88197-50-6

Basic information

• Product Name: (Z)-Cinepazide
• Synonyms: (Z)-Cinepazide;Cinepazide Impurity 2;Cinepazide Impurity C;Z-Cinepazide Oxalate;(Z)-1-(4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one;Cinepazide Impurity A
• CAS NO: 88197-50-6
• Molecular Formula: C22H31N3O5
• Molecular Weight: 417.5
• Mol File: 88197-50-6.mol

Chemical Properties

• Boiling Point: 637.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.200±0.06 g/cm3(Predicted)
• PKA: 5.22±0.10(Predicted)
• CAS DataBase Reference: (Z)-Cinepazide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-Cinepazide(88197-50-6)
• EPA Substance Registry System: (Z)-Cinepazide(88197-50-6)

Safety Data

• Hazardous Substances Data: 88197-50-6(Hazardous Substances Data)

Usage

Uses

Used in Cardiovascular Applications:
(Z)-Cinepazide is used as a vasodilator for improving blood circulation in the body. Its application reason is to manage conditions such as peripheral arterial disease, ischemic heart disease, and other cardiovascular disorders by widening blood vessels and enhancing blood flow.
Used in Neurological Applications:
(Z)-Cinepazide is used as a potential neuroprotective agent for the treatment of neurological disorders such as stroke and Alzheimer's disease. Its application reason is to provide protection to the neurons and potentially improve outcomes in these conditions due to its neuroprotective properties.

Upstream product

• 39890-45-4 1-[(pyrrolidine-1-carbonyl)methyl]piperazine 
• 10263-19-1 3',4',5'-trimethoxycinnamoyl chloride 
• 10263-19-1 (E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride 
• 24152-95-2 2-amino-1-(pyrrolidin-1-yl)ethan-1-one 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1878-29-1 ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate 
• 90892-09-4 bromoacetopyrrolidine 
• 88053-13-8 N-(3,4,5-trimethoxy cinnamoyl)-piperazine 

Relevant articles and documents

Preparation method of cinepazide maleate intermediate

The invention provides a preparation method of a cinepazide maleate intermediate, which comprises the following steps: reacting (E) 3, 4, 5trimethoxycinnamoyl chloride and diethanol amine used as initial raw materials under the action of alkali to generate an intermediate c (E) N, N-(2-hydroxyethyl)-3, 4, 5-trimethoxycinnamamide, chlorinating hydroxyl under the action of thionyl chloride to obtainan intermediate d (E) N, N-(2-chloroethyl)-3, 4, 5-trimethoxycinnamamide, and reacting with e alpha-aminoacetylpyrrolidine to generate cinepazide. The synthesis route has the advantages that (1) allthe raw materials are low in cost and easy to obtain on the market and (2) the process post-treatment steps are greatly simplified, the control is easy, the industrial production can be realized, andthe process cost is reduced.

Concise and efficient synthesis of cinepazide

An efficient synthesis of cinepazide has been carried out in four steps with an overall yield of 51%. The synthesis was started from a commercially available 3,4,5-tri-methoxy benzaldehyde. All the reactions were very clean and the isolation of products was also very easy.