80171-33-1

Basic information

• Product Name: NSC49419
• Synonyms: NSC49419;PhenylMethylene hydantoin [PMH];5-(4'-Hydroxybenzylidene)hydantoin;5-(4-Hydroxybenzylidene)hydantoin;5-(4-Hydroxyphenyl)methylenehydantoin
• CAS NO: 80171-33-1
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.184
• Mol File: 80171-33-1.mol
• Article Data: 22

Chemical Properties

• Melting Point: 316-318℃
• Appearance: /
• Density: 1.458g/cm³
• Refractive Index: 1.686
• CAS DataBase Reference: NSC49419(CAS DataBase Reference)
• NIST Chemistry Reference: NSC49419(80171-33-1)
• EPA Substance Registry System: NSC49419(80171-33-1)

Safety Data

• Hazardous Substances Data: 80171-33-1(Hazardous Substances Data)

Usage

General Description

NSC49419, also known as BRD-K81973277, is a small molecule compound with potential therapeutic applications. It is an inhibitor of the enzyme histone deacetylase 2 (HDAC2), which plays a role in regulating gene expression and chromatin structure. By inhibiting HDAC2, NSC49419 may exert anti-inflammatory and anti-cancer effects, making it a potential candidate for the treatment of diseases such as rheumatoid arthritis and certain types of cancer. Further research is needed to fully understand the therapeutic potential and mechanisms of action of NSC49419, but it holds promise as a novel target for drug development.

InChI:InChI=1/C10H8N2O3/c13-7-3-1-6(2-4-7)5-8-9(14)12-10(15)11-8/h1-5,13H,(H2,11,12,14,15)/b8-5-

Upstream product

• 461-72-3 2,4-imidazolidinedione 
• 123-08-0 4-hydroxy-benzaldehyde 
• 6318-40-7 (5Z)-5-(4-hydroxybenzylidene)-2-thioxoimidazolidin-4-one 
• 110-89-4 piperidine 

Downstream Products

• 156-39-8 4-hydroxyphenylpiruvic acid 
• 58942-04-4 5-(4-hydroxy-benzyl)-imidazolidine-2,4-dione 
• 154292-21-4 5-(4-(benzyloxy)benzylidene)imidazolidine-2,4-dione 
• 402609-20-5 5-(4-((2-chlorobenzyl)oxy)benzylidene)imidazolidine-2,4-dione 
• 56401-28-6 [2-hydroxyimino-3-(4-hydroxyphenyl)]propionic acid 
• 10589-28-3 2-hydroxy-3-(4-hydroxyphenyl)-2-propenoic acid 

Relevant articles and documents

Design, synthesis, biological evaluation and molecular dynamics simulation studies of imidazolidine-2,4-dione derivatives as novel PTP1B inhibitors

Protein tyrosine phosphatase 1B (PTP1B) is a member of the phosphotyrosine phosphatase family and plays an important role in the signal transduction of diabetes. Inhibition of PTP1B activity can increase insulin sensitivity and reduce blood sugar levels.

Furanone compound and preparation method and application thereof

The invention discloses a furanone compound and a preparation method and application thereof. P-hydroxybenzaldehyde is used as a raw material, condensed with hydantoin and then subjected to alkaline hydrolysis and esterification to obtain a p-hydroxyphenylpyruvate intermediate; p-hydroxy benzaldehyde and halogenated isopentene are subjected to alkylation, and then benzyl protection is performed toobtain a benzaldehyde derivative intermediate; a benzaldehyde derivative intermediate and a phenylpyruvate intermediate are subjected to aldol condensation and intramolecular esterification under thecatalysis of a condensing agent to synthesize novel furanone compounds BL5 and BL10. The furanone derivative has H1N1 virus inhibition activity, and can be used for preparing medicines for treating H1N1 virus infection.

New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof

PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.