154722-74-4

Upstream product

• 156-39-8 4-hydroxyphenylpiruvic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 80171-33-1 5-(4-hydroxybenzylidene)imidazolidine-2,4-dione 
• 123-08-0 4-hydroxy-benzaldehyde 
• 10589-28-3 2-hydroxy-3-(4-hydroxyphenyl)-2-propenoic acid 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 

Downstream Products

• 51095-47-7 methyl 3-(4-hydroxyphenyl)-2-hydroxypropionate 
• 87414-44-6 α-oxo-β-(p-hydroxyphenyl)-γ-(p-hydroxybenzyl)-γ-methoxycarbonyl-γ-lactone 
• 240405-23-6 dimethyl (E)-(4-hydroxybenzyl)maleate 
• 240405-25-8 dimethyl (Z)-(4-hydroxybenzyl)maleate 
• 473401-85-3 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester 
• 65372-42-1 Butyrolactone I 
• 87414-46-8 4-(4-hydroxyphenyl)-5-(4-hydroxyphenylmethyl)-3-hydroxyfurane-2-one 
• 87436-34-8 3-Hydroxy-4-(4-hydroxy-phenyl)-5-(2-isopropyl-benzofuran-5-ylmethyl)-5H-furan-2-one 
• 87414-45-7 butyrolactone III 
• 128437-99-0 (4-Benzyloxy)pyruvic Acid 
• 6482-98-0 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid 

Relevant academic research and scientific papers

Butenolide derivative as well as preparation method and application thereof

The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.

Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2.

A series of analogues of butyrolactone I, a natural product isolated from Aspergillus terreus that selectively inhibits the CDK2 and CDK1 kinases and that has been found to exhibit an interesting antiproliferative activity, have been synthesized. Its anti

Novel 4,5-diaryl-3-hydroxy-2(5H)-furanones as anti-oxidants and anti-inflammatory agents

In order to study the effect of phenol moieties on biological activities of ascorbic acid derivatives, we synthesized 13 novel 4,5-diaryl-3-hydroxy-2(5H)-furanones 5a-m with various substitution patterns. Compound 5g bearing a 2,3-dihydroxy phenyl ring on

Syntheses and novel bioactivities of artificial leaf-opening substances of Lespedeza cuneata G. Don, designed for the bioorganic studies of nyctinasty

Potassium lespedezate (1) is the leaf-opening substance of a nyctinastic plant, Lespedeza cuneata G. Don. We have synthesized two sugar-derivatives of 1, potassium galactolespedezate (4) and mannolespedezate (6). Both 4 and 6 were quite effective for the leaf-opening of Cassia. mimosoides at 8 x 10-7 M, as strong as 1. However, 1 kept the leaf open only for a few days; on the other hand, 4 and 6 kept the leaf open after a week at that concentration. Additionally, remarkable difference was observed in the rate of enzymatic hydrolysis of natural and artificial leaf-opening sustance by using commercially available β-glucosidase. Therefore, 4 and 6 would not be hydrolized in the plant body, and are potentially useful molecular probes for the studies of the control of the nyctinastic leaf-movement by a biological clock.

Total synthesis of (+)-(2S,3R)-piscidic acid via catalytic asymmetric dihydroxylation of a trisubstituted olefin

(+)-(2S,3R)-Piscidic acid was efficiently synthesized with high optical purity (90% e.e.) via Sharpless catalytic asymmetric dihydroxylation of a trisubstituted olefin in only 6 steps from commercially available 4-hydroxyphenylpyruvic acid as the starting