorophenyl (Pfp) and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl (Dhbt) esters of Fmoc amino acids
Jacobsen, Mogens Havsteen,Buchardt, Ole,Engdahl, Tom,Holm, Arne
, p. 6199 - 6202 (2007/10/02)
A new one-pot procedure for the preparation of pentafluorophenyl and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl esters of Nα-9-fluorenylmethyloxycarbonyl amino acids bearing no side chain protecting groups is described. The method gives the desired activated esters in high yield and purity without use of the highly allergenic DCC.
9-Fluorenylmethyl Pentafluorophenyl Carbonate as a Useful Reagent for the Preparation of N-9-Fluorenylmethyloxycarbonylamino Acids and their Pentafluorophenyl Esters
Schoen, Istvan,Kisfaludy, Lajos
, p. 303 - 305 (2007/10/02)
9-Fluorenylmethyl pentafluorophenyl carbonate is a useful reagent for the efficient, side reaction-free introduction of N-9-fluorenylmethyloxycarbonyl protecting group into amino acids and for the subsequent preparation of their pentafluorophenyl esters.Some new compounds of both types are described.
