87414-44-6

Basic information

• Product Name: 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester
• Synonyms: 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester;2,5-Dihydro-2-(4-hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2-furancarboxylic acid methyl ester;2,5-Dihydro-4-hydroxy-2-(4-hydroxybenzyl)-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;Butyrolactone II
• CAS NO: 87414-44-6
• Molecular Formula: C₁₉H₁₆O₇
• Molecular Weight: 356.32614
• Product Categories: Antibiotic
• Mol File: 87414-44-6.mol

Chemical Properties

• Melting Point: 91-94 °C
• Boiling Point: 640.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.497±0.06 g/cm3(Predicted)
• PKA: 8.61±0.40(Predicted)
• CAS DataBase Reference: 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester(87414-44-6)
• EPA Substance Registry System: 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester(87414-44-6)

Safety Data

• Hazardous Substances Data: 87414-44-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester is used as a pharmaceutical agent for its potential therapeutic effects. The presence of multiple hydroxyl groups allows for hydrogen bonding and interactions with biological targets, making it a candidate for the development of new drugs with diverse applications.
Used in Cosmetic Industry:
In the cosmetic industry, 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester is used as an antioxidant and free radical scavenger. Its ability to neutralize reactive oxygen species and protect against oxidative stress makes it a valuable ingredient in skincare products, promoting skin health and preventing premature aging.
Used in Food Industry:
2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester is used as a natural preservative in the food industry. Its antioxidant properties help to extend the shelf life of food products by preventing oxidation and spoilage, ensuring freshness and quality.
Used in Research Applications:
In research settings, 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester serves as a valuable compound for studying the structure-activity relationships of various biologically active molecules. Its unique structure and functional groups provide insights into the design and synthesis of new compounds with improved properties and applications.
Overall, 2-(4-Hydroxybenzyl)-3-(4-hydroxyphenyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester is a multifaceted compound with a wide range of potential applications across different industries, from pharmaceuticals and cosmetics to food preservation and research. Its unique structure and properties make it a promising candidate for further development and utilization in various fields.

Upstream product

• 154722-74-4 methyl 2-oxo-3-(4-hydroxyphenyl)propionate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 80171-33-1 5-(4-hydroxybenzylidene)imidazolidine-2,4-dione 
• 156-39-8 4-hydroxyphenylpiruvic acid 
• 10589-28-3 2-hydroxy-3-(4-hydroxyphenyl)-2-propenoic acid 
• 87414-48-0 butyrolactone IIa 

Downstream Products

• 1003192-83-3 2-(4-hydroxyphenyl)ethyl 4-hydroxy-2-(4-hydroxybenzyl)-3-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate 
• 87414-45-7 butyrolactone III 
• 87436-34-8 3-Hydroxy-4-(4-hydroxy-phenyl)-5-(2-isopropyl-benzofuran-5-ylmethyl)-5H-furan-2-one 
• 87414-48-0 butyrolactone IIa 
• 87414-46-8 4-(4-hydroxyphenyl)-5-(4-hydroxyphenylmethyl)-3-hydroxyfurane-2-one 
• 65372-42-1 Butyrolactone I 

Relevant articles and documents

Butenolide derivative as well as preparation method and application thereof

The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.

Furanone compound and preparation method and application thereof

The invention discloses a furanone compound and a preparation method and application thereof. P-hydroxybenzaldehyde is used as a raw material, condensed with hydantoin and then subjected to alkaline hydrolysis and esterification to obtain a p-hydroxyphenylpyruvate intermediate; p-hydroxy benzaldehyde and halogenated isopentene are subjected to alkylation, and then benzyl protection is performed toobtain a benzaldehyde derivative intermediate; a benzaldehyde derivative intermediate and a phenylpyruvate intermediate are subjected to aldol condensation and intramolecular esterification under thecatalysis of a condensing agent to synthesize novel furanone compounds BL5 and BL10. The furanone derivative has H1N1 virus inhibition activity, and can be used for preparing medicines for treating H1N1 virus infection.

Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2.

A series of analogues of butyrolactone I, a natural product isolated from Aspergillus terreus that selectively inhibits the CDK2 and CDK1 kinases and that has been found to exhibit an interesting antiproliferative activity, have been synthesized. Its anti