86118-11-8

Basic information

• Product Name: (R)-2-Amino-3-methoxylpropanoic acid
• Synonyms: (R)-2-amino-3-methoxylpropanoic acid Hydrochlorate;(R)-2-amino-3-methoxypropanoic acid O-Methyl-D-serine;D-O-methylserine Hydrochlorate;(R)-2-Amino-3-methoxylpropanoic acid;D-O-Methylserine;H-D-Ser(Me)-OH;O-Methyl-D-serine, (S)-2-Amino-3-methoxypropanoic acid;D-Serine, O-methyl-
• CAS NO: 86118-11-8
• Molecular Formula: C₄H₉NO₃
• Molecular Weight: 119.12
• Product Categories: API;unnatural amino acids;Amino Acid Derivatives;Serine [Ser, S]
• Mol File: 86118-11-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 260.6oC at 760 mmHg
• Flash Point: 111.4oC
• Appearance: /
• Density: 1.195g/cm3
• Vapor Pressure: 0.00363mmHg at 25°C
• Refractive Index: 1.462
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.10±0.10(Predicted)
• CAS DataBase Reference: (R)-2-Amino-3-methoxylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Amino-3-methoxylpropanoic acid(86118-11-8)
• EPA Substance Registry System: (R)-2-Amino-3-methoxylpropanoic acid(86118-11-8)

Safety Data

• Hazardous Substances Data: 86118-11-8(Hazardous Substances Data)

Usage

General Description

(R)-2-Amino-3-methoxypropanoic acid is a chemical compound with the molecular formula C5H11NO3. It is a derivative of the amino acid alanine, with an additional methyl group and a methoxy group attached to the alpha carbon. It is a chiral molecule, with a (R) configuration at the alpha carbon. (R)-2-Amino-3-methoxylpropanoic acid has potential pharmaceutical applications and is being studied for its potential as a drug for the treatment of various conditions. Its precise biological and chemical properties are still under investigation, but its unique structure and potential medicinal properties make it a subject of ongoing research in the field of medicinal chemistry.

InChI:InChI=1/C4H9NO3/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1

Upstream product

• 51293-45-9 O-methyl-N,N-phthaloyl-L-serine 
• 124-41-4 sodium methylate 
• 4219-94-7 DL-3-methoxy-alanine 
• 98632-99-6 O-Methyl-N-acetyl-DL-serine 
• 98026-05-2 α-amino-β-methoxy-propionamide 
• 104160-38-5 O-methyl-D-serine benzyl ester 
• 19794-53-7 3-methoxy-2-aminopropionic acid 
• 1268813-05-3 mirabamide G 
• 1268813-06-4 mirabamide H 
• 1268813-04-2 mirabamide F 
• 1268813-03-1 mirabamide E 
• 86096-35-7 (R)-2-N-(BENZYLOXYCARBONYL)AMINO-3-METHOXYPROPIONIC ACID 
• 1356449-88-1 calyxamide B 
• 1356449-87-0 calyxamide A 

Downstream Products

• 86096-33-5 N-Chloroacetyl-dl-O-methylserine 
• 175481-36-4 lacosamide 
• 196601-67-9 (R)-2-N-acetamido-3-methoxypropionic acid 
• 159610-93-2 Fmoc-O-methyl-L-serine 
• 196601-69-1 (R)-2-amino-N-benzyl-3-methoxypropanamide 
• 474534-78-6 (S)-N-benzyl-2-amino-3-methoxypropionamide 
• 327051-11-6 O-methyl-L-serine methyl ester hydrochloride 
• 1800300-79-1 methyl (2R)-2-amino-3-methoxypropanoate hydrochloride 
• 121470-74-4 N-benzoyl-DL-O-methylserine 
• 51293-47-1 N-tert-butoxycarbonyl-(S)-O-methyl-serin 
• 56-45-1 L-serin 
• 148278-96-0 (R)-2-amino-3-methoxy-propan-1-ol 

Relevant articles and documents

Synthesis method of O-methyl-D-serine

The invention discloses a synthesis method of O-methyl-D-serine. The synthesis method includes the following steps that 1, acrylic acid methyl ester is added into a reaction bottle, after the temperature is raised, bromine is dropwise added, after an addition reaction is conducted, decompression and distillation are conducted to remove excessive bromine, methyl alcohol is added to residues, after the temperature is lowered, sodium methylate is added, after an alcoholysis reaction, decompression and distillation are conducted to remove methyl alcohol, ammonium hydroxide is added, after an ammonium hydroxide, concentrated crystallization is conducted, and O-methyl-DL-serine is obtained; 2, acetic acid is added into the reaction bottle, the O-methyl-DL-serine, D-tartaric acid and salicylaldehyde are added in sequence, after the temperature is raised for a reaction, cooling and crystallization are conducted, separation is conducted, and O-methyl-D-serine double salt is obtained; 3, the O-methyl-D-serine double salt is dissolved in a methyl alcohol aqueous solution, ammonium hydroxide is added to regulate PH to be 7-8, crystallization and separation are conducted, and the O-methyl-D-serine is obtained. The synthesis method is mild in reaction temperature, safe to operate, low in cost and high in chirality purity, and raw materials are easy to obtain.

Marine Cyanobacterial Fatty Acid Amides Acting on Cannabinoid Receptors

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PROCESS FOR PREPARING LACOSAMIDE

The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.